SH2 and SH3 domains

Current Biology

Volumn 3, Issue 7, 1993, Pages 434-442

  Pawson, T ^a   Schlessingert, J ^b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 13244284809     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-9822(93)90350-W     Document Type: Review

References (64)

1. Growth factor signaling by receptor tyrosine kinases
2. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling molecules
3. SH2 and SH3 domains: from structure to function
4. Signaling through SH2 and SH3 do mains
5. Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
6. The tyrosine phosphorylated carboxy terminus of the EGF receptor is a binding site for GAP and PLCγ
7. Identification of two C-terminal autophosphorylation sites in the PDGF Preceptor: involvement in the interaction with phospholipase C-γ
8. Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet derived growth factor receptor P subunit and are required for binding of phospholipase Cγ and a 64-kilodalton protein, respectively
9. The 64 Kd protein that associates with the PDGF receptor subunit via tyrosine 1009 is the SH2 containing phosphotyrosine phosphatase Syp/SH-PTP2/PTPID/SH-PTP3
10. Identification of two juxtamembrane autophosphorylation sites in the PDGF Preceptor: involvement in the interaction with Src family tyrosine kinases
11. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ 1 phosphorylation on tyrosine residues 783 and 1254
12. PI-3 kinase is activated by association with IRS-1 during insulin stimulation
13. PI-3 kinase is activated by phosphopeptides that bind to the SH2 domains of the 85 kDa subunit
14. Oncogenes and signal transduction
15. SH2 domains recognize specific phosphopeptide sequences
16. SH2 domains exhibit high affinity binding to tyrosine phosphorylated peptides yet also exhibit rapid dissociation and exchange
17. Interaction between SH2 domains and tyrosine phosphorylated PDGFβ receptor sequences: Analysis of kinetic parameters by a novel biosensor based approach
18. SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of tyr 992 as the high-affinity binding site for SH2 domains of phospholipase C-γ
19. A tyrosine-phosphorylated carboxy-terminal peptide of the fi broblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-γl
20. The SH2/SH3 domain containing protein GRB2 interacts with tyrosine phosphorylated IRS-1 and She: Implications for insulin control of ras signaling
21. Regulation of c-Src tyrosine kinase activity by the Src SH2 domain
22. Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine phosphorylated peptides
23. Binding of a high affinity phosphotyrosyl peptide in the src SH2 domain: Crystal structures of the complexed and peptide-free forms
24. lck
25. Identification of residues in the βPDGF- receptors that confer specificity for binding to PLC-γl
26. A novel viral oncogene with structural similarity to phospholipase C
27. Homology of a yeast actin-binding protein to signal transduction proteins and myosin-1
28. The heavy chain of Acanthamoeba myosin 113 is a fusion of myosin like and non-myosin like sequences
29. Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells
30. N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl
31. Identification of a protein that binds to the SH3 region of AN and is similar to Bcr and GAP-rho
32. SH3 domains direct cellular localization of signaling molecules
33. The v-Src SH3 domain bind phosphatidylinositol 3′-kinase
34. Crystal structure of a Src homology 3 (SH3 domain)
35. Solution structure of the SH3 domain of Src and identification of its ligand binding site
36. Structure of P13K SH3 domain and analysis of the SH3 family
37. Solution structure and ligand-binding site of the SH3 domain of the p85αsubunit of phosphatidylinositol 3-kinase
38. Ras1 and putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
39. The son of sevenless gene product A putative activator of Ras
40. Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of Ras.
41. Human Sosl: a guanine nucleotide exchange factor for Ras that binds to GRB2
42. Signal transduction during C.elegans vulval inducation
43. C. elegans cell-signaling gene sem-5 encodes a protein with SH2 and SH3 domains
44. Ras1 activation and binds to Sevenless and Sos proteins in vitro
45. A Drosophfa SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.
46. The SH2 and SH3-containing protein GRB2 links receptor tyrosine kinases to ras signaling
47. Grb2 mediates the EGF-dependent acativation of guanine nucleotide exchange on Ras
48. The SH2 and SH3 domains of mammalian Grb2 couple the EGF-receptor to the Ras activator mSos 1
49. Guanine nucleotide releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signaling
50. Epidermal growth factor regulates P21ras throught the formation of a complex of receptor; Grb2 adaptor protein, and Sos nucleotide exchange factor
51. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
52. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
53. Association of Shc and GRB2/sem-5 SH2 containing proteins is implicated in activation of ras pathway by tyrosine kinases
54. Insulin-induced phosphorylation of the 46- and 52 kDa Shc proteins
55. Function of Grb2 in linking the insulin receptor to Ras signaling pathway
56. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
57. The association of insulin-elicited phosphotyrosine proteins with src hology 2 domains
58. The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp
59. T-cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases
60. Motheaten and Viable motheaten mice have mutations in the haematopoietic cell phosphatase gene
61. Cockscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso