Synthesis of flavanones using nanocrystalline MgO

Tetrahedron Letters

Volumn 46, Issue 8, 2005, Pages 1369-1371

  Choudary, B M ^a   Ranganath, K V S ^a   Yadav, Jagajit ^a   Lakshmi Kantam, M ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

2 Hydroxyacetophenone; Chalcone; Flavanone; Isomerization; Nanocrystalline MgO

Indexed keywords

ACETOPHENONE DERIVATIVE; BENZALDEHYDE DERIVATIVE; CHALCONE DERIVATIVE; FLAVANONE DERIVATIVE; MAGNESIUM OXIDE;

ARTICLE; CATALYST; CLAISEN CONDENSATION; DRUG SYNTHESIS; ISOMERIZATION; SUBSTITUTION REACTION;

EID: 13244291574     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.12.078     Document Type: Article

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23. General experimental and reusability procedure: In a typical procedure, ethanol (5 ml), benzaldehyde (2.5 mmol), and 2-hydroxyacetophenone (3.0 mmol) were refluxed with stirring in the presence of NAP-MgO (0.100 g). The reaction was continued until completion, as monitored by TLC and also by GC according to the reference b. The catalyst was removed by filtration and the filtrate was concentrated to obtain the crude product, which was purified by column chromatography (hexane/ethyl acetate, 8/2, v/v) using silica gel. The yield of flavanone is 0. 4872 g. The reusability of the catalyst was assessed as follows using the experimental conditions described above after activating the catalyst at 250°C for 1 h. After completion of the reaction, the catalyst was allowed to settle and the supernatant solution was pumped out from the reaction flask. The catalyst was washed with toluene and allowed to settle and the supernatant solution was pumped out. The NAP-MgO was then reused for four cycles with consistent activity