Unreliability of current assays to detect cobalamin deficiency: "Nothing gold can stay"

Blood

Volumn 105, Issue 3, 2005, Pages 910-911

  Green, Ralph ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLMALONIC ACID;

AMINO ACID BLOOD LEVEL; CARDIOVASCULAR RISK; COST EFFECTIVENESS ANALYSIS; CYANOCOBALAMIN DEFICIENCY; DIFFERENTIAL DIAGNOSIS; DOSE RESPONSE; FOLIC ACID DEFICIENCY; HUMAN; HYPERHOMOCYSTEINEMIA; LABORATORY TEST; METHYLMALONIC ACIDEMIA; NEUROLOGIC DISEASE; PRIORITY JOURNAL; REVIEW; VITAMIN BLOOD LEVEL;

EID: 12844286824     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-11-4293     Document Type: Review

References (5)

1. Green R. Metabolite assays in cobalan in and folate deficiency. Baillieres Clin Haematol. 1995;8:533-566.
2. Carmel R, Brar S, Agrawal A, Penha PD. Failure of assay to identify low cobalamin concentrations. Clin Chem. 2000;46:2017-2018.
3. Allen RH, Stabler SH, Savage DG, Lindenbaum J. Diagnosis of cobalamin deficiency I: usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J Hematol. 1990;34:90-98.
4. Green R. Screening for vitamin B12 deficiency: caveat emptor. Ann Intern Med. 1996;124:509-511.
5. Frost R. Nothing gold can stay. 1926.