Carbidopa/levodopa-loaded biodegradable microspheres: In vivo evaluation on experimental Parkinsonism in rats

Journal of Controlled Release

Volumn 102, Issue 3, 2005, Pages 689-697

  Arica, Betül ^a   Kaş, H Süheyla ^a,b   Moghdam, Amir ^a   Akalan, Nejat ^a   Hincal, A Atilla ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b Erdem Kent   (Turkey)

Author keywords

Biodegradable polymers (l PLA, d,l PLA and PLAGA); Carbidopa; Experimental Parkinsonism in rats; Levodopa; Microspheres

Indexed keywords

BIODEGRADATION; BRAIN; DISEASES; DRUG DOSAGE; EMULSIFICATION; ENCAPSULATION; IMPLANTS (SURGICAL); PHYSIOLOGICAL MODELS; POLYVINYL ALCOHOLS;

CARBIDOPA (CD); DRUG LOADING; INTRACEREBRAL TREATMENT; LEVODOPA (LD); MICROSPHERES; PARKINSON'S DISEASE;

DRUG PRODUCTS;

APOMORPHINE; CARBIDOPA; CARBOXYMETHYLCELLULOSE; EMULSIFYING AGENT; LEVODOPA; MICROSPHERE; OLEATE SODIUM; ORGANIC COMPOUND; OXIDOPAMINE; POLY(LEVO LACTIDE); POLYGLACTIN; POLYLACTIDE; POLYMER; POLYVINYL ALCOHOL; SOLVENT; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIODEGRADABILITY; BRAIN INJURY; CIRCLING BEHAVIOR; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORPUS STRIATUM; DRUG RELEASE; DRUG SYNTHESIS; ENCAPSULATION; EVAPORATION; EXPERIMENTAL MODEL; IMPLANTATION; IN VITRO STUDY; INJECTION; MALE; MORPHOLOGY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SCORING SYSTEM; STATISTICAL SIGNIFICANCE;

ANIMALS; BIOTRANSFORMATION; CARBIDOPA; DRUG EVALUATION, PRECLINICAL; LEVODOPA; MALE; MICROSPHERES; PARKINSONIAN DISORDERS; RATS;

EID: 12844267548     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.11.004     Document Type: Article

References (23)

1. R. Langer Polymer implants for drug delivery in the brain J. Control. Release 16 1991 53 60
2. B. ArIca, H.S. Kaş, A. Moghdam, N. Akalan, and A.A. HIncal Evaluation of encapsulated carbidopa/levodopa releasing microspheres on experimental Parkinsonism in rats Eur. J. Pharm. Sci. 8 1999 5 6
3. R.J. Tamargo, and H. Brem Drug delivery to the central nervous system: a review Neurosurg. Q. 2 1992 259 279
4. R.J. Tamargo, A.K. Sills, C.S. Reinhard, M.L. Pinn, D.M. Long, and H. Brem Interstitial delivery of dexamethasone in the brain for the reduction of peritumoral edema J. Neurosurg. 74 1991 956 961
5. C.E. Krewson, M.L. Klarman, and W.M. Saltzman Distribution of nerve growth factor following direct delivery to brain interstitium Brain Res. 680 1-2 1995 196 206
6. A. McRae-Degueurce, S. Hjorth, D.L. Dillon, D.W. Mason, and T.R. Tice Implantable microencapsulated dopamine (DA): a new approach for slow-release DA delivery into brain tissue Neurosci. Lett. 92 1988 303 309
7. A. McRae, S. Hjorth, D.W. Mason, D.L. Dillon, and T.R. Tice Microencapsulated dopamine (DA)-induced restitution of function in 6-OHDA denervated rat striatum in vivo: comparison between two microsphere excipients J. Neural Transpl. Plast. 2 1991 165 173
8. D. Maysinger, V. Jalsenjak, S. Stolnik, and I. Jalsenjak Release of l-Dopa from HSA microspheres into the rat brain: in vitro and in vivo characterization by microdialysis T.L. Whateley Microencapsulation of Drugs 1992 Harwood Academic Publisher Switzerland 269 275
9. M.J. During, A. Freese, B.A. Sabel, W.M. Saltzman, A. Deutch, R.H. Roth, and R. Langer Controlled release of dopamine from a polymeric brain implant: in vivo characterization Ann. Neurol. 25 1989 351 356
10. J.J. Vallbacka, J.N. Nobrega, and M.V. Sefton Tissue engineering as a platform for controlled release of therapeutic agents: implantation of microencapsulated dopamine producing cells in the brains of rats J. Control. Release 72 2001 93 100
11. J.R. Bianchine, and B. McGhee MPTP and Parkinsonism Ration. Drug Ther. 19 1985 5 7
12. J.E.F. Reynolds, and Martindale The Extra Pharmacopoeia 29th Edition 1989 The Pharmaceutical Press London
13. B. ArIca, H.S. Kaş, and A.A. HIncal Factors influencing the formulation parameters of biodegradable carbidopa microspheres 11th International Symposium on Microencapsulation 1997 55
14. 2 factorial design A.A. HIncal H.S. Kaş Biomedical Science and Technology, Recent Developments in the Pharmaceutical and Medical Sciences 1998 Plenum Press New York 41 49
15. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 1982 Academic Press Sydney
16. P. Menei, J.M. Pean, V. Nerriere-Daguin, C. Jollivet, P. Brachet, and J.P. Benoit Intracerebral implantation of NGF-releasing biodegradable microspheres protects striatum against excitotoxic damage Exp. Neurol. 161 2000 259 272
17. U. Ungerstedt, and G.W. Arbuthnott Quantitative recording of rotational behaviour in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system Brain Res. 24 1970 485 493
18. S.R. Winn, L. Wahlberg, P.A. Tresco, and P. Aebischer An encapsulated dopamine-releasing polymer alleviates experimental Parkinsonism in rats Exp. Neurol. 105 1989 244 250
19. C. Gouhier, S. Chalon, A. Aubert-Pouessel, M.C. Venier-Julienne, C. Jollivet, J.P. Benoit, and D. Guilloteau Protection of dopaminergic nigrostriatal afferents by GDNF delivered by microspheres in a rodent model of Parkinson's disease Synapse 44 2002 124 131
20. P. Menei, M. Boisdron-Celle, A. Croue, G. Guy, and J.P. Benoit Effect of stereotactic implantation of biodegradable 5-fluorouracil-loaded microspheres in healthy and C6 glioma-bearing rats Neurosurg. 39 1996 117 123
21. J. Veziers, M. Lesourd, C. Jollivet, C. Montero-Menei, J.P. Benoit, and P. Menei Analysis of brain biocompatibility of drug-releasing biodegradable microspheres by scanning and transmission electron microscopy J. Neurosurg. 95 2001 489 494
22. B. ArIca, H.S. Kaş, M.F. Sargon, and A.A. HIncal Physicochemical characteristics of levodopa chitosan microspheres for brain delivery AAPS Pharm. Sci. Suppl. 1 1998 S-32
23. M.D. Lindner, and D.F. Emerich Therapeutic potential of a polymer-encapsulated l-DOPA and dopamine-producing cell line in rodent and primate models of Parkinson's disease Cell Transplant 7 1998 165 174