Phase I/II study with a weekly 24-hour infusion of 5-fluorouracil plus high-dose folinic acid (HD-FU/FA) in intensively pretreated patients with metastatic breast cancer

Annals of Oncology

Volumn 7, Issue 1, 1996, Pages 55-58

  Wilke, H ^a   Klaassen, U ^a   Achterrath, W ^a   Losch, M ^a   Vanhoefer, U ^a   Hayungs, J ^a   Harstrick, A ^a   Stahl, M ^a   Eberhardt, W ^a   Becher, R ^a   Seeber, S ^a  

^a UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

Author keywords

Folinic acid 5 fluorouracil; Phase I II trial; Pretreated breast cancer

Indexed keywords

ANTHRACYCLINE ANTIBIOTIC AGENT; FLUOROURACIL; FOLINIC ACID;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BREAST CANCER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL;

EID: 13244300698     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.annonc.a010478     Document Type: Article

References (19)

1. Henderson IC. Chemotherapy for advanced disease. In Harris JR, Hellman S, Henderson IC. Breast Diseases. Philadelphia PA: Lippincott 1987; 428-79.
2. Rowinsky EK, Onetto N, Canetta RM. Taxol: The first of the taxanes, an important new class of antitumor agents. Semin Oncol 1992; 19: 646-62.
3. Swain SM, Lippman ME, Egan EF et al. Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer. J Clin Oncol 1989; 7 (7): 890-9.
4. Doroshow JH, Leong L, Margolin K et al. Refractory metastatic breast cancer: Salvage therapy with fluorouracil and high-dose continuous-infusion leucovorin calcium. J Clin Oncol 1989; 7: 439-44.
5. Marini G, Simonchine E, Zaniboni A et al. 5-Fluorouracil and high-dose folinic acid as salvage treatment of advanced breast cancer: An update. Oncology 1987; 44: 336-40.
6. Fine S, Erlichman C, Kaizer L et al. Phase II trial of 5-FU and folinic acid as first-line treatment for metastatic breast cancer. Proc Am Soc Clin oncol 1988; 7: 41.
7. Loprinzi CL. 5-Fluorouracil with leucovorin in breast cancer. Cancer 1989; 63: 1045-7.
8. Hansen R, Quebbeman E, Beatty P. Continuous 5-fluorouracil infusion in refractory carcinoma of the breast. Breast Cancer Res Treat 1987; 10: 145-9.
9. Jabboury K, Holmes F, Teriault R et al. Fluorouracil rechallenge by protracted continuous infusion in refractory breast cancer. Proc Am Soc Clin oncol 1988; 7: 39.
10. Huan S, Singhakowinta A, Samal B et al. Efficacy of continuous infusion of low-dose 5-FU in previously treated metastatic breast cancer. Proc Am Soc Clin Oncol 1988; 7: 37.
11. Houghton JA, Schmidt C, Houghton P et al. The effect of derivatives of folinic acid on the fluorodesoxyuridylate-thymidylate synthase covalent complex in human colon xenografts. Eur J Cancer Clin Oncol 1982; 18: 347-54.
12. Yin MB, Zakrzewski SF, Hakala MT et al. Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil. Mol Pharmacol 1983; 23: 190-7.
13. Evans RM, Laskin JD, Hakala MT et al. Effects of excess folates and desoxynosine on the activity and site of action of 5-fluorouracil. Cancer Res 1981; 41: 3288-95.
14. Petrelli N, Herrera L, Rustum YM et al. A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 1987; 5: 1559-65.
15. Machover D, Goldschmidt E, Chollet P et al. Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil and high-dose folinic acid. J Clin Oncol 1986: 4: 685-96.
16. Doroshow TH, Bertrand M, Multhauf P et al. Prospective randomized trial comparing 5-FU versus 5-FU and high-dose folinic acid for treatment of advanced colorectal cancer. Proc Am Soc Clin Oncol 1987; 6: 96.
17. Erlichman C, Fine S, Wong A et al. A comparison of 5-fluorouracil and folinic acid versus 5-FU in metastatic colorectal carcinoma. Proc Am Soc Clin Oncol 1986; 5: 82.
18. Köhne-Wömpner CH, Schmoll HJ, Harstrick, Rustum YM. Chemotherapeutic strategies in metastatic colorectal cancer: An overview of current clinical trials. Semin Oncol 1992; 19: 105-25.
19. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457-81.