n-3 Polyunsaturated fatty acids throughout the cancer trajectory: Influence on disease incidence, progression, response to therapy and cancer-associated cachexia

Nutrition Research Reviews

Volumn 17, Issue 2, 2004, Pages 177-192

  Baracos, Vickie E ^a   Mazurak, Vera C ^a   Ma, David W L ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Cachexia; Cancer; Chemotherapy; Drug resistance; Fish oil; Polyunsaturated fatty acids

Indexed keywords

ALKYLATING AGENT; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; BLEOMYCIN; CISPLATIN; CORN OIL; CYTARABINE; DOCOSAHEXAENOIC ACID; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; FISH OIL; GEMCITABINE; ICOSANOID; ICOSAPENTAENOIC ACID; IDARUBICIN; IRINOTECAN; MITOXANTRONE; NAVELBINE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PACLITAXEL; POLYUNSATURATED FATTY ACID; SAFFLOWER OIL;

ADVANCED CANCER; ALOPECIA; ANGIOGENESIS; ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; BLOATING; BONE MARROW TOXICITY; BREAST CANCER; CACHEXIA; CANCER CHEMOTHERAPY; CANCER PREVENTION; CANCER RISK; CANCER SURVIVAL; CARDIOTOXICITY; CAVEOLA; CONTROLLED STUDY; DIARRHEA; DIET SUPPLEMENTATION; DRUG CAPSULE; DRUG CYTOTOXICITY; FATTY ACID METABOLISM; FLOW CYTOMETRY; GASTROINTESTINAL TOXICITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LEUKEMIA; LIPID RAFT; LUNG SMALL CELL CANCER; LUNG TUMOR; LYMPHOMA; METASTASIS; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; TASTE DISORDER; WASTING SYNDROME;

ANIMALIA; CARTHAMUS TINCTORIUS; ZEA MAYS;

EID: 12744263128     PISSN: 09544224     EISSN: None     Source Type: Journal    
DOI: 10.1079/NRR200488     Document Type: Review

References (155)

1. Abulrob ANG, Mason M, Bryce R & Gumbleton M (2000) The effect of fatty acids and analogues upon intracellular levels of doxorubicin in cells displaying P-glycoprotein mediated multidrug resistance. Journal of Drug Targeting 8, 247-256.
2. Amano H, Hayashi I, Endo H, Kitasato H, Yamashina S, Maruyama T, Kobayashi M, Satoh K, Narita M, Sugimoto Y, Murata T, Yoshimura H, Narumiya S & Majima M (2003) Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. Journal of Experimental Medicine 197, 221-232.
3. Amiano P, Dorronsoro M, Larranaga N, Renobales M & Ruiz de Gordoa JC (2002) Very-long-chain omega-3 fatty acids as markers for habitual fish intake in Spain. IARC Scientific Publications 156, 201-202.
4. Arancia G, Molinari A, Calcabrini A, Meschini S & Cianfriglia M (2001) Intracellular P-glycoprotein in multidrug resistant tumor cells. Italian Journal of Anatomy and Embryology 106, 59-68.
5. Argiles JM, Alvarez B, Carbo N, Busquets S, van Royen M & Lopez-Soriano FJ (2000) The divergent effects of tumour necrosis factor-alpha on skeletal muscle: implications in wasting. European Cytokine Network 11, 552-559.
6. Argiles JM & Lopez-Soriano FJ (1999) The role of cytokines in cancer cachexia. Medical Research Reviews 19, 223-248.
7. Augustsson K, Michaud DS, Rimm EB, Leitzmann MF, Stampfer MJ, Willett WC & Giovannucci E (2003) A prospective study of intake of fish and marine fatty acids and prostate cancer. Cancer Epidemiology, Biomarkers and Prevention 12, 64-67.
8. Badawi AF & Badr MZ (2003) Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis. International Journal of Cancer 103, 84-90.
9. Baracos VE (2000) A panoply of anabolic and catabolic mediators. Current Opinion in Clinical Nutrition and Metabolic Care 3, 169-170.
10. Baracos VE (2001) A deadly combination of anorexia and hypermetabolism. Current Opinion in Clinical Nutrition and Metabolic Care 4, 175-177.
11. Barber MD, Fearon KC, Tisdale MJ, McMillan DC & Ross JA (2001) Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia. Nutrition and Cancer 40, 118-124.
