Lung hypoplasia and surfactant system immaturity induced in the fetal rat by prenatal exposure to nitrofen

Neonatology

Volumn 69, Issue 2, 1996, Pages 94-100

  Alfonso, Luisa F ^a   Arnaiz, Arantzazu ^a   Alvarez, Francisco J ^a   Qi, Baoquan ^b   Diez Pardo, Juan A ^b   Vallis I Soler, Adolf ^a   Tovar, Juan A ^b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Congenital diaphragmatic hernia; Lung immaturity; Nitrofen; Pulmonary hypoplasia; Surfactant

Indexed keywords

CELL DNA; LUNG SURFACTANT; NITROFEN; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CONGENITAL DIAPHRAGM HERNIA; CONTROLLED STUDY; FETUS; FETUS LUNG MATURITY; LUNG HYPOPLASIA; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT;

ANIMALS; FEMALE; HERNIA, DIAPHRAGMATIC; LUNG; MALE; PHENYL ETHERS; PHOSPHATIDYLCHOLINES; PHOSPHOLIPIDS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PULMONARY SURFACTANTS; RATS; RATS, WISTAR;

EID: 13344275851     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000244283     Document Type: Article

References (32)

1. Butler N, Claireaux AE: Congenital diaphragmatic hernia as a cause of perinatal mortality. Lancet 1962:i: 659-663.
2. George DK, Cooney TP, Chiu BK, Thurlbcck WM: Hypoplasia and immaturity of the terminal lung unit (acinus) in congenital diaphragmatic hernia. Am Rev Respir Dis 1987: 136:947-950.
3. Pringle KC: Lung development in congenital diaphragmatic hernia: in Puri P (ed): Congenital Diaphragmatic Hernia. Basel. Karger. 1989. pp 28-53.
4. Pringle KC, Turner JW, Schofield JC, Soper RT: Creation and repair of diaphragmatic hernia in the fetal lamb: Lung development and morphology. J Pediatr Surg 1984; 19: 131-140.
5. Hashimoto EG. Pringle KC. Soper RT. Brown CK: The creation and repair of diaphragmatic hernia in fetal lambs: Morphology of the type 11 alveolar cell. J Pediatr Surg 1985:20: 354-356.
6. Alfonso LF, Vilanova J, Aldazabal P, Lopez de Torre B, Tovar JA: Lung growth and maturation in the rat model of experimentally induced congenital diaphragmatic hernia. Eur J Pediatr Surg 1993:3:6-11.
7. Glick PL. Stannard VA. Leach CL. Rossman J. Hosada Y. Morin FC. Cooney DR. Allen JE. Holm B: Pathophysiology of congenital diaphragmatic hernia. II. The fetal lamb C'DH model is surfactant deficient. J Pediatr Surg 1992.27:382-388.
8. Sucn HC. Catlin EA. Ryan DP. Wain JC. Donahoc PK: Biochemical immaturity of lungs in congenital diaphragmatic hernia. J Pediatr Surg 1993:28:471-477.
9. Suen HC. Losty P. Donahoc PK. Schnitzcr JJ: Combined antenatal thyrotropin-releasing hormone and low-dosc glucocorticoid therapy improves the pulmonary' biochemical immaturity in congenital diaphragmatic hernia. J Pediatr Surg 1994; 29:359-363.
10. Wilcox DT. Glick PL. Karamanoukiati HL. Holm BA: Pathophysiology of congenital diaphragmatic hernia. IX. Correlation of surfactant maturation with fetal cortisol and triiodothyronine concentration. J Pediatr Surg 1994:29:825-827.
11. Bos AP. Tibboel D. Hazebroek FWJ. Molenaar JC. Lachman B. Gommcrs D: Surfactant replacement therapy in high-risk congenital diaphragmatic hernia. Lancet 1991; 338:1279.
12. Glick PL. Leach CL. Besncr GE. Egan EA. Morin FC. Malanowska-Kantoch A. Robinson LK. Brody A. Lele AS. McDonnell M. Holm B, Rodgers BT, Msall ME, Courcy NG. Karp MP. Allen JE. Jewett TC. Cooney DR: Pathophysiology of congenital diaphragmatic hernia. III. Exogenous surfactant therapy for the high-risk neonate with CDII. J Pediatr Surg 199:27:866-869.
