Effects of diethylene glycol butyl ether and butoxyethoxyacetic acid on rat and human erythrocytes

Toxicology Letters

Volumn 156, Issue 1 SPEC. ISS., 2005, Pages 95-101

  Udden, M M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Butoxyethoxyacetic acid; Diethylene glycol butyl ether; Glycol ethers; Hemolysis; Rat red blood cells

Indexed keywords

ACETIC ACID DERIVATIVE; BUTOXYETHOXYACETIC ACID; DIETHYLENE GLYCOL BUTYL ETHER; ETHER DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; CELL DAMAGE; CELL SIZE; CELL STRUCTURE; CELL VOLUME; CONFERENCE PAPER; CONTROLLED STUDY; ERYTHROCYTE; EXPOSURE; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; SPHEROCYTOSIS;

EID: 12844270842     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2003.09.021     Document Type: Conference Paper

References (20)

1. C.S. Auletta, R.E. Schroeder, W.J. Krasavage, and C.R. Stack Toxicology of diethylene glycol butyl ether R. dermal subchronic/reproduction study in rats J. Am. Coll. Toxicol. 12 1993 161 168
2. P. Beyrouty, B. Broxup, G. Losos, K. Robinson, L.P.J. Maurissen, M.W. Gill, and C.R. Stack Toxicology of diethylene glycol butyl ether 5. Dermal subchronic neurotoxicity study in rats J. Am. Coll. Toxicol. 12 1993 169 174
3. R.A. Boatman, D.B. Schum, D. Guest, and C.R. Stack Toxicology of diethylene glycol butyl ether 2. Disposition studies with 14C-diethylene glycol butyl ether acetate after dermal application to rats J. Am. Coll. Toxicol. 12 1993 145 154
4. R.J. Boatman, and J.B. Knaak Ethers of ethylene glycol and derivatives E. Bingham B. Cohrssen C.H. Powell Patty's Toxicology 5th ed. 2001 Wiley New York 73 271
5. J.V. Dacie, and S.M. Lewis Practical Haematology 5th ed. 1975 Churchill Livingstone New York
6. B. Deuticke The transmembrane exchange of chloride with hydroxyl and other anions in mammalian red blood cells Oxygen Affinity of Hemoglobin and Red cell acid Base Status 1972 Munskgaard Copenhagen pp. 307-316
7. B. Deuticke Monocarboxylate transport in red blood cells: kinetics and chemical modification Meth. Enzymol. 173 1989 300 329
8. B.I. Ghanayem An overview of the hematotoxicity of glycol ethers Occup. Hyg. 2 1996 253 268
9. B.I. Ghanayem, L.T. Burka, and H.B. Matthews Metabolic basis of ethylene glycol monobutyl ether (2-butoxyethanol) toxicity: role of alcohol and aldehyde dehydrogenases J. Pharmacol. Exp. Ther. 242 1987 222 231
10. B.I. Ghanayem, and C.A. Sullivan Assessment of the haemolytic activity of 2-butoxyethanol and its major metabolite, butoxyacetic acid, in various mammals including humans Hum. Exp. Toxicol. 12 1993 305 311
11. R.J. Gingell, R.A. Boatman, R.A. Corley, J.B. Knaak, K.A. Rosica, and R.C. Wise Toxicology of diethylene glycol butyl ether Occup. Hyg. 2 1996 293 300
12. R.J. Gingell, W.J. Krasavage, R.C. Wise, J.B. Knaak, J. Bus, W.B. Gibson, and C.R. Stack Toxicology of diethylene glycol butyl ether 1. Exposure and risk assessment J. Am. Coll. Toxicol. 12 1993 139 144
13. B.B. Gollapudi, V.A. Linscombe, M.L. McClintock, A.K. Sinha, and C.R. Stack Toxicology of diethylene glycol butyl ether 3. Genotoxicity evaluation in an in vitro gene mutation assay and an in vitro cytogenetic test J. Am. Coll. Toxicol. 12 1993 155 159
14. J. Lee, C.H. Trad, and D.A. Butterfield Electron paramagnetic resonance studies of the effects of methoxyacetic acid, a teratologic toxin, on human erythrocyte membranes Toxicology 83 1993 131 148
15. K. Mori, K. Fujishiro, and N. Inoue Effects of ethylene glycol monomethyl ether and methoxyacetic acid on human erythrocyte membranes Res. Com. Subst. Abuse 10 1995 237 249
16. E.A. O'Rear, L.V. McIntire, B.O. Shah, and E.C. Lynch Use of a rheological technique to evaluate erythrocyte membrane alterations J. Rheol. 23 1979 721 733
17. M.M. Udden Rat erythrocyte morphological changes after gavage dosing with 2-butoxyethanol: a comparison to the in vitro effects of butoxyacetic acid on rat and human erythrocytes J. Appl. Toxicol. 20 2000 381 387
18. M.M. Udden In vitro sub-hemolytic effects of butoxyacetic acid on human and rat erythrocytes Toxicol. Sci. 69 2002 258 264
19. M.M. Udden, E.A. O'Rear, H. Kegel, L.V. McIntire, and E.C. Lynch Decreased deformability of erythrocytes and increased intracellular calcium in patients with chronic renal failure Clin. Hemorheol. 4 1984 461 471
20. M.M. Udden, and C.S. Patton Hemolysis and decreased deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol: I. Sensitivity in rats and resistance in normal humans J. Appl. Toxicol. 14 1994 91 96