The synthesis of β-benzyl l- A spartate and γ-benzyl l-glutamate by enzyme-catalyzed hydrolysis

Synthesis (Germany)

Volumn 1987, Issue 6, 1987, Pages 581-582

  Chen, Shui Tein ^a   Wang, Kung Tsung ^a  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 13344269574     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-1987-28014     Document Type: Article

References (11)

1. Zervas, L., Hamaladis, C. J Am. Chem. Soc. 1965. 87, 99.
2. Benoiton, L. Can. J. Chem. 1962, 40. 570.
3. Katsoyannis, P.G., Schwartz, G.P. Method Enzymol. 1977, 47, 528.
4. Hayakawa, I., Harada, K., Fox, S.W. Bull. Chem. Soc. Jpn. 1966, 39, 391.
5. Estrin, N.F., Vajda, T., Detur, D.F. Biochem. 1971. 13, 25.
6. Prestidge, R.L., Harding, D.R.K., Batt ereley, J.F., Hancock, W.S. J. Org. Chem. 1975, 40, 3287.
7. Ledger, R., Stewart, F.H.C. Ausl. J. Chem. 1965, 18. 1477.
8. Van Heeswijk, W.A.R., Eenink, M.J.D., Feijein, J. Synthesis 1982, 744.
9. Available from NOVO Industri A/S as a clean brown liquid. The en/yme Alcalase from Bacillus lieheriiforms is an endoproteinase of the serine type, the major component of which is subtilisin A (Subtilisin C-arlsberg). According to NOVO, one Anson Unit (AU) is the amount of enzyme which under standard conditions digests hemoglobin at an initial rale liberating per mill an amount of TC\ soluble product that gives the same color with phenol reager.t as one meq ol'Tyr (I Au 1000U, 1 U 1 mol l.-Tyr-OCH, hydroly-/ed per min). Thus Alcalase 2.5 L contains 2.5 AU/g.
10. Chen, S.T., Wang, K.T. Chem. Commun. in press.
11. Gunther, K., Schickedan, Z., Martens, J. Natimvissensehaften 1985, 72, 149.