Prothrombotic mechanisms in preeclampsia

Thrombosis Research

Volumn 115, Issue SUPPL., 2005, Pages 17-21

  Dekker, G ^a  

^a LYELL MCEWIN HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; ALPHA 2 MACROGLOBULIN; ALPHA INTERFERON; ANGIOPOIETIN 2; BETA INTERFERON; CYTOKERATIN; DNA; FAS LIGAND; HLA C ANTIGEN; HOMOCYSTEINE THIOLACTONE; INTERLEUKIN 12; INTERLEUKIN 15; LIPOCORTIN 5; PHOSPHATIDYLSERINE; PHOSPHOLIPID BINDING PROTEIN; PLACENTAL GROWTH FACTOR; PROSTACYCLIN; PROTEIN C; PROTEIN S; THROMBOMODULIN; TRANSFORMING GROWTH FACTOR; TUMOR NECROSIS FACTOR; VASCULOTROPIN;

ANTIGEN RECOGNITION; APOPTOSIS; BLOOD FLOW; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL INFILTRATION; CELL INVASION; CELL VIABILITY; CONFERENCE PAPER; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; DISEASE SEVERITY; ENDOTHELIUM CELL; HOST RESISTANCE; HUMAN; LEUKOCYTE; MACROPHAGE ACTIVATION; MATERNAL BLOOD; MONOCYTE; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PHENOTYPE; PLACENTA DEVELOPMENT; POLYMORPHIC LOCUS; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; THROMBOPHILIA; TROPHOBLAST; VASCULAR RESISTANCE; VASODILATATION;

ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; INFLAMMATION; PLACENTAL CIRCULATION; PRE-ECLAMPSIA; PREGNANCY; THROMBOPHILIA; TROPHOBLASTS;

EID: 12544260155     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (34)