12. Barber MD & Fearon KCH (2001) Tolerance and incorporation of a high-dose eicosapentaenoic acid diester emulsion by patients with pancreatic cancer cachexia. Lipids 36, 347-351.
13. Barber MD, Ross JA & Fearon KC (2000) Disordered metabolic response with cancer and its management. World Journal of Surgery 24, 681-689.
14. Barber MD, Ross JA, Preston T, Shenkin A & Fearon KC (1999a) Fish oil-enriched nutritional supplement attenuates progression of the acute-phase response in weight-losing patients with advanced pancreatic cancer. Journal of Nutrition 129, 1120-1125.
15. Barber MD, Ross JA, Voss AC, Tisdale MJ & Fearon KC (1999b) The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer. British Journal of Cancer 81, 80-86.
16. Bartsch H, Nair J & Owen RW (1999) Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis 20, 2209-2218.
17. Batist G, Tulpule A, Sinha BK, Katki AG, Myers CE & Cowan KH (1986) Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. Journal of Biological Chemistry 261, 15544-15549.
18. Birkenkamp-Demtroder K, Christensen LL, Olesen SH, Frederiksen CM, Laiho P, Aaltonen LA, Laurberg S, Sorensen FB, Hagemann R & Orntoft TF (2002) Gene expression in colorectal cancer. Cancer Research 62, 4352-4363.
19. Black HS, Thornby JI, Gerguis J & Lenger W (1992) Influence of dietary omega-6, -3 fatty acid sources on the initiation and promotion stages of photocarcinogenesis. Photochemistry and Photobiology 56, 195-199.
20. Bordoni A, Biagi PL & Hrelia S (1999) The impairment of essential fatty acid metabolism as a key factor in doxorubicin-induced damage in cultured rat cardiomyocytes. Biochimica et Biophysica Acta 1440, 100-106.
21. Bougnoux P (1999) n-3 Polyunsaturated fatty acids and cancer. Current Opinion in Clinical Nutrition and Metabolic Care 2, 121-126.
22. Bradley MO, Webb NL, Anthony FH, Devanesan P, Witman PA, Hemamalini S, Chander MC, Baker SD, He LF, Horwitz SB & Swindell CS (2001) Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel. Clinical Cancer Research 7, 3229-3238.
23. Bruera E, Strasser F, Palmer JL, Willey J, Calder K, Amyotte G & Baracos VE (2003) Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a double blind, placebo-controlled trial. Journal of Clinical Oncology 21, 129-134.
24. Burns CP, Halabi S, Clamon GH, Hars V, Wagner BA, Hohl RJ, Lester E, Kirshner JJ, Vinciguerra V & Paskett E (1999) Phase I clinical study of fish oil fatty acid capsules for patients with cancer cachexia: cancer and leukemia group B study 9473. Clinical Cancer Research 5, 3942-3947.
25. Cabal-Manzano R, Bhargava P, Torres-Duarte A, Marshall J, Bhargava P & Wainer IW (2001) Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss. British Journal of Cancer 84, 1599-1601.
26. Cahlin C, Gelin J, Delbro D, Lonnroth C, Doi C & Lundholm K (2000) Effect of cyclooxygenase and nitric oxide synthase inhibitors on tumor growth in mouse tumor models with and without cancer cachexia related to prostanoids. Cancer Research 60, 1742-1749.
27. Calder PC (2003) Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients. Brazilian Journal of Medical and Biological Research 36, 433-446.
28. Cariuk P, Lorite MJ, Todorov PT, Field WN, Wigmore SJ & Tisdale MJ (1997) Induction of cachexia in mice by a product isolated from the urine of cachectic cancer patients. British Journal of Cancer 76, 606-613.
29. Cha MC, Meckling KA & Stewart C (2002) Dietary docosahexaenoic acid levels influence the outcome of arabinosylcytosine chemotherapy in L1210 leukemic mice. Nutrition and Cancer 44, 176-181.
30. Cha SH, Fukushima A, Sakuma K & Kagawa Y (2001) Chronic docosahexaenoic acid intake enhances expression of the gene for uncoupling protein 3 and affects pleiotropic mRNA levels in skeletal muscle of aged C57BL/6NJc1 mice. Journal of Nutrition 131, 2636-2642.
31. Chajes V & Bougnoux P (2003) Omega-6/omega-3 polyunsaturated fatty acid ratio and cancer. World Reviews of Nutrition and Dietetics 92, 133-151.
32. Chen ZY & Istfan NW (2000) Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. Prostaglandins Leukotrienes and Essential Fatty Acids 63, 301-308.
