Methacholine-induced bronchoconstriction and airway smooth muscle in the guinea pig

Journal of Applied Physiology

Volumn 80, Issue 2, 1996, Pages 437-444

  Opazo Saez, A ^a   Du, Tao ^a   Wang, N S ^a   Martin, J G ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

airway responsiveness; limited bronchoconstriction; morphometry

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; GUINEA PIG; LUNG RESISTANCE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE;

EID: 13344277369     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.80.2.437     Document Type: Article

References (37)

1. Antonissen, L. A., R. W. Mitchell, E. A. Kroeger, W. Kepron, K. S. Tse, and N. L. Stephens. Mechanical alterations of airway smooth muscle in a canine asthmatic model. J. Appl. Physiol. 46: 681-687, 1979.
2. Armour, C. L., N. M. Lazar, R. R. Schellenberg, S. M. Taylor, N. Chan, J. C. Hogg, and P. D. Paré. A comparison of in vivo and in vitro human airway reactivity to histamine. Am. Rev. Respir. Dis. 129: 907-910, 1984.
3. Bai, A., D. H. Eidelman, J. C. Hogg, A. L. James, R. K. Lambert, M. S. Ludwig, J. Martin, D. M. McDonald, W. A. Mitzner, M. Okazawa, R. J. Pack, P. D. Paré, R. R. Schellenberg, H. A. W. M. Tiddens, E. M. Wagner, and D. Yager. Proposed nomenclature for quantifying subdivisions of the bronchial wall. J. Appl. Physiol. 77: 1011-1014, 1995.
4. Bellofiore, S., D. H. Eidelman, P. T. Macklem, and J. G. Martin. Effects of elastase-induced emphysema on airway responsiveness to methacholine in rats. J. Appl. Physiol. 66: 506-612, 1989.
5. Brain, J. D., and P. A. Valberg. State of the art deposition of aerosol in the respiratory tract. Am. Rev. Respir. Dis. 120: 1325-1375, 1979.
6. Brown, R. H., C. J. Herold, C. A. Hirshman, L. A. Zerhouni, and W. Mitzner. In vivo measurements of airway reactivity using high-resolution computed tomography. Am. Rev. Respir. Dis. 144: 208-212, 1991.
7. Chitano, P., P. Maestrelli, C. E. Mapp, K. Rainey, and L. M. Fabbri. Nedocromil sodium and disodium cromoglycate inhibit human neutrophil chemotaxis in vitro (Abstract). Am. Rev. Respir. Dis. 139: A370, 1989.
8. Cockcroft, D. W., D. N. Killian, J. J. Mellon, and F. E. Hargreave. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin. Allergy 7: 235-243, 1977.
9. Dandurand, R. T., C. G. Wang, N. C. Phillips, and D. H. Eidelman. Responsiveness of individual airways to methacholine in adult rat lung explants. J. Appl. Physiol. 75: 364-372, 1993.
10. Ding, D. J., J. G. Martin, and P. T. Macklem. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal human subjects. J. Appl. Physiol. 62: 1324-1330, 1987.
11. Douglas, J. S., P. Ridgway, and C. Brink. Airway responses of the guinea pig in vivo and in vitro. J. Pharmacol. Exp. Ther. 202: 116-124, 1977.
12. Eidelman, D. H., M. Lei, and R. H. Ghezzo. Morphometry of methacholine-induced bronchoconstriction in the rat. J. Appl. Physiol. 75: 1702-1710, 1993.
13. Engel, L. A., L. Landau, L. Taussig, R. R. Martin, and G. Sybrecht. Influence of bronchomotor tone on regional ventilation distribution at residual volume. J. Appl. Physiol. 40: 411-416, 1976.
14. Horsfield, K. Morphometry of the airways. In: Handbook of Physiology. The Respiratory System. Mechanics of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. III, pt. 1, chapt. 7, p. 75-88.
15. Hulbert, W. C., T. McLean, B. Wiggs, P. D. Paré, and J. C. Hogg. Histamine dose-response curves in guinea pigs. J. Appl. Physiol. 58: 625-634, 1985.
16. James, A. L., J. C. Hogg, L. A. Dunn, and P. D. Paré. The use of the internal perimeter to compare airway size and to calculate smooth muscle shortening. Am. Rev. Respir. Dis. 138: 136-139, 1995.
