Nuclear DNA content and pathology in radically treated pancreatic carcinoma: The prognostic significance of DNA ploidy, histology and nuclear grade

Cancer

Volumn 77, Issue 3, 1996, Pages 459-466

  Rugge, Massimo ^a   Sonego, Fulvia ^a   Sessa, Fausto ^b   Leandro, Gioacchino ^c   Capella, Carlo ^b   Sperti, Cosimo ^a   Pasquali, Claudio ^a   Di Mario, Francesco ^a   Pedrazzoli, Sergio ^a   Ninfo, Vito ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c Istituto Gastroenterologico   (Italy)

Author keywords

DNA ploidy; histology and DNA ploidy; nuclear grade and ploidy; pancreatic carcinoma; ploidy and prognosis

Indexed keywords

CELL NUCLEUS DNA;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER STAGING; CLINICAL FEATURE; DNA CONTENT; FEMALE; FLOW CYTOMETRY; HISTOLOGY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PANCREAS CARCINOMA; PANCREAS RESECTION; PLOIDY; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL RATE;

ADULT; AGED; CELL NUCLEUS; DNA, NEOPLASM; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PANCREATIC NEOPLASMS; PLOIDIES; PROGNOSIS; SURVIVAL RATE;

EID: 13344275853     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19960201)77:3<459::AID-CNCR6>3.0.CO;2-F     Document Type: Article

References (38)

