Exercise controls gene expression: The activity level of skeletal muscle modulates a range of genes that produce dramatic molecular changes-and keep us healthy

American Scientist

Volumn 93, Issue 1, 2005, Pages 28-35

  Booth, Frank W ^a   Neufer, P Darrell ^b  

^a UNIVERSITY OF MISSOURI   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION;

EID: 13244291408     PISSN: 00030996     EISSN: None     Source Type: Trade Journal    
DOI: 10.1511/2005.1.28     Document Type: Article

References (11)

1. Booth, F. W., and K. M. Baldwin. 1996. Muscle plasticity: Energy demand/supply processes. In: Handbook of Physiology: Section 12: Integration of Motor, Circulatory, Respiratory, and Metabolic Control during Exercise, ed. L. B. Rowell and J. T. Shepherd. New York: Oxford University Press. pp. 1075-1123.
2. Booth, F. W., M. V. Chakravarthy, S. E. Gordon and E. E. Spangenburg. 2002. Waging war on physical inactivity: Using modern molecular ammunition against an ancient enemy. Journal of Applied Physiology 93:3-30.
3. Booth, F. W., M. V. Chakravarthy and E. E. Spangenburg. 2002. Exercise and gene expression: Physiological regulation of the human genome through physical activity. Journal of Physiology 543:399-411.
4. Chakravarthy, M. V., and F. W. Booth. 2003. Hot Topics: Exercise. Philadelphia: Elsevier.
5. Chakravarthy, M. V., and F. W. Booth. 2004. Eating, exercise, and "thrifty" genotypes: Connecting the dots toward an evolutionary understanding of modern chronic diseases. Journal of Applied Physiology 96:3-10.
6. Fluck, M., and H. Hoppeler. 2003. Molecular basis of skeletal muscle plasticity-from gene to form and function. Reviews of Physiology, Biochemistry and Pharmacology 146:159-216.
7. Holloszy, J. O. 2003. A forty-year memoir of research on the regulation of glucose transport into muscle. American Journal of Physiology. Endocrinology and Metabolism 284:E453-E467.
8. Musi, N., H. Yu and L. J. Goodyear. 2003. AMP-activated protein kinase regulation and action in skeletal muscle during exercise. Biochemical Society Transactions 31:19111-19195.
9. Pattison, J. S., L. C. Folk, R. W. Madsen, T. E. Childs, E. E. Spangenburg and F. W. Booth. 2003. Expression profiling identifies dys-regulation of myosin heavy chains IIb and IIx during limb immobilization in the soleus muscles of old rats. Journal of Physiology 553(2):357-68.
10. Pilegaard, H., G. A. Ordway, B. Saltin and P. D. Neufer. 2000. Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. American Journal of Physiology: Endocrinology and Metabolism 279:E806-E814.
11. Williams, R. S., and P. D. Neufer. 1996. Regulation of gene expression in skeletal muscle by contractile activity. In: Handbook of Physiology: Section 12: Integration of Motor, Circulatory, Respiratory, and Metabolic Control during Exercise, ed. L. B. Rowell and J. T. Shepherd. Oxford University Press: New York. pp. 1124-1150.