Defective annexin A5 crystallization: A mechanism for pregnancy losses in the antiphospholipid syndrome

Thrombosis Research

Volumn 115, Issue SUPPL., 2005, Pages 77-81

  Rand, J ^a   Eerden, P V ^a   Wu, X X ^a   Chazotte, C ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN G; LIPOCORTIN 5;

ANTIPHOSPHOLIPID SYNDROME; AUTOIMMUNE DISEASE; BIOLOGY; CHORIOCARCINOMA; CONFERENCE PAPER; CRYSTAL STRUCTURE; CRYSTALLIZATION; GESTATIONAL AGE; HUMAN; PATHOLOGY; PREGNANCY COMPLICATION; PREGNANCY DISORDER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPONTANEOUS ABORTION; THROMBOSIS;

ABORTION, SPONTANEOUS; ANIMALS; ANNEXIN A5; ANTIPHOSPHOLIPID SYNDROME; AUTOANTIBODIES; CRYSTALLIZATION; FEMALE; HUMANS; MICROSCOPY, ATOMIC FORCE; PREGNANCY; TROPHOBLASTS;

EID: 12544249615     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (21)

1. Krikun G, Lockwood CJ, Wu XX, Zhou XD, Guller S, Calandri C, Guha A, Nemerson Y, Rand JH. The expression of the placental anticoagulant protein, annexin V, by villous trophoblasts: immunolocalization and in vitro regulation. Placenta 1994;15:601-12.
2. Donohoe S, Kingdom JC, Mackie IJ, Burrell S, Quenby S, Jauniaux E, Machin SJ. Ontogeny of beta 2 glycoprotein I and annexin V in villous placenta of normal and antiphospholipid syndrome pregnancies. Thromb Haemost 2000;84:32-8.
3. Reviakine I, Bergsma-Schutter W, Mazeres-Dubut C, Govorukhina N, Brisson A: Surface topography of the p3 and p6 annexin V crystal forms determined by atomic force microscopy. J Struct Biol 2000;131:234-9.
4. Reviakine I, Bergsma-Schutter W, Brisson A. Growth of Protein 2-D Crystals on Supported Planar Lipid Bilayers Imaged in Situ by AFM. J Struct Biol 1998;121:356-61.
5. Rand JH, Wu XX, Quinn AS, Chen PP, McCrae KR, Bovill EG, Taatjes DJ. Human monoclonal antiphospholipid antibodies disrupt the annexin a5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assay. Am J Pathol 2003;163:1193-200.
6. Rand JH, Wu XX, Andree HA, Lockwood CJ, Guller S, Scher J, Harpel PC. Pregnancy loss in the antiphospholipid-antibody syndrome-a possible thrombogenic mechanism. N Engl J Med 1997;337:154-60.
7. Wang X, Campos B, Kaetzel MA, Dedman JR. Annexin V is critical in the maintenance of murine placental integrity. Am J Obstet Gynecol 1999;180:1008-16.
8. Rand JH. The antiphospholipid syndrome. Ann Rev Med 2003;54:409-24.
9. Branch DW, Khamashta MA. Antiphospholipid syndrome: obstetric diagnosis, management, and controversies. Obstet Gynecol 2003;101:1333-44.
10. Salafia CM. Placental pathology of fetal growth restriction. Clin Obstet Gynecol 1997;40:740-9.
11. Matsubayashi H, Arai T, Izumi S, Sugi T, McIntyre JA, Makino T. Anti-annexin V antibodies in patients with early pregnancy loss or implantation failures. Fertil Steril 2001;76:694-9.
12. Rand JH, Wu XX, Guller S, Gil J, Guha A, Scher J, Lockwood CJ. Reduction of annexin-V (placental anticoagulant protein-I) on placental villi of women with antiphospholipid antibodies and recurrent spontaneous abortion. Am J Obstet Gynecol 1994;171:1566-72.
13. Rand JH, Wu XX, Guller S, Scher J, Andree HAM, Lockwood CJ. Antiphospholipid immunoglobulin G antibodies reduce annexin-V levels on syncytiotrophoblast apical membranes and in culture media of placental villi. Am J Obstet Gynecol 1997;177:918-23.
14. Lakasing L, Campa JS, Poston R, Khamashta MA, Poston L. Normal expression of tissue factor, thrombomodulin, and annexin V in placentas from women with antiphospholipid syndrome. Am J Obstet Gynecol 1999;181:180-9.
15. Matsuda J, Gotoh M, Saitoh N, Gohchi K, Tsukamoto M, Yamamoto T. Anti-annexin antibody in the sera of patients with habitual fetal loss or preeclampsia. Thromb Res 1994;75:105-6.
16. Arnold J, Holmes Z, Pickering W, Farmer C, Regan L, Cohen H. Anti-beta 2 glycoprotein 1 and anti-annexin V antibodies in women with recurrent miscarriage. Br J Haematol 2001;113:911-4.
17. Arai T, Matsubayashi H, Sugi T, Kondo A, Shida M, Suzuki T, Izumi SI, McIntyre JA, Makino T. Anti-annexin A5 antibodies in reproductive failures in relation to antiphospholipid antibodies and phosphatidylserine. Am J Reprod Immunol 2003;50:202-8.
18. Gris JC, Perneger TV, Quere I, Mercier E, Fabbro-Peray P, Lavigne-Lissalde G, Hoffet M, Dechaud H, Boyer JC, Ripart-Neveu S, Tailland ML, Daures JP, Mares P, Dauzat M. Antiphospholipid/antiprotein antibodies, hemostasisrelated autoantibodies, and plasma homocysteine as risk factors for a first early pregnancy loss: a matched case-control study. Blood 2003;102:3504-13.
19. Gris JC, Quere I, Sanmarco M, Boutiere B, Mercier E, Amiral J, Hubert AM, Ripart-Neveu S, Hoffet M, Tailland ML, Rousseau O, Monpeyroux F, Dauzat M, Sampol J, Daures JP, Berlan J, Mares P. Antiphospholipid and antiprotein syndromes in non-thrombotic, non-autoimmune women with unexplained recurrent primary early foetal loss. The Nimes Obstetricians and Haematologists Study-NOHA. Thromb Haemost 2000;84:228-36.
20. Makino T. Recurrent reproductive wastage and immunologic factors. Am J Reprod Immunol 2002;48:266-8.
21. Di Simone N, Castellani R, Caliandro D, Caruso A. Monoclonal anti-annexin V antibody inhibits trophoblast gonadotropin secretion and induces syncytiotrophoblast apoptosis. Biol Reprod 2001;65:1766-70.