Glutamine regulates amino acid transport and glutathione levels in a human neuroblastoma cell line

Pediatric Surgery International

Volumn 21, Issue 1, 2005, Pages 29-33

  Soh, Hideki ^a   Wasa, Masafumi ^a   Wang, Hong Sheng ^a   Fukuzawa, Masahiro ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Amino acid transport; Glutamine; Glutathione; Neuroblastoma

Indexed keywords

DNA; GLUTAMINE; GLUTATHIONE;

AMINO ACID TRANSPORT; ARTICLE; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; DNA SYNTHESIS; HUMAN; HUMAN CELL; NEUROBLASTOMA; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REGULATORY MECHANISM; TUMOR CELL CULTURE; TUMOR CELL LINE; TUMOR GROWTH;

AMINO ACIDS; BIOLOGICAL TRANSPORT, ACTIVE; CELL DIVISION; DNA, NEOPLASM; GLUTAMINE; GLUTATHIONE; HUMANS; NEUROBLASTOMA; TUMOR CELLS, CULTURED;

EID: 12844258831     PISSN: 01790358     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00383-004-1258-8     Document Type: Article

References (18)

1. Medina MA, Sanchez-Jimenez F, Marquez J, et al. (1992) Relevance of glutamine metabolism to tumor cell growth. Mol Cell Biochem 113:1-15
2. Fischer CP, Bode BP, Souba WW (1998) Adaptive alterations in cellular metabolism with malignant transformation. Ann Surg 227:627-636
3. Wasa M, Bode BP, Abcouwer SF, et al. (1996) Glutamine as a regulator of DNA and protein biosynthesis in human solid tumor cell lines. Ann Surg 224:189-197
4. Lusini L, Tripodi SA, Rossi R, et al. (2001) Altered glutathione anti-oxidant metabolism during tumor progression in human renal-cell carcinoma. Int J Cancer 91:55-59
5. Meister A (1991) Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharm Ther 51:155-194
6. Carretero J, Obrador E, Anasagasti MJ, et al. (1999) Growth-associated changes in glutathione content correlate with liver metastatic activity of B16 melanoma cells. Clin Exp Metastasis 17:567-574
7. Collins CL, Wasa M, Souba WW, et al. (1998) Determinations of glutamine dependence and utilization by normal and tumor-derived breast cell lines. J Cell Physiol 176:166-178
8. Abcouwer SF, Behrens E, Lustig RJ, et al. (1997) Stress responses to glutamine starvation in human breast cell lines. Proc. Am. Assoc. Cancer Res 38:543
9. Suarez A, Hartmann O, Vassal G, et al. (1991) Treatment of stage IV-S neuroblastoma: a study of 34 cases treated between 1982 and 1987. Med Ped Oncol 19:473-477
10. Gazzola GC, Dall'Asia V, Franchi-Gazzola R, et al. (1981) The cluster tray method for rapid measurement of solute fluxes in adherent cultured cells. Anal Biochem 115:368-374
11. Smith PK, Krohn RI, Hermanson GT, et al. (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85
12. Wasa M, Bode BP, Souba WW (1996) Adaptive regulation of amino acid transport in nutrient-deprived human hepatomas. Am J Surg 171:163-169
13. Low SY, Rennie MJ, Taylor PM (1994) Sodium-dependent glutamate transport in cultured rat myotubes after glutamine deprivation. FASEB J 8:127-131
14. Kilberg MS, Han HP, Barber EF, et al. (1985) Adaptive regulation of neutral amino acid transport system A in rat H4 hepatoma cells. J Cell Physiol 122:290-298
15. Wasa M, Wang HS, Tazuke Y, et al. (2001) Insulin-like growth factor-I stimulates amino acid transport in a glutamine-deprived human neuroblastoma cell line. Biochim Biophys Acta 1525:118-124
16. Obrador E, Navarro J, Mompo J, et al. (1997) Glutathione and the rate of cellular proliferation determine tumour cell sensitivity to tumour necrosis factor in vivo. Biochem J 325:183-189
17. Mickisch G, Fajta S, Bier H, et al. (1991) Cross-resistance patterns related to glutathione metabolism in primary human renal cell carcinoma. Urol Res 19:99-103
18. Shotwell MA, Kilberg MS, Oxender DL (1983) The regulation of neutral amino acid transport in mammalian cells. Biochim Biophys Acta 737:267-284