Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3′-C-ethynyluridine (EUrd) and 3′-C- ethynylcytidine (ECyd)

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 4, 2005, Pages 1249-1260

  Hrdlicka, Patrick J ^a   Jepsen, Jan S ^b   Nielsen, Claus ^c   Wengel, Jesper ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^c STATENS SERUM INSTITUT   (Denmark)

Author keywords

Antitumor; EUrd; TAS 106; Uridine cytidine kinase

Indexed keywords

(2,3,5 TRI O ACETYL 3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 2 THIOCYTOSINE; (2,3,5 TRI O ACETYL 3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 4 THIOURACILCYANURIC ACID; (3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 2 THIOCYTOSINE; 1 (2,3,5 TRI O ACETYL 3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 4 N BENZOYLCYTOSINE; 1 (2,3,5 TRI O ACETYL 3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 5 AZACYTOSINE; 1 (2,3,5 TRI O ACETYL 3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 5 AZAURACIL; 1 (2,3,5 TRI O ACETYL 3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 5 BROMOURACIL; 1 (2,3,5 TRI O ACETYL 3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 5 CHLOROURACIL; 1 (2,3,5 TRI O ACETYL 3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 5 DEAZAURACIL; 1 (2,3,5 TRI O ACETYL 3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 5 HYDROXYURACIL; 1 (2,3,5 TRI O ACETYL 3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 5 IODOURACIL; 1 (2,3,5 TRI O ACETYL 3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL)CYANURIC ACID; 1 (2,3,5 TRI O ACETYL 3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL)URACIL; 1 (3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 4 THIOURACIL; 1 (3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 5 BROMOURACIL; 1 (3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 5 CHLOROURACIL; 1 (3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 5 HYDROXYURACIL; 1 (3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL) 5 IODOURACIL; 1 (3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL)CYANURIC ACID; 1 (3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL)URACIL; 3' C ETHYNYLURIDINE; 3' ETHYNYLCYTIDINE; ANTINEOPLASTIC AGENT; DIACETONE ALPHA DEXTRO GLUCOSE; GLUCOSE DERIVATIVE; NUCLEIC ACID BASE; UNCLASSIFIED DRUG;

ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALE; PROSTATE CANCER;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYTIDINE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; URIDINE;

EID: 12844271200     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.11.054     Document Type: Article

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