Transcriptional regulation of pituitary gland development: Binary choices for cell differentiation

Current Opinion in Endocrinology and Diabetes

Volumn 11, Issue 1, 2004, Pages 13-17

  Pulichino, Anne Marie ^a   Vallette Kasic, Sophie ^a   Drouin, Jacques ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Hormone deficiency; Organogenesis; Pituitary differentiation; Transcription factor

Indexed keywords

HOMEODOMAIN PROTEIN; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR PITX1; TRANSCRIPTION FACTOR PITX2; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; GONADOTROPIN SECRETING CELL; HUMAN; HYPOPHYSIS; HYPOPHYSIS DISEASE; NONHUMAN; ORGANOGENESIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVIEW; TRANSCRIPTION REGULATION;

EID: 13244296770     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-200402000-00005     Document Type: Review

References (44)

1. Burrows HL, Douglas KR, Seasholtz AF, et al.: Genealogy of the Anterior Pituitary Gland: Tracing a Family Tree. Trends Endocrinol.Metab. 1999, 10:343-352.
2. Dattani MT, Robinson IC: The molecular basis for developmental disorders of the pituitary gland in man. Clin Genet 2000, 57:337-346.
3. Scully KM, Rosenfeld MG: Pituitary development: regulatory codes in mammalian organogenesis. Science 2002, 295:2231-2235.
4. Kimura S, Hara Y, Pineau T, et al.: The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev 1996, 10:60-69.
5. Hermesz E, Williams-Simons L, Mahon KA: A novel inducible element, activated by contact with Rathke's pouch, is present in the regulatory region of the Rpx/Hesx1 homeobox gene. Dev Biol 2003, 260:68-78. An elegant study using a transgenic reporter to show in tissue reconstitution experiments that isolated Rathke's pouches can induce gene expression in adjoining neuroepithelium.
6. Lamonerie T, Tremblay JJ, Lanctôt C, et al.: PTX1, a bicoid-related homeobox transcription factor involved in transcription of pro-opiomelanocortin (POMC) gene. Genes Dev 1996, 10:1284-1295.
7. Lin CR, Kioussi C, O'Connell S, et al.: Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature 1999, 401:279-282.
8. Gage PJ, Suh HY, Camper SA: Dosage requirement of Pitx2 for development of multiple organs. Development 1999, 126:4643-4651.
9. Suh H, Gage PJ, Drouin J, et al.: Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification. Development 2002, 129:329-337.
10. Lanctôt C, Moreau A, Chamberland M, et al.: Hindlimb patterning and mandible development require the Ptx1 gene. Development 1999, 126:1805-1810.
11. Harvey RP: Links in the left/right axial pathway. Cell 1998, 94:273-276.
12. Sheng HZ, Zhadanov AB, Mosinger B, et al.: Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science 1996, 272:1004-1007.
13. Sheng HZ, Moriyama K, Yamashita T, et al.: Multistep control of pituitary organogenesis. Science 1997, 278:1809-1812.
14. Tremblay JJ, Lanctôt C, Drouin J: The pan-pituitary activator of transcription, Ptx-1 (pituitary homeobox1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the Lim-homeodomain gene Lim3/Lhx3. Mol Endocrinol 1998, 12:428-441.
15. Netchine I, Sobrier ML, Krude H, et al.: Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency. Nat Genet 2000, 25:182-186.
16. Raetzman LT, Ward R, Camper SA: Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. Development 2002, 129:4229-4239. The authors have used single and double knockout mice to differentiate the respective roles of Lhx4 and Prop1 in early pituitary development. Lhx4 has a role in cell proliferation and control of apoptosis, whereas Prop1 was involved in dorsal-ventral patterning and possibly commitment of the dorsal cell lineages.
17. Ericson J, Norlin S, Jessell TM, et al.: Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development 1998, 125:1005-1015.
18. Treier M, Gleiberman AS, O'Connell SM, et al.: Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev 1998, 12:1691-1704.
19. Treier M, O'Connell S, Gleiberman A, et al.: Hedgehog signaling is required for pituitary gland development. Development 2001, 128:377-386.
20. Herzog W, Zeng X, Lele Z, et al.: Adenohypophysis formation in the zebrafish and its dependence on sonic hedgehog. Dev Biol 2003, 254:36-49. This is the first paper to report the zebrafish sequence of many pituitary hormones and to document their pattern of expression in the zebrafish pituitary.
21. Sbrogna JL, Barresi MJ, Karlstrom RO: Multiple roles for Hedgehog signaling in zebrafish pituitary development. Dev Biol 2003, 254:19-35. The pattern of gene expression for many factors previously implicated in early pituitary organogenesis in other species has been investigated in zebrafish, and their expression has been studied after manipulation of the Shh system.
