Decreased glucose effectiveness but not insulin-resistance in glucose- tolerant offspring of Japanese non-insulin-dependent diabetic patients: A minimal-model analysis

Metabolism: Clinical and Experimental

Volumn 46, Issue 8, 1997, Pages 880-883

  Doi, Kentaro ^b   Taniguchi, Ataru ^a   Nakai, Yoshikatsu ^b   Kawamura, Hitomi ^b   Higaki, Yasuki ^b   Yokoi, Hideki ^b   Tanaka, Hiroaki ^b   Fujitani, Junzo ^b   Suzuki, Masashige ^b   Tokuyama, Kumpei ^b   Sakai, Masahiko ^b   Fukushima, Mitsuo ^b  

^a Kansai Denryoku Hospital   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ARTICLE; CLINICAL ARTICLE; FEMALE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PRIORITY JOURNAL;

EID: 12644257603     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(97)90073-1     Document Type: Article

References (29)

1. Laws A, Stefanick ML, Reaven GM: Insulin resistance and hypertriglyceridemia in nondiabetic relatives of patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 69:343-347, 1989
2. Eriksson J, Franssila-Kallunki A, Ekstrand A, et al: Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 321:337-343, 1989
3. Osei K, Cottrell DA, Orabella MM: Insulin sensitivity, glucose effectiveness, and body fat distribution pattern in nondiabetic offspring of patients with NIDDM. Diabetes Care 14:890-896, 1991
4. Henriksen JE, Alford F, Handberg A, et al: Increased glucose effectiveness in normoglycemic but insulin-resistant relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest 94:1196-1204, 1994
5. Banerji MA, Lebovitz HE: Insulin-sensitive and insulin-resistant variants in NIDDM. Diabetes 38:784-792, 1989
6. Taniguchi A, Nakai Y, Fukushima M, et al: Pathogenic factors responsible for glucose intolerance in patients with NIDDM. Diabetes 41:1540-1546, 1992
7. Taniguchi A, Nakai Y, Doi K, et al: Glucose effectiveness in two subtypes within impaired glucose tolerance: A minimal model analysis. Diabetes 43:1211-1217, 1994
8. Reaven GM, Hollenbeck CD, Chen Y-DI: Relationship between glucose tolerance, insulin secretion, and insulin action in non-obese individuals with varying degrees of glucose tolerance. Diabetologia 42:52-55, 1989
9. DeFronzo RA: The triumvirate: B-Cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37:667-687, 1988
10. Unger RH, Grundy S: Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: Implications for the management of diabetes. Diabetologia 28:119-121, 1985
11. Bergman RN: Toward physiological understanding of glucose tolerance: Minimal-model approach. Diabetes 38:1512-1527, 1989
12. World Health Organization: Diabetes mellitus: Report of a WHO study group. WHO Tech Rep Ser no. 727, 1985
13. Welch S, Gebhart SSP, Bergman RN, et al: Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab 71:1508-1518, 1990
14. Ader M, Pacini R, Yang YJ, et al: Importance of glucose per se to intravenous glucose tolerance. Comparison of the minimal-model prediction with direct measurements. Diabetes 34:1092-1103, 1985
15. Bergman RN, Prager R, Volund A, et al: Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest 79:790-800, 1987
16. Beard JC, Bergman RN, Ward WK, et al: The insulin sensitivity index in nondiabetic man. Correlation between clamp-derived and IVGTT-derived values. Diabetes 35:362-369, 1986
17. Press WH, Flannery SA, Teukolsky SA, et al: Numerical Recipes in Pascal. New York, NY, Cambridge University Press, 1989
18. Winer BJ: Statistical Principles in Experimental Design (ed 2). New York, NY, McGraw-Hill, 1971, pp 514-603
19. Martin BC, Warram JH, Krolewski AS, et al: Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study. Lancet 340:925-929, 1992
20. Johnston C, Ward WK, Beard JC, et al: Islet function and insulin sensitivity in the non-diabetic offspring of conjugal type 2 diabetic patients. Diabetic Med 7:119-125, 1990
21. Taniguchi A, Nakai Y, Fukushima M, et al: Insulin sensitivity, insulin secretion, and glucose effectiveness in subjects with impaired glucose tolerance: A minimal model analysis. Metabolism 43:714-718, 1994
22. Lovejoy J, DiGirolamo M: Habitual dietary intake and insulin sensitivity in lean and obese adults. Am J Clin Nutr 55:1174-1179, 1992
23. Storlein LH, James DE, Burleigh KM, et al: Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats. Am J Physiol 251:E576-E583, 1986
24. Chen M, Bergman RN, Pacini G, et al: Insulin resistance and B-cell dysfunction in aging: The importance of dietary carbohydrate. J Clin Endocrinol Metab 67:951-957, 1988
25. Nakai Y, Taniguchi A, Fukushima M, et al: Insulin sensitivity during very-low-calorie diets assessed by minimal modeling. Am J Clin Nutr 56:179S-181S, 1992 (suppl)
26. Warram JH, Martin BC, Krolewski AS, et al: Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 113:909-915, 1990
27. Rojas L, Soeldner JS, Gleason RE, et al: Offspring of two diabetic parents: Differential serum insulin responses to intravenous glucose and tolbutamide. J Clin Endocrinol 29:1569-1579, 1969
28. Finegood DT, Tzur A: Estimation of glucose effectiveness by the minimal-model is dependent on the endogenous insulin secretory response. Diabetes 44:192A, 1995 (suppl 1, abstr)
29. Taniguchi A, Nakai Y, Fukushima M, et al: Intravenous glucose tolerance test derived glucose effectiveness in bulimia nervosa. Metabolism (in press)