Usefulness of alpha-fetoprotein in the diagnosis of hepatocellular carcinoma

Anticancer Research

Volumn 23, Issue 2 C, 2003, Pages 1747-1753

  Soresi, Maurizio ^a   Magliarisi, Carmela ^a   Campagna, Pietro ^a   Leto, Gaetano ^b   Bonfissuto, Giulio ^a   Riili, Anna ^a   Carroccio, Antonio ^a   Sesti, Roberta ^a   Tripi, Silvio ^a   Montalto, Giuseppe ^a,c  

^a Dipartimento di Medicina Clinica e delle Patologie Emergenti   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c Cattedra di Medicina Interna   (Italy)

Author keywords

Fetoprotein; Diagnosis; Hepatocellular carcinoma; Liver cirrhosis; Ultrasound

Indexed keywords

ALPHA FETOPROTEIN;

ADULT; AGED; ARTICLE; CANCER STAGING; CORRELATION ANALYSIS; DISEASE CLASSIFICATION; HEPATITIS B; HEPATITIS C; HORMONE BLOOD LEVEL; HUMAN; ITALY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FUNCTION; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; POPULATION; PREDICTION; PRIORITY JOURNAL; SCORING SYSTEM; SENSITIVITY ANALYSIS; STATISTICAL SIGNIFICANCE; VIRUS INFECTION;

AGED; ALPHA-FETOPROTEINS; AREA UNDER CURVE; CARCINOMA, HEPATOCELLULAR; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; ROC CURVE;

