Superantigen hypothesis for the early development of chronic hyperplastic sinusitis with massive nasal polyposis

Current Opinion in Otolaryngology and Head and Neck Surgery

Volumn 13, Issue 1, 2005, Pages 39-44

  Bernstein, Joel M ^a,b,c,e   Kansal, Rita ^d  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c CHILDREN S HOSPITAL OF BUFFALO   (United States)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^e NONE   (United States)

Author keywords

Cytokines; Enterotoxin; Eosinophil; Staphylococcus aureus; Superantigen; Variable region of the T cell receptor

Indexed keywords

ANTIBIOTIC AGENT; EXOTOXIN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; MUCIN; STAPHYLOCOCCUS ENTEROTOXIN; STAPHYLOCOCCUS ENTEROTOXIN A; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR; TOXIC SHOCK SYNDROME TOXIN 1; VASCULAR CELL ADHESION MOLECULE 1;

ALLERGY; ANTIBIOTIC THERAPY; ANTIGEN EXPRESSION; BACTERIAL COLONIZATION; BACTERIAL INFECTION; BACTERIUM ISOLATE; CELL SURVIVAL; CHRONIC HYPERPLASTIC SINUSITIS; CLINICAL ARTICLE; CYTOKINE PRODUCTION; EOSINOPHIL; HUMAN; IMMUNOBIOLOGY; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE CLONE; MUCOSA INFLAMMATION; MYCOSIS; NONHUMAN; NOSE MUCOSA; NOSE MUCUS; NOSE POLYP; PATHOPHYSIOLOGY; POLLUTION; PRIORITY JOURNAL; REVIEW; SINUSITIS; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; TOXIN SYNTHESIS; UPREGULATION; VIRUS INFECTION;

BACTERIAL TOXINS; CHRONIC DISEASE; ENTEROTOXINS; EOSINOPHILIA; HUMANS; HYPERPLASIA; LYMPHOCYTES; MUCUS; NASAL MUCOSA; NASAL POLYPS; SINUSITIS; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS;

EID: 13244298249     PISSN: 10689508     EISSN: None     Source Type: Journal    
DOI: 10.1097/00020840-200502000-00010     Document Type: Review

References (13)

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12. McKay DM, Singh PK: Superantigen activation of immune cells evokes epithelial (T84) transport and barrier abnormalities via IFN-γ and TNF-α: inhibition of increased permeability, but not diminished secretory responses by TGF-β2. J Immunol 1997; 159:2382-2390. The conclusion of this study suggests that superantigens can elicit epithelial irregularities characteristic of enteric inflammation and that IFN-γ and TNF-α are key mediators in this co-culture model of epithelial dysfunction. Additionally, the authors highlight TGF-β2 in playing a role in preventing prolonged increases in epithelial permeability.
13. Schubert MS: A superantigen hypothesis for the pathogenesis of chronic hypertrophic rhinitis, allergic fungal sinusitis, and related disorders. Ann Allergy Asthma Immunol 2001; 87:181-188. The pathogenesis of all the disorders discussed such as chronic hypertrophic rhinosinusitis, allergic fungal sinusitis, and other eosinophilic-lymphocytic disorders can be unified through the superantigen hypothesis proposed. Multiple lines of evidence support this hypothesis, how we view these common conditions will change, and new research into pathogenesis and treatment will occur if this proves to be true.