22. Sornson MW, Wu W, Dasen JS, et al.: Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature 1996, 384:327-333.
23. Cohen LE, Radovick S: Molecular basis of combined pituitary hormone deficiencies. Endocr Rev 2002, 23:431-442.
24. Olson LE, Dasen JS, Ju BG, et al.: Paired-like repression/activation in pituitary development. Recent Prog Horm Res 2003, 58:249-261.
25. Dasen JS, O'Connell SM, Flynn SE, et al.: Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell 1999, 97:587-598.
26. Keegan CE, Camper SA: Mouse knockout solves endocrine puzzle and promotes new pituitary lineage model. Genes Dev 2003, 17:677-682.
27. Pulichino AM, Vallette-Kasic S, Tsai JPY, et al.: Tpit determines alternate fates during pituitary cell differentiation. Genes Dev 2003, 17:738-747. Using mouse knockout and transgenic gain-of-function experiments, we have shown the dual roles of Tpit as positive regulator of the corticotroph and melanotroph lineages and as negative regulator of the gonadotroph fate. This paper is the first to propose a simple model of relations between all pituitary lineages.
28. Lamolet B, Pulichino AM, Lamonerie T, et al.: A pituitary cell-restricted T-box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Cell 2001, 104:849-859.
29. Poulin G, Turgeon B, Drouin J: NeuroD1/BETA2 contributes to cell-specific transcription of the POMC gene. Mol Cell Biol 1997, 17:6673-6682.
30. Poulin G, Lebel M, Chamberland M, et al.: Specific protein:protein interaction between basic Helix-Loop-Helix transcription factors and homeoproteins of the Pitx family. Mol Cell Biol 2000, 20:4826-4837.
31. Vallette-Kasic S, Figarella-Branger D, Grino M, et al.: Differential regulation of proopiomelanocortin and pituitary-restricted transcription factor (TPIT), a new marker of normal and adenomatous human corticotrophs. J Clin Endocrinol Metab 2003, 88:3050-3056. Expression of Tpit is shown to correlate closely with POMC expression in normal pituitary and pituitary tumors.
32. Lamolet B, Poulin G, Chu K, et al.: Tpit-independent function of NeuroD1 (BETA2) in pituitary corticotroph differentiation. 2003, submitted. The importance of NeuroD1 (BETA2) in pituitary cell differentiation is shown using gene knockout. NeuroD1 deficiency leads to a delay of 3 days in corticotroph differentiation that corresponds to the window of high NeuroD1 expression in corticotrophs.
33. Pulichino AM, Vallette-Kasic S, Couture C, et al.: Human and mouse Tpit gene mutations cause early onset pituitary ACTH deficiency. Genes Dev 2003, 17:711-716. Both mouse and human Tpit loss of function is associated with isolated adrenocorticotropic deficiency and secondary adrenal insufficiency. The mouse closely reproduces the human pathology.
34. Zhao L, Bakke M, Krimkevich Y, et al.: Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development 2001, 128:147-154.
35. Ingraham HA, Lala DS, Ikeda Y, et al.: The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. Genes Dev 1994, 8:2302-2312.
36. Fowkes RC, Burrin JM: Steroidogenic factor-1: a key regulator of gonadotroph gene expression. J Endocrinol 2003, 177:345-350.
37. Lin SC, Li S, Drolet DW, et al.: Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope. Development 1994, 120:515-522.
38. Gordon DF, Woodmansee WW, Black JN, et al.: Domains of Pit-1 required for transcriptional synergy with GATA-2 on the TSH beta gene. Mol Cell Endocrinol 2002, 196:53-66. The authors have investigated in detail the requirements for positive interactions between Pit1 and GATA-2 that contribute to thyrotroph gene expression.
39. Scully KM, Gleiberman AS, Lindzey J, et al.: Role of estrogen receptor-alpha in the anterior pituitary gland. Mol Endocrinol 1997, 11:674-681.
40. Szeto DP, Rodriguez-Esteban C, Ryan AK, et al.: Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev 1999, 13:484-494.
41. Tremblay JJ, Marcil A, Gauthier Y, et al.: Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain. EMBO J 1999, 18:3431-3441.
42. Tremblay JJ, Drouin J: Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone β gene transcription. Mol Cell Biol 1999, 19:2567-2576.
43. Zakaria MM, Jeong KH, Lacza C, et al.: Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter. Mol Endocrinol 2002, 16:1840-1852.
44. Sarapura VD, Strouth HL, Wood WM, et al.: Activation of the glycoprotein hormone alpha-subunit gene promoter in thyrotropes. Mol Cell Endocrinol 1998, 146:77-86.