33. Chen ZY & Istfan NW (2001) Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin dependent kinases and S-phase entry by serum stimulation in HT-29 cells. Prostaglandins Leukotrienes and Essential Fatty Acids 64, 67-73.
34. Chung BH, Mitchell SH, Zhang JS & Young CY (2001) Effects of docosahexaenoic acid and eicosapentaenoic acid on androgen-mediated cell growth and gene expression in LNCaP prostate cancer cells. Carcinogenesis 22, 1201-1206.
35. Clarke RG, Lund EK, Latham P, Finder AC & Johnson IT (1999) Effect of eicosapentaenoic acid on the proliferation and incidence of apoptosis in the colorectal cell line HT29. Lipids 34, 1287-1295.
36. Clemens MR, Waladkhani AR, Bublitz K, Ehninger G & Gey KF (1997) Supplementation with antioxidants prior to bone marrow transplantation. Wiener Klinische Wochenschrift 109, 771-776.
37. Cognault S, Jourdan ML, Germain E, Pitavy R, Morel E, Durand G, Bougnoux P & Lhuillery C (2000) Effect of an alpha-linolenic acid-rich diet on rat mammary tumor growth depends on the dietary oxidative status. Nutrition and Cancer 36, 33-41.
38. Cohen LA (2000) Re: Meta-analysis: dietary fat intake, serum estrogen levels, and the risk of breast cancer. Journal of the National Cancer Institute 92, 78.
39. Collett ED, Davidson LA, Fan YY, Lupton JR & Chapkin RS (2001) n-6 and n-3 Polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. American Journal of Physiology 280, C1066-C1075.
40. Conklin KA (2002) Dietary polyunsaturated fatty acids: impact on cancer chemotherapy and radiation. Alternative Medicine Reviews 7, 4-21.
41. Connolly JM, Gilhooly EM & Rose DP (1999) Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer cell growth and apoptosis in nude mice. Nutrition and Cancer 35, 44-49.
42. Cowan KH, Batist G, Tulpule A, Sinha BK & Myers CE (1986) Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats. Proceedings of the National Academy of Sciences USA 83, 9328-9332.
43. Das UN, Madhavi N, Sravan KG, Padma M & Sangeetha P (1998) Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites? Prostaglandins Leukotrienes and Essential Fatty Acids 58, 39-54.
44. Das UN, Ramos EG & Meguid MM (2003) Metabolic alterations during inflammation and its modulation by central actions of omega-3 fatty acids. Current Opinion in Clinical Nutrition and Metabolic Care 6, 413-419.
45. Davidson LA, Lupton JR, Jiang YH & Chapkin RS (1999) Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics. Carcinogenesis 20, 785-791.
46. Davies CL, Loizidou M, Cooper AJ & Taylor I (1999) Effect of gamma-linolenic acid on cellular uptake of structurally related anthracyclines in human drug sensitive and multidrug resistant bladder and breast cancer cell lines. European Journal of Cancer 35, 1534-1540.
47. de Deckere EA (1999) Possible beneficial effect of fish and fish n-3 polyunsaturated fatty acids in breast and colorectal cancer. European Journal of Cancer Prevention 8, 213-221.
48. Dennis LK, Snetselaar LG, Nothwehr FK & Stewart RE (2003) Developing a scoring method for evaluating dietary methodology in reviews of epidemiologic studies. Journal of the American Dietetic Association 103, 483-487.
49. Fan YY, McMurray DN, Ly LH & Chapkin RS (2003) Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid rafts. Journal of Nutrition 133, 1913-1920.
50. Fearon KC, von Meyenfeldt MF, Moses AG, Van Geenen R, Roy A, Gouma DJ, Giacosa A, van Gossum A, Bauer J, Barber MD, Aaronson NK, Voss AC & Tisdale MJ (2003) Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial. Gut 52, 1479-1486.
51. Furukawa K, Yamamori H, Takagi K, Hayashi N, Suzuki R, Nakajima N & Tashiro T (2002) Influences of soybean oil emulsion on stress response and cell-mediated immune function in moderately or severely stressed patients. Nutrition 18, 235-240.
52. Germain E, Chajes V, Cognault S, Lhuillery C & Bougnoux P (1998) Enhancement of doxorubicin cytotoxicity by polyunsaturated fatty acids in the human breast tumor cell line MDA-MB-231: relationship to lipid peroxidation. International Journal of Cancer 75, 578-583.
