The effect of deferoxamine on ciprofibrate-induced hepatocarcinogenesis in the rat

In Vivo

Volumn 11, Issue 6, 1997, Pages 495-498

  Sambasiva Rao, M ^a   Subbarao, V ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Hepatocarcinogenesis; Iron chelation; Peroxisome proliferators

Indexed keywords

CHELATING AGENT; CIPROFIBRATE; DEFEROXAMINE; HYDROGEN PEROXIDE; HYDROXYL RADICAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CANCER PREVENTION; CONTROLLED STUDY; IRON CHELATION; LIVER CARCINOGENESIS; MALE; NONHUMAN; RAT; TUMOR VOLUME;

EID: 13144251114     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Reddy JK and Chu R: Peroxisome proliferator-induced pleiotropic responses: pursuit of a phenomenon. Ann NY Acad Sci 804: 176-201, 1996.
2. Rao MS and Reddy JK: Hepatocarcinogenesis of peroxisome proliferators. Ann N Y Acad Sci 804: 573-587, 1996.
3. Reddy JK and Rao MS: Oxidative DNA damage caused by persistent peroxisome proliferation: its role in hepatocarcinogenesis. Mut Res 214: 63-68, 1989.
4. Hashimoto T: Individual peroxisomal β-oxidation enzymes. Ann NY Acad Sci 386: 5-12, 1982.
5. Nemali MR, Usuda N, Reddy MK, Oyasu K, Hashimoto T, Osumi T, Rao MS and Reddy JK: Comparison of constitutive and inducible levels of expression of peroxisomal β-oxidation and catalase genes in liver and extrahepatic tissue of rats. Cancer Res 48: 5316-5324, 1988.
6. Ciriolo MR, Mavelli I, Rotilio G, Borzatta V, Cristofari N and Stanzani L: Decrease of superoxide dismutase and glutathione peroxidase in liver of rats treated with hypolipidemic drugs. FEBS Lett 144: 264-268, 1989.
7. Reddy JK, Lalwani ND, Reddy MK and Qureshi SA: Excessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methyl clofenapate and other hypolipidemic peroxisome proliferators. Cancer Res 42: 259-266, 1982.
8. Conway JC, Tomaszewski KE, Olson MJ, Cattley RC, Marsman DS and Popp JA: Relationship of oxidative damage to hepatocarcinogenecity of the peroxisome proliferators di-(2-ethylhexyl)phthalate and Wy-14,643. Carcinogenesis 10: 513-519, 1989.
9. Kasai H, Okada Y, Nishimura S, Rao MS and Reddy JK: Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long term exposure to a peroxisome proliferator. Cancer Res 49: 2603-2605, 1989.
10. 2-generating peroxisomal fatty acyl-CoA oxidase. Proc Natl Acad Sci USA 92: 7080-7084, 1995.
11. Tomoaszewski KE, Agarwal DK and Melnick RL: In vitro steady state level of hydrogen peroxide after exposure of F-344 rats and female B6C3F1 mice to hepatic peroxisome proliferators. Carcinogenesis 7: 1871-1876, 1986.
12. Blakely WF, Fuciarelli AF, Wegher BJ and Dizdaroglu M: Hydrogen peroxideinduced base damage in deoxyribonucleic acid. Radiation Res 121: 338-343, 1990.
13. Haber F and Weiss J: The catalytic decomposition of hydrogen peroxide by iron salt. Proc Roy Soc Lond A Math Phys Sci 147: 332-351, 1934.
14. Pool M: Oxidants and antioxidants in proliferative senescence. Mut Res 256: 177-189, 1991.
15. Guyton KZ and Kensler TW: Oxidative mechanisms in Carcinogenesis. Br Med Bulletin 49: 523-544, 1993.
16. Rao MS, Lalwani ND and Reddy JK: Sequential histologic study of rat liver during peroxisome proliferator [4-chloro-6-(2,3-xylidino)-2-pyrimidinyl thio] acetic acid (WY-14,643)-induced Carcinogenesis. J Natl Cancer Inst 73: 983-990, 1984.
17. Elliott BM, Dodd NJF and Elcombe CR: Increased hydroxyl radical production in liver peroxisomal fractions from rats treated with peroxisome proliferators. Carcinogenesis 7: 795-799, 1986.
18. Rao MS, Lalwani ND, Watanabe TK and Reddy JK: Inhibitory effect of antioxidants ethoxyquin and 2(3)-tert-butyl-4-hydroxyanisole on hepatic tumorigenesis in rats fed ciprofibrate, a peroxisome proliferator. Cancer Res 44: 1072-1076, 1984.
19. Breimer LH: Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: the role of DNA base damage. Mol Carcinogenesis 3: 188-197, 1990.
20. Modell CB and Beck J: Long term desferrioxamine therapy in thalassemia. Ann N Y Acad Sci 232: 201-210, 1974.
21. Gutteridge JMC, Richmond R and Halliwell B: Inhibition of iron-catalysed formation of hydroxyl radicals from superoxide and lipid peroxidation by deferoxamine. Biochem J 184: 469-471, 1979.
22. Samuni A, Aronovitch J, Gadinger D, Chevian M and Csapski G: On the cytotoxicity of vitamin C and metal ions, A specific Fenton mechanism. Eur J Biochem 137: 119-129, 1983.