Low molecular weight poly(ethylene glycol) as an environmentally benign solvent for pharmaceutical crystallization and precipitation

Crystal Growth and Design

Volumn 5, Issue 1, 2005, Pages 85-92

  Wang, Xing ^a   Ponder, Celia Steward ^b   Kirwan, Donald J ^a  

^a University of Virginia   (United States)

^b Corning Corporation ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PROPANOL; ALKANOL; AMINO ACID; GLUTAMIC ACID; IBUPROFEN; MACROGOL; METHANOL; SALICYLIC ACID; SOLVENT;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; MOLECULAR WEIGHT; PRECIPITATION; VISCOSITY;

EID: 12844281633     PISSN: 15287483     EISSN: None     Source Type: Journal    
DOI: 10.1021/cg034208i     Document Type: Article

References (27)

1. Profile of the Pharmaceutical Industry; U. S. Environmental Protection Agency: Washington, DC, 1997.
2. Anastas P. T. In Benign by Design: Alternative Synthetic Design for Pollution Prevention; Anastas, P. T., Farris, C. A., Eds.; American Chemical Society: Washington, DC, 1997.
3. Leininger, N. F.; Clontz, R.; Gainer, J. L.; Kirwan, D. J. In ACS Symposium Series 819; Abraham, M. L., Moens, L., Eds.; American Chemical Society: Washington, DC, 2002; pp 208-223.
4. Leininger, N. F.; Clontz, R.; Gainer J. L.; Kirwan D. J. Chem. Eng. Comm. 2003, 190, 431-443.
5. Leininger, N. F.; Gainer, J. L.; Kirwan, D. J. AIChE J. 2004, 50, 511-517.
6. Lewis, R. J. S. In SAXS Dangerous Properties of Industrial Materials, 10th ed.; Wiley and Sons: New York, 2000.
7. The Merck Index, 12th ed.; Merck and Co.: Rathway, NJ, 1996.
8. Zalipsky, S.; Harris, J. M. In Poly(ethylene glycol): Chemistry and Biological Applications; Harris J. M., Zalipsky, S., Eds.; American Chemical Society: Washington, DC, 1997: pp 1-13.
9. Leininger, N., Ph.D. Dissertation, Polyglycol-Water Solutions as Environmentally Benign Reaction Solvents, Department of Chemical Engineering, University of Virginia, 2003.
10. Wang, X., M.S. Thesis, Precipitation of Pharmaceuticals with Enviromentally Benign Polyglycols, Department of Chemical Engineering, University of Virginia, 2003.
11. Steward, C., M.S. Thesis, Crystallization Kinetics of Glutamic Acid, Chemical Engineering Department, University of Virginia, 1997.
12. Altenburger, C., B. S. Thesis, Amino Acid Solubility in Aqueous Polyethylene Glycol Solutions, Department of Chemical Engineering, University of Virginia, 1997.
13. McPherson, A. J. Biol. Chem. 1976, 251, 6300-6303.
14. Kuznetsov, Y. G.; Malkin, A. J.; McPherson, A. J. Cryst. Growth, 2001, 232, 30-39.
15. Ray, W. J.; Bracker, C. E. J. Cryst. Growth, 1986, 76, 562-576.
16. Albertsson, P.a. In Partition of Cell Particles and Macromolecules, 3rd ed.; J. Wiley: New York, 1986.
17. King, R. S.; Blanch, H. W.; Prausnitz, J. M. AIChE J., 1988, 34, 1585.
18. Wilkie, R. A.; Montague, C. Counting on Cleanliness Measurement Technology, Precision Cleaning Mag Sept., 1994.
19. Boullard, O.; Leblanc, H.; Besson, B., "Salicylic Acid", in Ullmann's Encyclopedia of Industrial Chemistry, 7th ed.; Ullmann, F., Eds.; Wiley-VCH: New York, 2004.
20. Thomas, M. R. Salicylic Acid and Related Compounds, 3rd ed.; Kirk-Othmer Encyclopedia of Chemical Technology; J. Wiley: New York, 1982; Vol. 20.
21. Orella, C. J.; Kirwan, D. J. Ind. Eng. Chem. Res. 1991, 30, 1040-1045.
22. Gmehling, J.; Li, J.; Schiller, M. Ind. Eng. Chem. Res. 1993, 32, 178-193.
23. Myerson, A. S. In Handbook of Industrial Crystallization; Butterworth- Heinemann: New York, 1992.
24. Mahajan, A.; Kirwan, D. J. J. Cryst. Growth 1994, 144, 281-290.
25. Hulburt, H. M.; Katz, S. Chem. Eng. Sci., 1964, 19, 555-574.
26. Tavare, N. S.; Garside, J. Chem. Eng. Sci. 1993, 48, 475-488.
27. Tavara, N. S. In Industrial Crystallization: Process Simulation Analysis and Design; Plenum Press: New York, 1995.