53. Germain E, Lavandier F, Chajes V, Schubnel V, Bonnet P, Lhuillery C & Bougnoux P (1999) Dietary n-3 polyunsaturated fatty acids and oxidants increase rat mammary tumor sensitivity to epirubicin without change in cardiac toxicity. Lipids 34, Suppl., S203.
54. Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC & Kalfarentzos F (1998) Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy. Cancer 82, 395-402.
55. Goldstein LJ, Pastan I & Gottesman MM (1992) Multidrug resistance in human cancer. Critical Reviews in Oncology and Hematology 12, 243-253.
56. Gottesman MM & Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annual Reviews of Biochemistry 62, 385-427.
57. Griffini P, Fehres O, Klieverik L, Vogels IM, Tigchelaar W, Smorenburg SM & Van Noorden CJ (1998) Dietary omega-3 polyunsaturated fatty acids promote colon carcinoma metastasis in rat liver. Cancer Research 58, 3312-3319.
58. Hardman WE (2002) Omega-3 fatty acids to augment cancer therapy. Journal of Nutrition 132, 3508S-3512S.
59. Hardman WE, Avula CP, Fernandes G & Cameron IL (2001) Three percent dietary fish oil concentrate increased efficacy of doxorubicin against MDA-MB 231 breast cancer xenografts. Clinical Cancer Research 7, 2041-2049.
60. Hardman WE, Moyer MP & Cameron IL (1999) Fish oil supplementation enhanced CPT-11 (irinotecan) efficacy against MCF7 breast carcinoma xenografts and ameliorated intestinal side-effects. British Journal of Cancer 81, 440-448.
61. Hardman WE, Moyer MP & Cameron IL (2000) Dietary fish oil sensitizes A549 lung xenografts to doxorubicin chemotherapy. Cancer Letters 151, 145-151.
62. Hardman WE, Munoz J Jr & Cameron IL (2002) Role of lipid peroxidation and antioxidant enzymes in omega 3 fatty acids induced suppression of breast cancer xenograft growth in mice. Cancer Cell International 2, 10.
63. Hong MY, Chapkin RS, Barhoumi R, Burghardt RC, Turner ND, Henderson CE, Sanders LM, Fan YY, Davidson LA, Murphy ME, Spinka CM, Carroll RJ & Lupton JR (2002) Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes. Carcinogenesis 23, 1919-1925.
64. Hong MY, Chapkin RS, Davidson LA, Turner ND, Morris JS, Carroll RJ & Lupton JR (2003) Fish oil enhances targeted apoptosis during colon tumor initiation in part by downregulating Bcl-2. Nutrition and Cancer 46, 44-51.
65. Hrelia S, Bordoni A, Angeloni C, Leoncini E, Galina Toschi T, Lercker G & Biagi PL (2002) Green tea extracts can counteract the modification of fatty acid composition induced by doxorubicin in cultured cardiomyocytes. Prostaglandins Leukotrienes and Essential Fatty Acids 66, 519-524.
66. Hughes-Fulford M, Chen Y & Tjandrawinata RR (2001) Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells. Carcinogenesis 22, 701-707.
67. Islam-Ali B, Khan S, Price SA & Tisdale MJ (2001) Modulation of adipocyte G-protein expression in cancer cachexia by a lipid-mobilizing factor (LMF). British Journal of Cancer 85, 758-763.
68. Iwamoto S, Senzaki H, Kiyozuka Y, Ogura E, Takada H, Hioki K & Tsubura A (1998) Effects of fatty acids on liver metastasis of ACL-15 rat colon cancer cells. Nutrition and Cancer 31, 143-150.
69. Jatoi A, Rowland M, Loprinzi CL, Sloan JA, Dakhil SR, MacDonald N, Gagnon B, Novotny PJ, Malliard JA & Krook JE (2003) An eicosapentaenoic acid (EPA)-enriched supplement versus megestrol acetate (MA) versus both for patients with cancer-associated wasting. A collaborative effort from the North Central Cancer Treatment Group (NCCTG) and the National Cancer Institute of Canada (NCIC). American Society of Clinical Oncology 22, 743.
70. Jho DH, Babcock TA, Tevar R, Helton WS & Espat NJ (2002) Eicosapentaenoic acid supplementation reduces tumor volume and attenuates cachexia in a rat model of progressive non-metastasizing malignancy. Journal of Parenteral and Enteral Nutrition 26, 291-297.
71. Jiang WG, Bryce RP & Horrobin DF (1998) Essential fatty acids: molecular and cellular basis of their anti-cancer action and clinical implications. Critical Reviews Oncology/Hematology 27, 179-209.