13. Stone LC. Manson JM: Effects of the 2.4-dichlorophenyl-p-nitrofenyl ether (nitrofcn) on fetal lung development in rats. Toxicology 1981:20: 195-207.
14. Iritani I: Experimental study on cm-bryogencsis of congenital diaphragmatic hernia. Anal Embryol 1984; 169:133-139.
15. Kluth D, Tenbrinck R, Von Ekcsparre M, Kangah R, Reich P, Brandsma A, Tibboel D, Lambrecht W: The natural history of CDH and pulmonary hypoplasia in the embryo. J Pediatr Surg 1993:28:456-463.
16. Kluth D, Kangah R, Reich P, Tenbrinck R, Tibboel D, Lambrecht W: Nitrofcn-induced diaphragmatic hernias in rats: An animal model. J PediatrSurg 1990:25:850-854.
17. Labarca C. Paigen K: A simple, rapid and sensitive DNA assay procedure. Anal Biochem 1980:102:344-352.
18. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protcin-dye binding. Anal Biochem 1976:72: 248-254.
19. Folch J. Lees M. Stanley GHS: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Client 1957:226: 497-509.
20. Stewart JCM: Colorimetric determination of phospholipids with ammonium ferrothiocyanatc. Anal Biochem 1980:104:10-14.
21. Manson RJ, Nellenbogen J, Clements JA: Isolation of disaturated phosphatidylcholine with osmium tetroxide. J Lipid Res 1976; 17:281-284.
22. Berk C. Grundy M: 'High risk' leci-thin/sphyngomyelin ratios associated with neonatal diaphragmatic hernia. Case reports. Br J Obstet Gynaecol 1982:89:250-251.
23. Hisanaga S. Shimokawa H. Kashi-wabara Y. Maesato S. Nakano H: Unexpectedly low lecithin/sphingomyelin ratio associated with fetal diaphragmatic hernia. Am J Obstet Gynecol 1984:149:905-906.
24. Sullivan KM, Hagwood S, Flake AW, Harrison MR, Adzick NS: Am-niotic fluid phospholipid analysis in the fetus with congenital diaphragmatic hernia. Eur J Pcdiatr Surg 1994:29:1020-1024.
25. Blackburn WR. Logsdon P. Alexander JA: Congenital diaphragmatic hernia: Studies of lung composition and structure. Am Rev Respir Dis 1977:115:275.
26. Wigglesworth JS, Desai R, Guerrini P: Fetal lung hypoplasia: Biochemical and structural variations and their possible significance. Arch Dis Child 1981:56:606-615.
27. Moya FR. Montes HF. Thomas VL. Mouzinho AM. Smith JF. Rosenfeld CR: Surfactant protein A and saturated phosphatidylcholine in respiratory distress syndrome. Am J Respir Care Med 1994:150:1672-1677.
28. Bos AP. Tcnbrinck R. Tibboel D. Molenaar JC. Lachmann B: Artificial ventilation in newborn rats with experimentally induced congenital diaphragmatic hernia. Pcdiatr Res 1990:27:296A.
29. Mysore M. Jaramillo M. Arevalo M. Thomas V. Margraf L. Moya F: Ul-trastructural analysis and immuno-cytochemical staining for surfactant protein-A (SP-A) of rat lungs with nitrofcn-induced congenital diaphragmatic hernia (CDH). Pediatr Res 1994:35:346A.
30. Manson JM: Mechanism of nitrofcn tcratogcnesis. Environ Health Per-spect 1986:70:137-147.
31. Stone LC. Manson JM: Effects of the herbicide 2.4-dichlorophenyl-p-nitrophenyl ether (nitrofcn) on fetal lung development in rats. Toxicology 1981:20:195-207.
32. Zimmcrmann LJ, Ijssclstijn H, Scheffers EC, Sayer PJJ, Batcnburg JJ, Tibboel D: Decreased activity of phosphocholinc cytidylyltransferase in type II pneumocytes from rats with congenital diaphragmatic hernia (CDH). Pediatr Res 1994:35: 359A.