Novel small renin inhibitors containing 4,5- or 3,5-Dihydroxy-2-substituted-6-phenylhexanamide replacements at the P2-P3 sites

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 12, 1998, Pages 2317-2336

  Jung, Grace L ^a,b   Anderson, Paul C ^a   Bailey, Murray ^a   Baillet, Monique ^a   Bantle, Gary W ^a   Berthiaume, Sylvie ^a   Lavallée, Pierre ^a   Llinas Brunet, Montse ^a   Thavonekham, Bounkham ^a   Thibeault, Diane ^a   Simoneau, Bruno ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^b Nortran Pharmaceuticals Inc   (Canada)

Author keywords

Antihypertension; N terminal dipeptide replacements; Renin inhibitors

Indexed keywords

RENIN INHIBITOR;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIASTEREOISOMER; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMA RENIN ACTIVITY; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 13044292051     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)80011-4     Document Type: Article

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