Reduction in the initial-burst release by surface crosslinking of PLGA microparticles containing hydrophilic or hydrophobic drugs

Drug Development and Industrial Pharmacy

Volumn 31, Issue 1, 2005, Pages 43-57

  Thote, Amol J ^a   Chappell Jr , John T ^a   Gupta, Ram B ^a   Kumar, Rajesh ^b  

^a AUBURN UNIVERSITY   (United States)

^b ALKERMES INC   (United States)

Author keywords

Controlled drug release; Dexamethasone; Dexamethasone phosphate; EGDMA; HPLC; PLGA; Sustained release formulations; Tri(EG)DMA; UV surface crosslinking

Indexed keywords

DEXAMETHASONE; DEXAMETHASONE SODIUM PHOSPHATE; ETHYLENE GLYCOL DIMETHACRYLATE; POLYGLACTIN; TRIETHYLENE GLYCOL DIMETHACRYLATE; UNCLASSIFIED DRUG;

ARTICLE; COACERVATION; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; DRUG STRUCTURE; EVAPORATION; MICROEMULSION; PARTICLE SIZE; PHASE SEPARATION; SUSTAINED RELEASE PREPARATION; ULTRAVIOLET RADIATION;

CHEMISTRY, PHYSICAL; CROSS-LINKING REAGENTS; DEXAMETHASONE; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; KINETICS; METHACRYLATES; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET; SURFACE PROPERTIES;

EID: 12844273562     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-43985     Document Type: Article

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