Effects of a short course of leflunomide on T-independent B-lymphocyte xenoreactivity and on susceptibility of xenografts to acute or chronic rejection

Transplantation

Volumn 79, Issue 2, 2005, Pages 135-141

  Yan, Yehong ^a   Verbeken, Eric ^a   Yu, Lisong ^a   Rutgeerts, Omer ^a   Goebels, Jozef ^a   Segers, Constant ^a   Lin, Yuan ^a   Waer, Mark ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Antigenicity; B cell xenotolerance; Chronic rejection; Leflunomide

Indexed keywords

IMMUNOGLOBULIN M ANTIBODY; LEFLUNOMIDE;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM; EX VIVO STUDY; GRAFT SURVIVAL; HAMSTER; HEART GRAFT; HEART TRANSPLANTATION; LYMPHOCYTE TRANSFER; MALE; MOUSE; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; RAT; RECIPIENT; SHORT COURSE THERAPY; TRANSPLANTATION TOLERANCE; TREATMENT WITHDRAWAL; VASCULAR LESION; XENOGRAFT; XENOTRANSPLANTATION;

ANIMALS; COMPLEMENT SYSTEM PROTEINS; CRICETINAE; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE AGENTS; ISOXAZOLES; MALE; MESOCRICETUS; MICE; MICE, INBRED C57BL; MICE, NUDE; TRANSPLANTATION, HETEROLOGOUS;

EID: 12744268535     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000147464.63188.4B     Document Type: Article

References (26)

1. Dorling A. Are anti-endothelial cell antibodies a pre-requisite for the acute vascular rejection of xenografts? Xenotransplantation 2003; 10: 16.
2. Lin Y, Vandeputte M, Waer M. Effect of leflunomide and cyclosporine on the occurrence of chronic xenograft lesions. Kidney Int 1995; 48: 52.
3. Platt JL. The immunological hurdles to cardiac xenotransplantation. J Card Surg 2001; 16: 439.
4. Ohdan H, Yang YG, Swenson KG, et al. T cell and B cell tolerance to Gal alpha 1,3Gal-expressing heart xenografts is achieved in alpha 1,3galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism. Transplantation 2001; 71: 1532.
5. Xia GL, Goebels J, Rutgeerts O, et al. Transplantation tolerance and autoimmunity after xenogeneic thymus transplantation. J Immunol 2001; 166: 1843.
6. Bach FH, Ferran C, Hechenleitner P, et al. Accommodation of vascularized xenografts: Expression of "protective genes" by donor endothelial cells in host Th2 cytokine environment. Nat Med 1997; 3: 196.
7. Wang N, Lee JM, Tobiasch E, et al. Induction of xenograft accommodation by modulation of elicited antibody responses 1 2. Transplantation 2002; 7: 334.
8. Geller RL, Rubinstein P, Platt JL. Variation of expression of porcine xenogeneic antigens. Transplantation 1994; 58: 272.
9. Tearle RG, Tange MJ, Zannettino ZL, et al. The alpha-1,3- galactosyltransferase knockout mouse: Implications for xenotransplantation. Transplantation 1996; 61: 13.
10. Waer M. The use of leflunomide in transplantation immunology. Transpl Immunol 1996; 4: 181.
11. Manna SK, Aggarwal BB. Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-κB activation and gene expression. J Immunol 1999; 162: 2095.
12. Manna SK, Mukhopadhyay A, Aggarwal BB. Leflunomide suppresses TNF-induced cellular responses: Effects on NF-kappaB, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. J Immunol 2000; 165: 5962.
13. Waldman WJ, Bickerstaff A, Gordillo G, et al. Inhibition of angiogenesis-related endothelial activity by the experimental immunosuppressive agent leflunomide. Transplantation 2001; 72: 1578.
14. Cutolo M, Sulli A, Ghiorzo P, et al. Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis. Ann Rheum Dis 2003; 62: 297.
15. Wahl LM, Smith PD. Isolation of monocyte/macrophage population. In: Coligan JE, Kruisbeek AM, Magrguliers DH, et al., eds. Current protocols in immunology, vol. 2. New York, Wiley 1994, p 7.6.1.
16. Lin Y, Goebeles J, Xia GL, et al. Induction of specific transplantation tolerance across xenogeneic barriers in the T-independent immune compartment. Nat Med 1998; 4: 173.
17. Lin Y, Vandeputte M, Waer M. Suppression of T-independent IgM xenoantibody formation by leflunomide during xenografting of hamster hearts in rats. Transplantation 1998; 65: 332.
18. Chong AS, Ma LL, Shen J, et al. Modification of humoral responses by the combination of leflunomide and cyclosporine in Lewis rats transplanted with hamster hearts. Transplantation 1997; 64: 1650.
19. Lin Y, Vandeputte M, Waer M. Natural killer cell- and macrophage-mediated rejection of concordant xenografts in the absence of T and B cell responses. J Immunol 1997; 158: 5658.
20. Xia GL, Ji P, Rutgeerts O, et al. Natural kill cell- and macrophage mediated discordant guinea pig-rat xenograft rejection in the absence of complement, xenoantibody and T cell immunity. Transplantation 2000; 70: 86.
21. Lin Y, Soares MP, Sato K, et al. Accommodated xenografts survive in the presence of anti-donor antibodies and complement that precipitate rejection of naive xenografts. J Immunol 1999; 163: 2850.
22. Parker W, Holzknecht ZE, Song A, et al. Fate of antigen in xenotransplantation, implication for acute vascular rejection and accommodation. Am J Pathol 1998; 152: 829.
23. Hauet T, Han Z, Wang Y, et al. Modulation of peripheral-type benzodiazepine receptor levels in a reperfusion injury pig kidney-graft model. Transplantation 2002; 74: 1507.
24. Neil Desley AH, Lynch SV, Hardie LR, et al. Cold storage preservation and warm ischemic injury to isolated arterial segments: Endothelial cell injury. Am J Transplant 2002; 2: 400.
25. Bach FH, Ferran C, Candinas D, et al. Accommodation of xenografts: Expression of "protective genes" in endothelial and smooth muscle cells. Transplant Proc 1997; 29: 56.
26. DeRoover A, Williams A, Hubscher S, et al. Donor pretreatment with leflunomide has an adverse effect on rat cardiac allograft survival. Transpl Immunol 1997; 5: 136.