Crystal structure of a dominant B-cell epitope from the preS2 region of hepatitis B virus in the form of an inserted peptide segment in maltodextrin-binding protein

Journal of Molecular Biology

Volumn 280, Issue 2, 1998, Pages 185-192

  Saul, F A ^a   Normand, B Vulliez Le ^a   Lema, F ^a   Bentley, G A ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

Antibody cross reactivity; Epitope conformation; Hepatitis B virus; Insertion deletion construction; PreS2

Indexed keywords

AMINO ACID; BINDING PROTEIN; EPITOPE; HEPATITIS B SURFACE ANTIGEN; MALTODEXTRIN; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ARTICLE; B LYMPHOCYTE; CROSS REACTION; CRYSTAL STRUCTURE; HEPATITIS B; PRIORITY JOURNAL;

EID: 13144256689     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.1866     Document Type: Article

References (29)

1. Brunger A.T., Kuriyan J., Karplus M. Crystallographic R factor refinement by molecular dynamics. Science. 235:1987;458-460
2. Bruss V., Lu X., Thomssen R., Gerlich W.H. Post-translational alterations in transmembrane topology of the hepatitis B virus large protein. EMBO J. 13:1994;2273-2279
3. Connolly M.J. Analytical molecular surface calculation. J. Appl. Crystallog. 16:1983;548-558
4. Delos S., Villar M.T., Hu P., Peterson D. Cloning, expression, isolation and characterisation of the pre-S domains of hepatitis B surface antigen, devoid of the S protein. Biochem. J. 276:1991;411-416
5. Elbe B.E., Mingappa V.R., Ganem D. The N-terminal (preS2) domain of a hepatitis B virus surface glycoprotein translocated across membranes by downstream signal sequences. J. Virol. 64:1990;1414-1419
6. Engh R.A., Huber R. Accurate bond and angle parameters for X-ray protein structure refinement. Acta Crystallog. sect. A. 47:1991;392-400
7. Itoh Y., Takai E., Ohnuma H., Kitajima K., Tsuda F., Machida A., Mishiro S., Nakamura T., Miyakawa Y., Mayumi M. A synthetic peptide vaccine involving the product of the pre-S(2) region of hepatitis B virus DNA protective efficacy in chimpanzees. Proc. Natl Acad. Sci. USA. 83:1986;9174
8. Kabsch W. Evaluation of single-crystal X-ray diffraction data from a position-sensitive detector. J. Appl. Crystallog. 21:1988;916-924
9. Kim H.S., Kim Y.K., Ryu S.-E., Hong H.J. Production of hepatitis B virus preS polypeptide in Escherichia coli by mutation of the 5′-end coding sequence and its purification and characterisation. Gene. 177:1996;173-177
10. Kraulis P. MOLSCRIPT a program to produce both detailed and schematic photos of protein structures. J. Appl. Crystallog. 24:1991;946-950
11. Leclerc C., Martineau P., van der Werf S., Deriaud E., Duplay P., Hofnung M. Induction of virus-neutralizing antibodies by bacteria expressing the C3 poliovirus epitope in the periplasm. J. Immunol. 144:1990;3174-3182
12. Lin Y., Liu Y.-X., Cislo T., Mason B.L., Yu M.-Y. Expression and characterisation of the preS1 peptide of hepatitis B surface antigen in Escherichia coli. J. Med. Virol. 33:1991;181-187
13. Lo-Man R., Martineau P., Hofnung M., Leclerc C. Induction of T cell responses by chimeric bacterial proteins expressing several copies of a viral T cell epitope. Eur. J. Immunol. 23:1993;2998-3002
14. Martineau P., Charbit A., Leclerc C., Werts C., O'Callaghan D., Hofnung M. A genetic system to elicit and monitor anti-peptide antibodies without peptide synthesis. Biotechnology. 9:1990;170-172
15. Martineau P., Guillet J.-G., Leclerc C., Hofnung M. Expression of heterologous peptides at two permissive sites of the MalE protein antigenicity and immunogenicity of foreign B-cell and T-cell epitopes. Gene. 113:1992;35-46
16. Meisel H., Sominskaya I., Pumpens P., Pushko P., Borisova G., Deepen R., Lu X., Spiller G.H., Kruger D.H., Grens E., Gerlich W.H. Fine mapping and functional characterisation of two immuno-dominant regions from the preS2 sequence of hepatitis B virus. Intervirology. 37:1994;330-339
17. Milich D.R., Thornton G.B., Neurath A.R., Kent S.B., Michel M.-L., Tiollais P., Chisari F.V. Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen. Science. 228:1985;1195-1199
18. Milich D.R., McLachan A., Chisari F.V., Thornton G.B. Non-overlapping T and B cell determinants on an hepatitis B surface antigen pre-S(2) region synthetic peptide. J. Expt. Med. 164:1986;532-547
19. Milich D.R., McLachlan A., Chisari F.V., Nakamura T., Thornton G.B. Two distinct but overlapping antibody binding sites in the pre-S(2) region of HBsAg localised within 11 continuous residues. J. Immunol. 137:1986;2703-2710
20. Mimms L.T., Floreani M., Tyner J., Whitters E., Rosenlof R., Wray L., Goetze A., Sarin V., Eble K. Discrimination of heptitus B viris (HBV) subtypes using monoclonal antibodies to the preS1 and preS2 domains of the viral envelope. Virology. 176:1990;604-619
21. Navaza J. AMORE an automated package for molecular replacement. Acta Crystallog. sect. A. 50:1994;157-163
22. Neurath A.R., Kent S.B.H. The pre-S region of hepadnavirus envelope proteins. Advan. Virus Res. 34:1988;65-142
23. Neurath A.R., Kent S.B.H., Strick N. Location and chemical synthesis of a pre-S gene coded immunodominant epitope of hepatitis B virus. Science. 224:1984;392-395
24. Neurath A.R., Kent S.B.H., Parker K., Prince A.M., Strick N., Brotman B., Spoul P. Antibodies to a synthetic peptide from the preS 120-145 region of the hepatitis B virus envelope are virus neutralizing. Vaccine. 4:1986;35-37
25. Quiocho F., Spurlino J.C., Rodseth L.E. Extensive features of tight oligosaccaride binding revealed in high-resolution structures of the maltodextrin transport/chemosensory system. Structure. 5:1997;997-1015
26. Saul F.A., Vulliez-le Normand B., Lema F., Bentley G.A. Crystal structure of a recombinant form of the maltodextrin-binding protein carrying an inserted sequence of a B-cell epitope from the preS2 region of hepatitis B virus. Proteins: Struct. Funct. Genet. 10:1997;1-8
27. Sominskaya I., Bichko V., Pushko P., Dreimane A., Snikere D., Pumpens P. Tetrapeptide QDPR is a minimal immunodominant epitope within the preS2 domain of hepatitis B virus. Immunol. Letters. 33:1992;169-172
28. Spurlino J.C., Lu G.-Y., Quiocho F.A. The 2.3 Å resolution structure of the maltose- or maltodextrin-binding protein, a primary receptor of bacterial active transport and chemotaxis. J. Biol. Chem. 31:1991;10657-10663
29. Vulliez-le Normand B., Saul F.A., Martineau P., Lema F., Hofnung M., Bentley G.A. Maltodextrin-binding protein hybrids carrying epitopes from the preS2 region of hepatitis B virus expression, antibody-binding and preliminary crystallographic studies. Protein Eng. 10:1997;175-180