Nitrofen-induced congenital malformations of the heart and great vessels in rats: An animal model

Journal of Pediatric Surgery

Volumn 34, Issue 12, 1999, Pages 1782-1786

  Kim, Won Gon ^a,b   Suh, Jung Wook ^a   Chi, Je Geun ^a  

^a Seoul National University   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

Animal model; Congenital cardiovascular anomalies; Nitrofen

Indexed keywords

NITROFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ARCH ANOMALY; ARTICLE; CARDIOVASCULAR MALFORMATION; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; FALLOT TETRALOGY; FEMALE; FETUS; GREAT BLOOD VESSEL; HEART VENTRICLE SEPTUM DEFECT; LUNG ATRESIA; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RAT;

EID: 12944288318     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3468(99)90312-3     Document Type: Article

References (16)

1. Costlow RD, Manson JM: The heart and diaphragm: Target organs in the neonatal death induced by nitrofen (2,4-dichlorophenyl-p-nitrophenyl ether). Toxicology 20:209-227, 1981
2. Tenbrinck R, Tibboel D, Gaillard JLJ, et al: Experimentally induced congenital diaphragmatic hernia in rats. J Pediatr Surg 25:426-429, 1990
3. Kluth D, Kangah R, Reich P, et al: Nitrofen-induced diaphragmatic hernias in rats: An animal model. J Pediatr Surg 25:850-854, 1990
4. Sluiter W, Bos AP, Silveri F, et al: Nitrofen-induced diaphragmatic hernias in rats: Pulmonary antioxidant enzyme activities. Pediatr Res 32:394-398, 1992
5. Tovar JA, Alfonso LF, Aldazabal, et al: The kidney in the fetal rat model of congenital diaphragmatic hernia induced by nitrofen. J Pediatr Surg 27:1356-1360, 1992
6. Daston GP, Rehnberg BF, Carvet B, et al: Functional teratogens of the rat kidney. II. Nitrofen and ethylenethiourea. Fundam Appl Toxicol 11:401-415, 1988
7. Kavlock RJ, Hoyle BR, Rehnberg BF, et al: The significance of the dilated renal pelvis in the nitrofen-exposed rat fetuses: Effects on morphology and function. Toxicol Appl Pharmacol 94:287-296, 1988
8. Lau C, Cameron AM, Irsula O, et al: Effects of prenatal nitrofen exposure on cardiac structure and function in the rat. Toxicol Appl Pharmacol 86:22-32, 1986
9. Taleporos P, Salgo MP, Oster G: Teratologic action of a bis(ichloroacetyl) diamine on rats - patterns of malformations produced in high incidence at time-limited periods of development. Toxicology 18:5-16, 1978
10. Wilson JG: Embryological considerations in teratology, in Wilson JG (ed): Teratology Principles and Techniques. Chicago, IL, The University of Chicago Press, 1965, pp 251-261
11. Fox MH, Goss CM: Experimental production of a syndrome of congenital cardiovascular defects in rats. Anat Rec 124:189-208, 1956
12. Fox MH: Genetic transmission of congenital membranous ventricular septal defects in selectively inbred substrains of rats. Cir Res 20:422-433, 1967
13. Inomata N, Yasuda M: Prevalence and types of spontaneous interventricular septal defects in rat fetuses. Exp Anim 20:15-20, 1971
14. Haring OM: Cardiac malformations in rats induced by exposure of the mother to carbon dioxide during pregnancy. Circ Res 8:1218-1227, 1960
15. Lev M, Bharati S, Meng CCL, et al: A concept of double outlet right ventricle. J Thorac Cardiovasc Surg 64:275-281, 1972
16. Celoria GC, Patton RB: Congenital absence of the aortic arch. Am Heart J 58:407-413, 1959