Preparation and stability of recombinant human tumor necrosis factor-α-loaded stealth nanoparticles

Yaoxue Xuebao

Volumn 39, Issue 11, 2004, Pages 939-943

  Fang, Chao ^a   Shi, Bin ^a   Pei, Yuan Ying ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Long circulating nanoparticles; Recombinant human tumor necrosis factor (rHuTNF ); Stealth nanoparticles; Uniform design

Indexed keywords

MACROGOL; TUMOR NECROSIS FACTOR ALPHA; WATER;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; GEL PERMEATION CHROMATOGRAPHY; INFRARED SPECTROSCOPY; MOLECULAR WEIGHT; NANOPARTICLE; PARTICLE SIZE; PROTON NUCLEAR MAGNETIC RESONANCE; SUSPENSION; SYNTHESIS;

CYANOACRYLATES; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; HUMANS; NANOTECHNOLOGY; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 13244278069     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Gref R, Domb A, Quellec P, et al. The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres [J]. Adv Drug Deliv Rev, 1995, 16(2-3):215-233.
2. Maeda H, Wu J, Sawa T, et al. Tumor vascular permeability and the EPR effect in macromolecular therapeutics ; a review [J]. J Controlled Release, 2000, 65(1-2):271-284.
3. Lienard D, Ewalenko P, Delmotte JJ, et al. High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma [J]. J Clin Oncol, 1992,10(1):52-60.
4. Li YP, Pei YY, Zhou ZH, et al. PEGylated polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers [J]. J Controlled Release, 2001,71(3): 287-296.
5. Li YP, Pei YY, Zhou ZH, et al. Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers; pharmacokinetics and anti-tumor effects [J]. Biol Pharm Bull, 2001,24(6):662-665.
6. Peracchia MT, Desmaele D, Couvreur P, et al. Synthesis of a novel poly (MePEG cyanoacylate-co-alkylcyanoacrylate) amphiphilic copolymer for nanoparticle technology [J]. Macromolecules, 1997,30(4):846-851.
7. Wang JZ, Fan M. Handbook of Protein Techniques [M]. Beijing; Science Press, 2000. 38-41.
8. Lin WJ, Juang LW, Lin CC. Stability and release performance of a series of pegylated copolymeric micelles [J]. Pharm Res, 2003,20(4):668-673.
9. Peracchia MT, Vauthier C, Desmaele D, et al. Pegylated nanoparticles from a novel methoxypolyethylene glycol cyanoacrylate-hexadecyl cyanoacrylate amphiphilic copolymer [J]. Pharm Res, 1998,15(4):550-556.
10. Stolnik S, Ilium L, Davis SS. Long circulating microparticulate drug carriers [J]. Adv Drug Deliv Rev, 1995,16(2-3):195-214.
11. Jang SH, Wientjes MG, Lu D, et al. Drug delivery and transport to solid tumors [J]. Pharm Res, 2003,20(9): 1337-1350.