72. Klein V, Chajes V, Germain E, Schulgen G, Pinault M, Malvy D, Lefrancq T, Pignon A, Le Floch O, Lhuillery C & Bougnoux P (2000) Low alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer. European Journal of Cancer 36, 335-340.
73. Kotler DP (2000) Cachexia. Annals of Internal Medicine 133, 622-634.
74. Kris-Etherton PM, Harris WS & Appel LJ (2002) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106, 2747-2757.
75. Kumar GS & Das UN (1995) Free radical-dependent suppression of growth of mouse myeloma cells by alpha-linolenic and eicosapentaenoic acids in vitro. Cancer Letters 92, 27-38.
76. Laviano A, Meguid MM & Rossi-Fanelli F (2003) Cancer anorexia: clinical implications, pathogenesis, and therapeutic strategies. Lancet Oncology 4, 686-694.
77. Lavie Y, Fiucci G, Czarny M & Liscovitch M (1999) Changes in membrane micordomains and caveolae constituents in multidrug-resistant cancer cells. Lipids 34, Suppl., S57-S63.
78. Lavie Y & Liscovitch M (2000) Changes in lipid and protein constituents of rafts and caveolae in multidrug resistant cancer cells and their functional consequences. Glycoconjugate Journal 17, 253-259.
79. Liu G, Bibus DM, Bode AM, Ma WY, Holman RT & Dong Z (2001) Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells. Proceedings of the National Academy of Sciences USA 98, 7510-7515.
80. Liu P, Rudick M & Anderson RGW (2002) Multiple functions of caveolin-1. Journal of Biological Chemistry 277, 41295-41298.
81. Liu QY & Tan BK (2000) Effects of cis-unsaturated fatty acids on doxorubicin sensitivity in P388/DOX resistant and P388 parental cell lines. Life Sciences 67, 1207-1218.
82. Lorite MJ, Smith HJ, Arnold JA, Morris A, Thompson MG & Tisdale MJ (2001) Activation of ATP-ubiquitin-dependent proteolysis in skeletal muscle in vivo and murine myoblasts in vitro by a proteolysis-inducing factor (PIF). British Journal of Cancer 85, 297-302.
83. Lorite MJ, Thompson MG, Drake JL, Carling G & Tisdale MJ (1998) Mechanism of muscle protein degradation induced by a cancer cachectic factor. British Journal of Cancer 78, 850-856.
84. MacDonald N, Easson AM, Mazurak VC, Dunn GP & Baracos VE (2003) Understanding and managing cancer cachexia. Journal of the American College of Surgeons 197, 143-161.
85. McEntee MF & Whelan J (2002) Dietary polyunsaturated fatty acids and colorectal neoplasia. Biomedical Pharmacotherapy 56, 380-387.
86. Mariadason JM, Arango D, Corner GA, Aranes MJ, Hotchkiss KA, Yang W & Augenlicht LH (2002) A gene expression profile that defines colon cell maturation in vitro. Cancer Research 62, 4804.
87. Marra CA, de Alaniz MJ & Brenner RR (1986) Modulation of delta 6 and delta 5 rat liver microsomal desaturase activities by dexamethasone-induced factor. Biochimica et Biophysica Acta 879, 388-393.
88. Meguid MM, Fetissov SO, Varma M, Sato T, Zhang L, Laviano A & Rossi-Fanelli F (2000) Hypothalamic dopamine and serotonin in the regulation of food intake. Nutrition 16, 843-857.
89. Menendez JA, del Mar B, Montera S, Sevilla E, Escrich E, Solanas M, Cortes-Funes H & Colomer R (2001) Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells. European Journal of Cancer 37, 402-413.
90. Mirnikjoo B, Brown SE, Chang WC, Morris JS, Wang N, Carroll RJ, Turner ND, Lupton JR & Chapkin RS (2001) Protein kinase inhibition by omega-3 fatty acids. Journal of Biological Chemistry 276, 10888-10896.
91. Nair SS, Leitch J & Garg ML (2001) n-3 Polyunsaturated fatty acid supplementation alters inositol phosphate metabolism and protein kinase C activity in adult porcine cardiac myocytes. Journal of Nutritional Biochemistry 12, 7-13.
92. Nakamura S & Nishizuka Y (1994) Lipid mediators and protein kinase C activation for the intracellular signaling network. Journal of Biochemistry 115, 1029-1034.