1. Connoly MM, Dawson PJ, Michelassi F. Survival in 1001 patients with carcinoma of the pancreas. Ann Surg 1987;206:366-73.
2. Billesbolle P, Larsen LG, Burchart F, Baden H. Long-term survival after resection of ductal carcinoma in the body and tail of the pancreas. HPB Surg 1990;2:51-5.
3. Böttger T, Zech J. Relevant factors for prognosis of ductal pancreatic carcinoma. Acta Chir Scand 1990;156:781-8.
4. Weger AR, Falkmer UG, Schwab G, Glaser K, Kemmler G, Bodner E, et al. Nuclear DNA distribution pattern of the parenchymal cells in adeno-carcinomas of the pancreas and in chronic pancreatitis. Gastroenterology 1990;99:237-42.
5. Camerun JL, Crist DW. Factors influencing survival after pancreatico-duodenectomy for pancreatic cancer. Am J Surg 1991;161:120-6.
6. Bergenfeldt M, Hedberg M, Genell S. Pancreaticoduodenectomy: 13-years' experience. Eur J Surg 1992;158:117-21.
7. Bose KK, Allison DC, Hruban RH, Piantadosi S, Zahurak M, Dooley WC, et al. A comparison of flow cytometric and absorption cytometric DNA values as prognostic indicators for pancreatic carcinoma. Cancer 1993;71:691-700.
8. Sperti C, Bonadimani B, Pasquali C, Piccoli A, Cappellazzo F, Rugge M, et al. Ductal adenocarcinoma of the pancreas: clinicopathological features and survival. Tumori 1993;79:325-30.
9. Manabe T, Suzuki T, Tobe T. Factors influencing prognosis and indications for curative pancreatectomy for ductal adenocarcinoma of the head of the pancreas. Int J Pancreatol 1990;7:187-93.
10. Koss LG, Czerniak B, Herz F, Wersto RP. Flow cytometric measurements of DNA and other cell components on human tumors: a critical appraisal. Hum Pathol 1989;20:528-48.
11. Mellin W, Olf C, Bocker XV. DNA-Zytophotometrie am Magenkarzinom - Ein Vergleich zwischen der statischen Zytophotometrie an Schnitt-praparaten und Ausstrichpraparaten und der Flusszytophotometrie. Verh Dtsch Ges Pathol 1990;74:203-6.
12. Cope C, Rowe D, Delbridge L, Philips J, Friedlander M. Comparison of image analysts and flow cytometric determination of cellular DNA content. J Clin Pathol 1991;44:147-51.
13. Vielh P, Chassevent A. A tool for diagnosis and prognosis. In: P Vielh, editor. Flow cytometry. New York, Tokyo: Igaku-Shoin, 1991:69-108.
14. Rugge M, Sonego F, Panozzo M, Baffa R, Rubio J, Farinati F, et al. Pathology and ploidy in the prognosis of cancer with no extranodal metastasis. Cancer 1994;73:1127-33.
15. Eskelinen M, Lipponen P, Marin S, Haapasalo H, Makinen K, Puittinen J, et al. DNA ploidy, S-phase fraction, and G2 fraction as prognostic determinants in human pancreatic cancer. Scand J Gastroenterol 1992;27:39-43.
16. Böttger TC, Storkel S, Wellek S, Stockle M, Junginger T. Factors influencing survival after resection of pancreatic cancer. Cancer 1994;73:63-73.
17. Baisch H, Kloppel G, Reinke B. DNA ploidy and cell-cycle analysis in pancreatic and ampullary carcinoma: flow cytometric study of formalin-fixed paraffin-embedded tissue. Virchows Arch A Pathol Anat Histopathol 1990;417:145-50.
18. Kloppel G, Lingenthal G, Von Bulow M, Kern HF. Histological and fine structural features of pancreatic ductal adenocarcinoma in relation to growth and prognosis: studies of xenografted tumors and clinico-histopathological correlation in a series of 75 cases. Histopathology 1985;9:841-56.
19. Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphological parameters in renal cell carcinoma. Am J Surg Pathol 1982;6:655-60.
20. American Joint Committee on Cancer. Manual for staging of cancer. 3rd edition. Philadelphia: Lippincott Company, 1988.
21. Dressier LG, Bartow SA. DNA flow cytometry in solid tumors: practical aspects and clinical applications. Semin Diagn Pathol 1989;6:55-82.
22. Wersto RP, Liblit RL, Koss LG. Flow cytometric DNA analysis of human solid tumors: a review of the interpretation of DNA histograms. Hum Pathol 1991;22:1085-98.
23. Baish H, Gohdeh W, Linden W. Analysis of PCP-data to determine the fraction of cells in the various phases of the cell cycle. Radiat Environ Biophys 1975;12:31-9.
24. Emdin SO, Stenling R, Roos G. Prognostic value of DNA content in colorectal carcinoma. Cancer 1987;60:82-8.
25. Heimann TM, Miller F, Martinelli G, Mester J, Kurtz RJ, Szporn A, et al. Significance of DNA content abnormalities in small rectal cancers. Am J Surg 1990;159:199-203.
26. Weger RA, Mikuz G, Askensten U, Auer GU, Schwab G, Glaser KS. Methodological aspects of DNA image cytometry in formalin-fixed paraffin-embedded material from pancreatic adenocarcinoma. Pathol Res Pract 1989;185:752-4.
27. Alanen KA, Joensuu H, Klemi PJ, Nevalainen TJ. Clinical significance of nuclear DNA content in pancreatic carcinoma. J Pathol 1990;160:313-20.
28. Allison DC, Bose KK, Hruban RH, Pintadosi S, Dooley WC, Boitnott JK, et al. Pancreatic cancer cell DNA content correlates with long-term survival after pancreatectomy. Ann Surg 1991;214:649-56.
29. Eskelinen M, Lipponen P, Collan Y, Marin S, Alhava E, Nordling S. Relationship between DNA ploidy and survival in patients with exocrine pancreatic cancer. Pancreas 1991;6:90-5.
30. Hyöty M, Visakorpi T, Kallioniemi OP, Mattila J, Laippala P, Nordback I. Prognostic value of analysis of DNA in pancreatic adenocarcinoma by flow cytometry. Eur J Surg 1991;157:595-600.
31. Herrera MF, van Heerden JA, Katzmann JA, Weiland LH, Nagomey DM, Ilstrup D. Evaluation of DNA nuclear pattern as a prognostic determinant in resected pancreatic ductal adenocarcinoma. Ann Surg 1991;215:120-4.
32. Yoshimura T, Manabe T, Imamura T, Imanishi K, Ohshio G, Yamabe H, et al. Flow cytometric analysis of nuclear DNA content of duct cell carcinoma of the pancreas. Cancer 1992;70:1069-74.
33. Porschen R, Remy U, Bevers G, Schauseil S, Henghels KJ, Borchard F. Prognostic significance of DNA ploidy in adenocarcinomas of the pancreas. Cancer 1993;71:3846-50.
34. Alanen KA, Joensuu H, Klemi PJ. Letter to the editor. Virchows Arch A Pathol Anat Histopathol 1991;419:255-6.
35. Baba H, Korenaga D, Okamura T, Saito A, Watanabe A, Sugimaki K. Prognostic significance of DNA content with special reference to age in gastric cancer. Cancer 1989;63:1768-72.
36. Lipponen P, Eskelinen M, Nordling S. Relationship between DNA flow cytometric data, nuclear morphometric variables and volume corrected mitotic index in transitional cell bladder cancer. Eur Urol 1991;19:327-31.
37. Rothman KJ. Modern epidemiology. Boston: Little, Brown and Co., 1986:312-22.
38. Alanen KA, Joensuu H. Long-term survival after pancreatic adenocarcinoma - often a misdiagnosis? Br J Cancer 1993;68:1004-5.