17. Ludwig, M. S., I. Dreshaj, J. Solway, A. Munoz, and R. H. Ingram, Jr. Partitioning of pulmonary resistance during constriction in the dog: effects of volume history. J. Appl. Physiol. 62: 807-815, 1987.
18. 4. J. Appl. Physiol. 65: 1424-1429, 1988.
19. Macklem, P. T. Bronchial hyperresponsiveness. Chest 87: 158S-159S, 1985.
20. Marshall, R., and A. B. DuBois. The measurement of the viscous resistance of the lung tissues in normal man. Clin. Sci. Lond. 15: 161-170, 1956.
21. Martin, J. G., A. Opazo Saez, T. Du, R. Tepper, and D. H. Eidelman. In vivo airway reactivity: predictive value of morphological estimates of airway smooth muscle (Review). Can. J. Physiol. Pharmacol. 70: 597-601, 1992.
22. Moreno, R. H., J. C. Hogg, and P. D. Paré. Mechanics of airway narrowing. Am. Rev. Respir. Dis. 133: 1171-1180, 1986.
23. Nagase, T., T. Ito, M. Yanai, J. G. Martin, and M. S. Ludwig. Responsiveness of and interactions between airways and tissue in guinea pigs during induced constriction. J. Appl. Physiol. 74: 2848-2854, 1993.
24. Nagase, T., A. Moretto, and M. Ludwig. Airway and tissue behavior during induced constriction in rats: intravenous vs. aerosol administration. J. Appl. Physiol. 76: 830-838, 1994.
25. Rodriguez-Roisin, R., A. Ferrer, D. Navajas, A. G. Agusti, P. D. Wagner, and J. Roca. Ventilation-perfusion mismatch after methacholine challenge in patients with mild bronchial asthma (published erratum appears in Am. Rev. Respir. Dis. 144: 995, 1991). Am. Rev. Respir. Dis. 144: 88-94, 1991.
26. Romero, P. V., and M. S. Ludwig. Maximal methacholine-induced constriction in rabbit lung: interactions between airways and tissue? J. Appl. Physiol. 70: 1044-1050, 1991.
27. Ruffin, R. E., M. B. Dolovich, R. K. Wolff, and M. T. Newhouse. The effects of preferential deposition of histamine in the human airway. Am. Rev. Respir. Dis. 117: 485-492, 1978.
28. Sekizawa, K., M. Yanai, Y. Shimizu, H. Sasaki, and T. Takishima. Serial distribution of bronchoconstriction in normal subjects. Methacholine versus histamine. Am. Rev. Respir. Dis. 137: 1312-1316, 1988.
29. Sly, P. D., K. A. Brown, J. H. T. Bates, P. T. Macklem, J. Milic-Emili, and J. G. Martin. The effect of lung volume on interrupter resistances in cats challenged with methacholine. J. Appl. Physiol. 64: 360-366, 1988.
30. Smaldone, G. C., and M. S. Messina. Enhancement of particle deposition by flow-limiting segments in humans. J. Appl. Physiol. 59: 509-514, 1985.
31. Snapper, J. R., J. M. Drazen, S. H. Loring, W. Schneider, and R. H. Ingram, Jr. Distribution of pulmonary responsiveness to aerosol histamine in dogs. J. Appl. Physiol. 44: 738-742, 1978.
32. 2 test. Thorax 23: 628-633, 1968.
33. Sterk, P. J., E. E. Daniel, N. Zamel, and F. E. Hargreave. Limited maximal airway narrowing in nonasthmatic subjects. Role of neural control and prostaglandin release. Am. Rev. Respir. Dis. 132: 865-870, 1985.
34. Taylor, S. M., P. D. Paré, C. L. Armour, J. C. Hogg, and R. R. Schellenberg. Airway reactivity in chronic obstructive pulmonary disease. Failure of in vivo methacholine responsiveness to correlate with cholinergic, adrenergic, or nonadrenergic responses in vitro. Am. Rev. Respir. Dis. 132: 30-35, 1985.
35. Vincenc, K. S., J. L. Black, K. Yan, C. L. Armour, P. D. Donnelly, and A. J. Woolcock. Comparison of in vivo and in vitro responses to histamine in human airways. Am. Rev. Respir. Dis. 128: 875-879, 1983.
36. Vinegar, A., E. E. Sinnett, and D. E. Leith. Dynamic mechanisms determine functional residual capacity in mice, Mus musculus. J. Appl. Physiol. 46: 867-871, 1979.
37. Yager, D., J. P. Butler, J. Bastacky, E. Israel, G. Smith, and J. M. Drazen. Amplification of airway constriction due to liquid filling of airway interstices. J. Appl. Physiol. 66: 2873-2884, 1989.