93. Narayanan BA, Narayanan NK & Reddy BS (2001) Docosahexaenoic acid regulated genes and transcription factors inducing apoptosis in human colon cancer cells. International Journal of Oncology 19, 1255-1262.
94. Narayanan BA, Narayanan NK, Simi B & Reddy BS (2003) Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. Cancer Research 63, 972-979.
95. Ogilvie GK, Fettman MJ, Mallinckrodt CH, Walton JA, Hansen RA, Davenport DJ, Gross KL, Richardson KL, Rogers Q & Hand MS (2000) Effect of fish oil, arginine, and doxorubicin chemotherapy on remission and survival time for dogs with lymphoma: a double-blind, randomized placebo-controlled study. Cancer 88, 1916-1928.
96. Palakurthi SS, Fluckiger R, Aktas H, Changolkar AK, Shahsafaei A, Harneit S, Kilic E & Halperin JA (2000) Inhibition of translation initiation mediates the anticancer effect of the n-3 polyunsaturated fatty acid eicosapentaenoic acid. Cancer Research 60, 2919-2925.
97. Pandian SS, Sneddon AA, Bestwick CS, McClinton S, Grant I, Wahle KW & Heys SD (2001) Fatty acid regulation of protein kinase C isoforms in prostate cancer cells. Biochemical and Biophysical Research Communications 283, 806-812.
98. Pasqualini ME, Heyd VL, Manzo P & Eynard AR (2003) Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential. Prostaglandins Leukotrienes and Essential Fatty Acids 68, 9-16.
99. Pike LJ (2003) Lipid rafts: bringing order to chaos. Journal of Lipid Research 44, 655-667.
100. Pike LJ, Han X, Chung K-N & Gross RW (2002) Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis. Biochemistry 41, 2075-2088.
101. Pratt VC, Watanabe S, Bruera E, Mackey J, Clandinin MT, Baracos VE & Field CJ (2002) Plasma and neutrophil fatty acid composition in advanced cancer patients and response to fish oil supplementation. British Journal of Cancer 87, 1370-1378.
102. Ravagnan L, Roumier T & Kroemer G (2002) Mitochondria, the killer organelles and their weapons. Journal of Cellular Physiology 192, 131-137.
103. Rhodes DR, Barrette TR, Rubin MA, Ghosh D & Chinnaiyan AM (2002) Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer. Cancer Research 62, 4427-4433.
104. Robinson LE, Clandinin MT & Field CJ (2001) R3230AC rat mammary tumor and dietary long-chain (n-3) fatty acids change immune cell composition and function during mitogen activation. Journal of Nutrition 131, 2021-2027.
105. Rose DP & Connolly JM (1993) Effects of dietary omega-3 fatty acids on human breast cancer growth and metastases in nude mice. Journal of the National Cancer Institute 85, 1743-1747.
106. Rose DP & Connolly JM (1999a) Antiangiogenicity of docosahexaenoic acid and its role in the suppression of breast cancer cell growth in nude mice. International Journal of Oncology 15, 1011-1015.
107. Rose DP & Connolly JM (1999b) Omega-3 fatty acids as cancer chemopreventive agents. Pharmacology and Therapeutics 83, 217-244.
108. Rose DP & Connolly JM (2000) Regulation of tumor angiogenesis by dietary fatty acids and eicosanoids. Nutrition and Cancer 37, 119-127.
109. Ross JA & Fearon KC (2002) Eicosanoid-dependent cancer cachexia and wasting. Current Opinion in Clinical Nutrition and Metabolic Care 5, 241-248.
110. Rudra PK & Krokan HE (2001) Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid. Anticancer Research 21, 29-38.
111. Sasaki T, Kobayashi Y, Shimizu J, Wada M, In'nami S, Kanke Y & Takita T (1998) Effects of dietary n-3-to-n-6 polyunsaturated fatty acid ratio on mammary carcinogenesis in rats. Nutrition and Cancer 30, 137-143.
112. Sauer LA, Dauchy RT & Blask DE (2000) Mechanism for the antitumor and anticachectic effects of n-3 fatty acids. Cancer Research 60, 5289-5295.
113. Senchenkov A, Litvak DA & Cabot MC (2001) Targeting ceramide metabolism - a strategy for overcoming drug resistance. Journal of the National Cancer Institute 93, 347-357.
