Intranasal absorption of rizatriptan - in vivo pharmacokinetics and bioavailability study in humans

Pharmazie

Volumn 60, Issue 1, 2005, Pages 39-41

  Chen, J ^a   Jiang, Xinguo G ^a   Jiang, W M ^a   Gao, X L ^a   Mei, N ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

RIZATRIPTAN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG TOLERABILITY; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ADULT; AEROSOLS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BLOOD PRESSURE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; HEART RATE; HUMANS; MALE; NASAL MUCOSA; SEROTONIN AGONISTS; SPECTROMETRY, FLUORESCENCE; TABLETS; TRIAZOLES; TRYPTAMINES;

EID: 12744261515     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Chen J, Jiang XG, Jiang WM, Nei N, Gao XL, Zhang QZ (2004) Liquid chromatographic method for the determination of rizatriptan in human plasma. J Chromatogr B 805: 169-173.
2. Cornaz AL, Buri P (1994) Nasal mucosa as an absorption barrier. Eur J Pharm Biopharm 40: 261-270.
3. De-Hoon JN, Willigers JM, Troost J, Struijker-boudier UA, Van Bortel LM (2000) Vascular effects of 5-HT1B/1D-receptor agonists in patients with migraine headaches. Clin Pharmacol Ther 68: 418-426.
4. Goldstein J, Ryan R, Jiang K, Getson A, Norman B, Block GA, Lines C (1998) The rizatriptan protocol 046 study group crossover comparison of rizatriptan 5 mg and 10 mg versus sumatriptan 25 mg and 50 mg in migraine. Headache 38: 737-747.
5. Hussain AA (1998) Intranasal drug delivery. Adv Drug Deliver Rev 29: 39-49.
6. Lee Y, Conroy JA, Stepanavage ME, Mendel CM, Somers G, McLoughlin DA, Olah TV, De-Smet M, Keymeulen B, Rogers JD (1999) Pharmacokinetics and tolerability of oral rizatriptan in healthy male and female volunteers. Br J Clin Pharmacol 47: 373-378.
7. Tokola RA, Neuvonen PJ (1984a) Effect of migraine attacks on paracetamol absorption. Br J Clin Pharmacol 18: 867-871.
8. Tokola RA, Neuvonen PJ (1984b) Effects of migraine attacks and metoclopramide on the absorption of tolfenamic acid. Br J Clin Pharmacol 17: 67-75.
9. Volans GN (1978) Migraine and drug absorption. Clin Pharmacokinet 3: 313-318.
10. Vyas KP, Halpin RA, Geer LA, Ellis JD, Liu LD, Cheng HY, Chavez-Eng C, Matuszewski BK, Varga SL, Guiblin AR, Rogers JD (2000) Disposition and pharmacokinetics of the antimigraine drug, rizatriptan, in human. Drug Metab Dispos 28: 89-95.