Does the reduction in systolic blood pressure alone explain the regression of left ventricular hypertrophy?

Journal of Human Hypertension

Volumn 18, Issue , 2004, Pages S23-S28

  Verdecchia, P ^a   Angeli, F ^a   Gattobigio, R ^b   Guerrieri, M ^c   Benemio, G ^b   Porcellati, C ^a  

^a Ospedale Silvestrini   (Italy)

^b AUSL 2 dell'Umbria   (Italy)

^c Divisione di Medicina Generale   (Italy)

Author keywords

Ambulatory blood pressure; Arterial hypertension; Echocardiography; Hypertrophy; Systolic blood pressure

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AMBULATORY MONITORING; ARTICLE; BLOOD PRESSURE MONITORING; BLOOD PRESSURE REGULATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DRUG RESPONSE; ECHOCARDIOGRAPHY; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HUMAN; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PULSE PRESSURE; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION; TRIACYLGLYCEROL BLOOD LEVEL;

ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; LINEAR MODELS; MALE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 12744255168     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/sj.jhh.1001797     Document Type: Article

References (22)

1. Levy D et al. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990; 322: 1561–1566.
2. Devereux RB, Roman MJ. Hypertensive cardiac hypertrophy: pathophysiologic and clinical characteristics. In: Laragh JH and Brenner BM (eds). Hypertension: Pathophysiology, Diagnosis and Management, 2nd edn. Raven Press, Ltd: New York, 1995, pp 409–424.
3. Verdecchia P et al. Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension. Circulation 1990; 81: 528–536.
4. Nichols WW, O’Rourke MF. Atherosclerosis. In: Arnold E (ed). McDonald’s Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. London, 1998, pp 396–401, Chapter 18.
5. Pannier B et al. Pulse pressure and echocardiographic findings in essential hypertension. J Hypertens 1989; 7: 127–132.
6. Baguet JP et al. Relationships between cardiovascular remodelling and the pulse pressure in never treated hypertension. J Hum Hypertens 2000; 14: 23–30.
7. Mourad JJ et al. Effect of hypertension on cardiac mass and radial artery wall thickness. Am J Cardiol 2000; 86: 564–567.
8. Verdecchia P et al. Prevalent influence of systolic over pulse pressure on left ventricular mass in essential hypertension. Eur Heart J 2002; 23: 658–665.
9. Mancia G et al. Ambulatory blood pressure is superior to clinic blood pressure in predicting treatmentinduced regression of left ventricular hypertrophy. SAMPLE Study Group. Study on Ambulatory Monitoring of Blood Pressure and Lisinopril Evaluation. Circulation 1997; 95: 1464–1470.
10. Verdecchia P et al. Long-term effects of losartan and enalapril, alone or with a diuretic, on ambulatory blood pressure and cardiac performance in hypertension: a case–control study. Blood Press Monit 2000; 5: 187–193.
11. Verdecchia P et al. Ambulatory blood pressure: an independent predictor of prognosis in essential hypertension. Hypertension 1994; 24: 793–801.
12. Verdecchia P et al. Prognostic significance of serial changes in left ventricular mass in essential hypertension. Circulation 1998; 97: 48–54.
13. Verdecchia P et al. Quantitative assessment of day-today spontaneous variability in non-invasive ambulatory blood pressure measurements in essential hypertension. J Hypertens 1991; 9(Suppl 6): S322–S323.
14. Devereux RB et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986; 57: 450–458.
15. Verdecchia P et al. Improved cardiovascular risk stratification by a simple ECG index in hypertension. Am J Hypertens 2003; 16: 646–652.
16. Grossman W, Jones D, McLaurin LP. Wall stress and patterns of hypertrpophy in the human left ventricle. J Clin Invest 1975; 56: 56–64.
17. Ganau A et al. Relation of left ventricular hemodynamic load and contractile performance to left ventricular mass in hypertension. Circulation 1990; 81: 25–36.
18. de Simone G, Pasanisi F, Contaldo F. Link of nonhemodynamic factors to hemodynamic determinants of left ventricular hypertrophy. Hypertension 2001; 38: 13–18.
19. Verdecchia P et al. Circulating insulin and insulin growth factor-1 are independent determinants of left ventricular mass and geometry in essential hypertension. Circulation 1999; 100: 1802–1807.
20. Verdecchia P. Prognostic value of ambulatory blood pressure. Current evidence and clinical implications. Hypertension 2000; 35: 844–851.
21. Gosse P et al. Regression of left ventricular hypertrophy in hypertensive patients treated with indapamide SR 1.5mg vs enalapril 20 mg: the LIVE study. J Hypertens 2000; 18: 1465–1475.
22. Liebson PR et al. Comparison of five antihypertensive monotherapies and placebo for change in left ventricular mass in patients receiving nutritional–hygienic therapy in the Treatment of Mild Hypertension Study (TOMHS). Circulation 1995; 91: 698–706.