114. Senzaki H, Iwamoto S, Ogura E, Kiyozuka Y, Arita S, Kurebayashi J, Takada H, Hioki K & Tsubura A (1998) Dietary effects of fatty acids on growth and metastasis of KPL-1 human breast cancer cells in vivo and in vitro. Anticancer Research 18, 1621-1627.
115. Shappell SB, Olson SJ, Hannah SE, Manning S, Roberts RL, Masumori N, Jisaka M, Boeglin WE, Vader V, Dave DS, Shook MF, Thomas TZ, Funk CD, Brash AR & Matusik RJ (2003) Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma. Cancer Research 63, 2256-2267.
116. Siddiqui RA, Jenski LJ, Neff K, Harvey K, Kovacs RJ & Stillwell W (2001) Docosahexaenoic acid induces apoptosis in Jurkat cells by a protein phosphatase-mediated process. Biochimica et Biophysica Acta 1499, 265-275.
117. Sidorenko I, Frantsiiants EM, Tkacheva EM, Musienko NV & Kartashov SZ (1998) The effect of chemotherapeutic drugs on free-radical oxidation of lipids in the lymph of lung cancer patients (in Russian). Voprosy Onkologii 44, 297-299.
118. Siegfried JM, Burke TG & Tritton TR (1985) Cellular transport of anthracyclines by passive diffusion. Implications for drug resistance. Biochemistry and Pharmacology 34, 593-598.
119. Sikic BI (1997) Pharmacologic approaches to reversing multidrug resistance. Seminars in Hematology 34, 40-47.
120. Simonsen N, van't Veer P, Strain JJ, Martin-Moreno JM, Huttunen JK, Navajas JF, Martin BC, Thamm M, Kardinaal AF, Kok FJ & Kohlmeier L (1998) Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC study. European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Breast Cancer. American Journal of Epidemiology 147, 342-352.
121. Simopoulos AP (1999) Evolutionary aspects of omega-3 fatty acids in the food supply. Prostaglandins Leukotrienes and Essential Fatty Acids 60, 421-429.
122. Simopoulos AP (2002) Omega-3 fatty acids in inflammation and autoimmune diseases. Journal of the American College of Nutrition 21, 495-505.
123. Smith HJ, Lorite MJ & Tisdale MJ (1999) Effect of a cancer cachectic factor on protein synthesis/degradation in murine C2C12 myoblasts: modulation by eicosapentaenoic acid. Cancer Research 59, 5507-5513.
124. Smith HJ & Tisdale MJ (2003) Induction of apoptosis by a cachectic-factor in murine myotubes and inhibition by eicosapentaenoic acid. Apoptosis 8, 161-169.
125. Spector AA & Burns CP (1987) Biological and therapeutic potential of membrane lipid modification in tumors. Cancer Research 47, 4529-4537.
126. Stoll BA (2001) n-3 Fatty acids and lipid peroxidation in breast cancer inhibition. British Journal of Nutrition 87, 193-198.
127. Stulnig TM, Berger M, Sigmund T, Raederstorff D, Stockinger H & Waldhausl W (1998) Polyunsaturated fatty acids inhibit T cell signal transduction by modification of detergent-insoluble membrane domains. Journal of Cell Biology 143, 637-644.
128. Stulnig TM, Huber J, Leitinger N, Imre E-M, Angelisova P, Nowotny P & Waldhausl W (2001) Polyunsaturated eicosapentaenoic acid displaces proteins from membrane rafts by altering raft lipid composition. Journal of Biological Chemistry 276, 37335-37340.
129. Swinnen JV, Van Veldhoven PP, Timmermans L, De Schrijver E, Brusselmans K, Vanderhoydonc F, Van de Sande T, Heemers H, Heyns W & Verhoeven G (2003) Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. Biochemical and Biophysical Research Communications 21, 898-903.
130. Takahata K, Tada M, Yazawa K & Tamaki T (1999) Protection from chemotherapy-induced alopecia by docosahexaenoic acid. Lipids 34, Suppl., S105.
131. Temple NJ (2002) Nutrition and disease: challenges of research design. Nutrition 18, 343-347.
132. Terry PD, Rohan TE & Wolk A (2003) Intakes of fish and marine fatty acids and the risks of cancers of the breast and prostate and of other hormone-related cancers: a review of the epidemiologic evidence. American Journal of Clinical Nutrition 77, 532-543.
133. Theile A & Kemper P (1998) Bleomycin-induced pulmonary fibrosis following chemotherapy of ovarian granulosa cell tumor (in German). Pneumologie 52, 325-332.