1. Aly AS, Khandelwal M, Zhao J, Mehmet AH, Sammel MD, Parry S. Neutrophils are stimulated by syncytiotrophoblast microvillous membranes to generate superoxide radicals in women with preeclampsia. Am J Obstet Gynecol 2004;190:252-8.
2. Benyo DF, Smarason A, Redman CW, Sims C, Conrad KP. Expression of inflammatory cytokines in placentas from women with preeclampsia. J Clin Endocrinol Metab 2001;86:2505-12.
3. Brodsky SV, Zhang F, Nasjletti A, Golligorsky MS. Endothelium-derived microparticles impair endothelial function in vitro. Am J Physiol Heart Circ Physiol 2004:286:H1910-5.
4. Chaiworapongsa T, Romero R, Espinoza J, Bujold E, Mee Kim Y, Goncalves LF, Gomez R, Edwin S. Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia. Young Investigator Award. Am J Obstet Gyneco 2004;190:1541-7.
5. Croy BA, He H, Esadeg S, Wei Q, McCartney D, Zhang J, Borzychowski A, Ashkar AA, Black GP, Evans SS, Chantakru S, van den Heuvel M, Paffaro VA, Yamada AT. Uterine natural killer cells; insight into their cellular and molecular biology from mouse modeling. Reproduction 2003;126:149-60.
6. Dekker GA, Sibai BM: Etiology and Pathogenesis of Preeclampsia: Current Concepts. Am J Obstet Gynecol 1998;179:1359-75.
7. Estelles A, Gilabert J, Grancha S, et al. Abnormal expression of type I plasminogen activator inhibitor and issue factor in severe preeclampsia. Thromb Haemost 1998;79:500-8.
8. Haig D. Genetic conflicts in human pregnancy. Quarterly Review of Biology 1993;68:495-532.
9. Hung TH, Charnock-Jones DS, Skepper JN, Burton GJ. Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia -reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia. Am J Pathol 2004;164:1049-61.
10. Ishihara N, Matsuo H, Murakoshi H, Laoag-Fernandez JB, Samoto T, Maruo T. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol 2002;186:158-66.
11. Kamudhamas A, Pang L, Smith SD, Sadovsky Y, Nelson DM. Homocysteine thiolactone induces apoptosis in cultured trophoblasts: A mechanism for homocysteine-mediated placental dysfunction? Am J Obstet Gynecol 2004;191:563-71.
12. Kupferminc MJ. Thrombophilia and pregnancy. Reprod Biol Endocrinol 2003(Nov 14);1(1):111.
13. Lanir N, Aharon A, Brenner B. Haemostatic mechanisms in human placenta. Best Practice and Research Clinical Haematology 2003;16:183-95.
14. Lanir N, Aharon A, Tennenbaum G, Brenner B. Cultured human placenta trophoblasts express vascular haemostatic function that are affected by cytokines. Thrombosis and Haemostasis 2001;(supplement):P-2057.
15. Levine RJ, Qian C, Leshane ES, Yu KF, England LJ, Schisterman EF, Wataganara T, Romero R, Bianchi DW. Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia. Am J Obstet Gynecol 2004(Mar); 190(3):707-13.
16. Lo YM, Leung TN, Tein MS, Sargent IL, Zhang J, Lau TK, Haines CJ, Redman CW. Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia. Clin Chem 1999(Feb);45(2):184-8.
17. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, S. Ananth KJ. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. Clin Invest 2003;111:649-58.
18. Moffett-King A. Natural Killer Cells and Pregnancy Nature Review Immunology 2002;2:656-63.
19. Mor G, Straszewski S, Kamsteeg M. Role of the Fas/Fas ligand system in female reproductive organs: survival and apoptosis. Biochem Pharmacol 2002;64:1305-15.
20. Moretti M, Phillips M, Abouzeid A, Cataneo RN, Greenberg J. Increased breath markers of oxidative stress in normal pregnancy and in preeclampsia. Am J Obstet Gynecol 2004;190:1184-90.
21. Neale D, Demasio K, Illuzi J, Chaiworapongsa T, Romero R, Mor G. Maternal serum of women with pre-eclampsia reduces trophoblast cell viability: evidence for an increased sensitivity to Fasmediated apoptosis. J Matern Fetal Neonatal Med 2003;13:39-44.
22. Rand J. The annexinpathies: a new category of disease (review). Biochimica et Biophysica Acta 2000;1498:169-73.
23. Redline RW, Boyd T, Campbell V, Hyde S, Kaplan C, Khong TY, Prashner HR, Waters BL. Society for Pediatric Pathology, Perinatal Section, Maternal Vascular Perfusion Nosology Committee. Maternal vascular underperfusion: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol 2004;7:237-49.
24. Redman CWG, Sargent IL. Pre-eclampsia, the Placenta and the Maternal Systemic Inflammatory Response-A Review. Placenta 2003;24:S21-7.
25. Redman CW, Sargent IL. Placental debris, oxidative stress and pre-eclampsia. Placenta 2000;21:597-602.
26. Robertson SA, Ingman WV, O'Leary S, Sharkey DJ, Tremellen KP. Transforming growth factor beta - a mediator of immune deviation in seminal plasma. J Reprod Immunol 2002;57:109-28.
27. Sacks GP, Redman CW, Sargent IL. Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells. Clin Exp Immunol 2003;131:490-7.
28. Saito S, Sakai M. Th1/Th2 balance in preeclampsia. J Reprod Immunol 2003;59:161-73.
29. Sargent IL, Germain SJ, Sacks GP, Kumar S, Redman 1CW. Trophoblast deportation and the maternal inflammatory response in pre-eclampsia. J Reprod Immunol 2003;59:153-60.
30. Savvidou MD, Hingorani AD, Tsikas D, Frolich JC, Vallance P, Nicolaides KH. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia. Lancet 2003;361:1511-7.
31. Shu F, Sugimura Mkanayama N, Kobayashi H, Kobayashi T, Terao T. Immunohistochemical study of annexin V expression in placentae of preeclampsia. Gynecol Obstet Invest 2000;49:17-23.
32. Sibai BM, Dekker GA, Kupferminc M. Preeclampsia; An Update on its Causation, Diagnosis, Prevention and Management. Lancet [in press].
33. Walsh SW. Preeclampsia: an imbalance in placental prostacyclin and thromboxane production. Am J Obstet Gynecol 1985;23:311-4.
34. Wang JX, Knottnerus AM, Schuit G, Norman RJ, Chan A, Dekker GA. Surgically obtained sperm, and risk of gestational hypertension and preeclampsia. Lancet 2002;359:673-4.