Oleic acid inhibits cholesteryl esterase and cholesterol utilization for testosterone synthesis in mouse Leydig cells

Metabolism: Clinical and Experimental

Volumn 45, Issue 3, 1996, Pages 293-299

  Meikle, A Wayne ^a   Cardoso De Sousa, Jose C ^a   Hanzalova, Jitka ^a   Murray, Darrell K ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ESTERASE; LUTEINIZING HORMONE; OLEIC ACID; TESTOSTERONE;

ANIMAL TISSUE; ARTICLE; CHOLESTEROL METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; LEYDIG CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TESTOSTERONE SYNTHESIS;

EID: 13344261387     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90281-4     Document Type: Article

References (38)

1. Dufau ML: Endocrine regulation and communicating functions of the Leydig cell. Annu Rev Physiol 50:483-508, 1988
2. Saez J: Leydig cells: Endocrine, paracrine, and autocrine regulation. Endocr Rev 15:574-626, 1994
3. Hall PF: Testicular steroid synthesis: Organization and regulation, in Knobil E, Neill J (eds): The Physiology of Reproduction. New York, NY, Raven, 1988, pp 975-998
4. Freeman DA: Cyclic AMP mediated modification of cholesterol traffic in Leydig tumor cells. J Biol Chem 262:13061-13068, 1987
5. Hou AW, Collins DC, Schleicher RL: Sources of cholesterol for testosterone biosynthesis in murine Leydig cells. Endocrinology 127:2047-2055, 1990
6. Meikle AW, Benson SJ, Liu X, et al: Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. Am J Physiol 257:E937-E942, 1989
7. Meikle AW, Liu X, Stringham JD: Extracellular calcium and luteinizing hormone effects on cholesterol utilization for testosterone production in mouse Leydig cells. J Androl 12:148-151, 1991
8. Goodfriend TL, Ball DL, Elliott ME, et al: Fatty acids are potential endogenous regulators of aldosterone synthesis. Endocrinology 128:2511-2519, 1991
9. Meikle AW, Stringham JD, Bishop DT, et al: Quantitating genetic and nongenetic factors influencing androgen production and clearance in men. J Clin Endocrinol Metab 67:104-109, 1988
10. Meikle AW, Bishop DT, Stringham JD, et al: Relationship between body mass index, cigarette smoking and plasma sex-steroids in normal male twins. Genet Epidemiol 6:399-412, 1989
11. Meikle AW, Stringham JD, Woodward MG, et al: Effects of a fat-containing meal on sex hormones in men. Metabolism 39:943-946, 1990
12. Hanis T, Zidek V, Sachova J, et al: Effects of dietary trans-fatty acids on reproductive performance of Wistar rats. Br J Nutr 61:519-529, 1989
13. Hulsmann WC: Abnormal stress reactions after feeding diets rich in (very) long-chain fatty acids: High levels of corticosterone and testosterone. Mol Cell Endocrinol 12:1-8, 1978
14. Hamalainen EK, Adlercreutz H, Puska P, et al: Decrease of serum total and free testosterone during a low-fat high-fibre diet. J Steroid Biochem 18:369-370, 1983
15. Rojdmark S: Influence of short-term fasting on the pituitarytesticular axis in normal men. Horm Res 25:140-146, 1987
16. Herbert DC: Testicular testosterone concentrations in protein-calorie malnourished rats. Arch Androl 14:45-49, 1985
17. Anderson KE, Rosner W, Khan MS, et al: Diet-hormone interactions: Protein/carbohydrate ratio alters reciprocally the plasma levels of testosterone and cortisol and their respective binding globulins in man. Life Sci 40:1761-1768, 1987
18. Longcope C, Yosha S, Young RA, et al: The effects of low protein diet and testosterone on sex hormone-binding globulin capacity in male rabbits. Metabolism 36:703-707, 1987
19. Sebokva E, Garg ML, Clandinin MY: Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. Am J Physiol 254:E708-E712, 1988
20. Reaven GM, Chen YI: Role of abnormal free fatty acid metabolism in the development of non-insulin-dependent diabetes mellitus. Am J Med 85:106-112, 1988
21. Murray DK, Nelson DH: Dexamethasone inhibition of cholesterol-stimulated glucose transport in 3T3-L1 cells. Biochim Biophys Acta 898:308-312, 1987
22. Nagy L, Freeman DA: Effect of cholesterol transport inhibitors on steroidogenesis and plasma membrane cholesterol transport in MA-10 Leydig tumor cells. Endocrinology 126:2267-2276, 1990
23. Levy H, Deane HW, Rubin BL: Visualization of steroid-3B-ol-dehydrogenase activity in tissues of intact and hypophysectomized rats. Endocrinology 65:932-943, 1959
24. Lange Y, Steck TL: Cholesterol-rich intracellular membranes: A precursor to the plasma membrane. J Biol Chem 260:15592-15597, 1985
25. Goldstein JL, Dana SE, Brown MS: Esterification of low density lipoprotein cholesterol in human flbroblasts and its absence in homozygous familial hypercholesterolemia. Proc Natl Acad Sci USA 71:4288-4292, 1974
26. Ascoli M: Effects of hypocholesterolemia and chronic hormonal stimulation on sterol and steroid metabolism in a Leydig cell tumor. J Lipid Res 22:1247-1253, 1981
27. Popplewell PY, Azhar S: Effects of aging on cholesterol content and cholesterol-mobilizing enzymes in the rat adrenal gland. Endocrinology 121:64-73, 1987
28. Liao C, Reaven E, Azhar S: Age-related decline in the steroidogenic capacity of isolated rat Leydig cells: A defect in cholesterol mobilization and processing. J Steroid Biochem 46:39-47, 1993
29. Anderson JM, Dietschy JM: Relative importance of high and low density lipoproteins in the regulation of cholesterol synthesis in the adrenal gland, ovary, and testis of the rat. J Biol Chem 253:9024-9032, 1978
30. Freeman DA, Ascoli M: Studies on the source of cholesterol used for steroid biosynthesis in cultured Leydig cells. J Biol Chem 257:14231-14238, 1982
31. Behahmed M, Reventos J, Saez JM: Steroidogenesis of cultured purified pig Leydig cells: Effects of lipoproteins and human gonadotropin. Endocrinology 112:1952-1957, 1983
32. Quinn PG, Dombrausky LJ, Chen Y, et al: Serum lipoproteins increase testosterone production in hCG-desensitized Leydig cells. Endocrinology 109:1790-1792, 1981
33. Schumacher M, Schwarz M, Leidenberger L: Desensitization of mouse Leydig cell in vivo: Evidence for the depletion of cellular cholesterol. Biol Reprod 33:335-345, 1985
34. Iguchi T, Takasugi N, Nishimura N, et al: Correlation between mammary tumors and blood glucose, serum insulin, and free fatty acids in mice. Cancer Res 49:821-825, 1989
35. Lillioja S, Foley J, Bogardus D, et al: Free fatty acid metabolism and obesity in man: In vivo and in vitro comparisons. Metabolism 35:505-515, 1986
36. Avallet O, Vigier M, Chatelain PG, et al: Regulation by growth factors of Leydig cell differentiated functions. J Steroid Biochem Mol Biol 40:453-464, 1991
37. Gocze PM, Freeman DA: A cholesteryl ester hydrolase inhibitor blocks cholesterol translocation into the mitochondria of MA-10 Leydig tumor cells. Endocrinology 131:2972-2978, 1992
38. Daumerie CA, Woolett LA, Dietschy JM: Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools. Proc Natl Acad Sci USA 89:10797-10801, 1992