134. Thoennes SR, Tate PL, Price TM & Kilgore MW (2000) Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells. Molecular and Cellular Endocrinology 160, 67-73.
135. Tisdale MJ (2001) Loss of skeletal muscle in cancer: biochemical mechanisms. Frontiers in Bioscience 6, D164-D174.
136. Tisdale MJ (2003) The 'cancer cachectic factor'. Supportive Care in Cancer 11, 73-78.
137. Todorov PT, Field WN & Tisdale MJ (1999) Role of a proteolysis-inducing factor (PIF) in cachexia induced by a human melanoma (G361). British Journal of Cancer 80, 1734-1737.
138. Tsuji M, Murota S & Morita I (2003) Docosapentaenoic acid (22:5, n-3) suppressed tube-forming activity in endothelial cells induced by vascular endothelial growth factor. Prostaglandins Leukotrienes and Essential Fatty Acids 68, 337-342.
139. Verstovsek G, Byrd A, Frey MR, Petrelli NJ & Black JD (1998) Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes. Gastroenterology 115, 75-85.
140. Wahle KWJ & Heys SD (2002) Cell signal mechanisms, conjugated linoleic acids (CLAs) and anti-tumorigenesis. Prostaglandins Leukotrienes and Essential Fatty Acids 67, 183-186.
141. Wang H, Storlien LH & Huang XF (2002) Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression. American Journal of Physiology 282, E1352-E1359.
142. Weisburger JH (2000) Prevention of cancer and other chronic diseases worldwide based on sound mechanisms. Biofactors 12, 73-81.
143. Whelan J, Petrik MB, McEntee MF & Obukowicz MG (2002) Dietary EPA reduces tumor load in ApcMin/+ mice by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma- and alpha-linolenic acids have no effect. Advances in Experimental Medicine and Biology 507, 579-584.
144. Whitehouse AS, Smith HJ, Drake JL & Tisdale MJ (2001) Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid. Cancer Research 61, 3604-3609.
145. Whitehouse AS & Tisdale MJ (2001) Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation. Biochemical and Biophysical Research Communications 285, 598-602.
146. Wigmore SJ, Barber MD, Ross JA, Tisdale MJ & Fearon KC (2000) Effect of oral eicosapentaenoic acid on weight loss in patients with pancreatic cancer. Nutrition and Cancer 36, 177-184.
147. Wigmore SJ, McMahon AJ, Sturgeon CM & Fearon KC (2001) Acute-phase protein response, survival and tumour recurrence in patients with colorectal cancer. British Journal of Surgery 88, 255-260.
148. Woods JM, Mogollon A, Amin MA, Martinez RJ & Koch AE (2003) The role of COX-2 in angiogenesis and rheumatoid arthritis. Experimental and Molecular Pathology 74, 282-290.
149. Woutersen RA, Appel MJ, Garderen-Hoetmer A & Wijnands MV (1999) Dietary fat and carcinogenesis. Mutation Research 443, 111-127.
150. Yam D, Peled A & Shinitzky M (2001) Suppression of tumor growth and metastasis by dietary fish oil combined with vitamins E and C and cisplatin. Cancer Chemotherapy and Pharmacology 47, 34-40.
151. Yamamoto D, Kiyozuka Y, Adachi Y, Takada H, Hioki K & Tsubura A (1999) Synergistic action of apoptosis induced by eicosapentaenoic acid and TNP-470 on human breast cancer cells. Breast Cancer Research and Treatment 55, 149-160.
152. Yamauchi T, Watanabe M, Hasegawa H, Nishibori H, Ishii Y, Tatematsu H, Yamamoto K, Kubota T & Kitajima M (2003) The potential for a selective cyclooxygenase-2 inhibitor in the prevention of liver metastasis in human colorectal cancer. Anticancer Research 23, 245-249.
153. Zock PL (2001) Dietary fats and cancer. Current Opinion in Lipidology 12, 5-10.
154. Zuijdgeest-van Leeuwen SD, van der Heijden MS, Rietveld T, van den Berg JWO, Tilanus HW, Burgers JA, Paul Wilson JH & Dagnelie PC (2002) Fatty acid composition of plasma lipids in patients with pancreatic, lung and oesophageal cancer in comparison with healthy subjects. Clinical Nutrition 21, 225-230.
155. Zweifel BS, Davis TW, Ornberg RL & Masferrer JL (2002) Direct evidence for a role of cyclooxygenase 2-derived prostaglandin E2 in human head and neck xenograft tumors. Cancer Research 62, 6706-6711.