EID: 12444342437     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Alport ME, Uriel J and De Nechaud B: Alpha-fetoglobulin in the diagnosis of human hepatoma. N Engl J Med 278: 984-86, 1968.
2. Wespic H, Kirkpatrick A: Alpha-fetoprotein and its elevance to human disease. Gastroenterology 77: 787-96, 1979.
3. Kew M: Alpha-fetoprotein in primary liver cancer and other disease. Gut 14: 814-21, 1974.
4. Rueslahti E, Pihko H and Seppala M: Alpha-fetoprotein: Immunochemical purification and chemical properties. Expression in normal state and in malignant and non malignant liver disease. Transplant Rev 20: 38-40, 1974.
5. Mc Intire KR, Waldmann TA, Go VL et al: Simultaneous radioimmunoassay for carcinoembryonic antigen (CEA) and alpha-phetoprotein in neoplasm of the gastrointestinal tract. Ann Ciln Lab Sci 4: 104-8, 1974.
6. Bayati N, Silverman AL and Gordon SC: Serum alpha-fetoprotein levels and liver histology in patients with chronic hepatitis C. Am J Gastroenterol 93: 2456-6, 1998.
7. Goldstein NS, Blue DE, Hankin R, Hunter S, Bayati N, Silverman AL and Gordon SC: Serum alpha-fetoprotein levels in patients with chronic hepatitis C. Relationship with serum alanine aminotransferase values, histologic activity index, and hepatocyte MIB-1 scores. Am J Clin Pathol 111: 811-6, 1999.
8. Chen DS, Sung JL, Sheu JC, Lay MY, How SW, Hsu HC, Lee CS et al: Serum alpha-fetoprotein in the early stage of human hepatocellular carcinoma. Gastroenterology 86: 1404-9, 1984.
9. Liaw JF, Tai DI, Chu CM, Lin DY, Sheen IS, Chen TJ and Pao CC: Early detection of hepatocellular carcinoma in patients with chronic type B hepatitis. Gastroenterology 90: 263-7, 1986.
10. Colombo M, de Franchis R, Del Ninno E, Sangiovanni A, De Fazio C, Tommasini M, Donato MF et al: Hepatocellular carcinoma in Italian patients with cirrhosis. N Engl J Med 325: 675-80, 1991.
11. Oka H, Tamori A, Kuroki T, Kobayashi K and Yanamoto S: Prospective study of alpha-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma. Hepatology 19: 61-6, 1994.
12. Bolondi L, Sofia S, Siringo S, Gaiani S, casali A, Zironi G, Piscaglia F, Gramantieri L, Zanetti M and Sherman M: Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis. Gut 48: 251-9, 2001.
13. Alpert E, Starzl TE and Schur PH: Serum alpha-fetoprotein in hepatoma patients after liver transplantation. Gastroenterology 61: 144-88, 1971.
14. Nomura F, Ohnishi K and Tanabe Y: Clinical features and prognosis of hepatocellular carcinoma with reference to serum alpha-fetoprotein levels: Analysis of 606 patients. Cancer 64: 1700-7, 1989.
15. Soresi M, Carroccio A, Bonfissuto G, Magliarisi C, Campagna P, Vuturo O, D'antona F and Montalto G: Presentazione ecografica dell'epatocarcinoma in una popolazione siciliana. Giorn It Ecografia 3: 21-4, 2000.
16. Kondo F, Wada K, Nagato Y et al: Biopsy diagnosis of well-differentiated hepatocellular carcinoma based on new morphologic criteria. Hepatology 9: 751-5, 1989.
17. Brum C, Schulze C, Charles K et al: The significance of alpha-fetoprotein and other tumor markers in differential immunocytochemistry of primary liver tumors. Histopathology 14: 503-13, 1989.
18. Lee HS, Chung YH and Kim CY: Specificities of serum alpha-fetoprotein in HBsAg+ and HBsAg- patients in the diagnosis of hepatocellular carcinoma. Hepatology 14: 68-72, 1991.
19. Stroffolini T, Andreone P, Andriulli A, Ascione A, Craxi A, Chiaramonte M et al: Characteristics of hepatocellular carcinoma in Italy. J Hepatol 29: 944-52, 1998.
20. Furui J, Furukawa M and Kanematsu T: The low positive rate of serum alpha-fetoprotein levels in hepatitis C virus antibody-positive patients with hepatocellular carcinoma. Hepato-Gastroenterology 42: 445-9, 1995.
21. Carroccio A, Soresi M, Bonfissuto G, Magliarisi C, Anastasi G, Vuturo O, Notarbartolo A and Montalto G: Aspetti clinici ed eziologici dell'epatocarcinoma in Sicilia. Ann It Med Int 14: 233-8, 1999.
22. Trevisani F, D'Intino PE, Morselli-Labate AM, Mazzella G, Accogli E, Caraceni P et al: Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status. J Hepatol 34: 570-5 2001.
23. Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MC and Williams R: Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 60: 646-9, 1973.
24. Okuda K, Ohtsuki T, Obata H, Tomimatsu M, Okazaki N, Hasegawa H, Nakajima Y and Ohnishi K: Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer 56: 918-28, 1985.
25. Spiessl B, Beahrs OH, Hermanek P et al: TNM Atlas, Illustrated guide to the TNM/pTNM-Classification of Malignant Tumors. 3rd edition Berlin: Springer Verlag, 98-105, 1989.
26. Edmonson HA and Steiner PE: Primary carcinoma of the liver. A study of 100 cases among 48,900 necropsies. Cancer 7: 462-503, 1954.
27. Montalto G, Iovanna JL, Soresi M, Dusetti N, Carroccio A, Barthelemy-Bialas S, Cartabellotta A and Dagorn JC: Clinical evaluation of pancreatitis-associated protein as a serum markers of hepatocellular carcinoma. Comparison with alpha-fetoprotein. Oncology 55: 421-5, 1998.
28. Zweig MH and Campbell G: Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chen 39: 561-77, 1993.
29. Pezzilli R, Morselli-Labate AM, Miniero R, Barakat B, Fiocchi M and Cappelletti O: Simultaneous serum assay of lipase and inteleukin-6 for early diagnosis of prognosis acute pancreatitis. Clin Chem 45: 1762-7, 1999.
30. Sox HC, Blatt MA, Higgins MC and Marton K: Medical Decision-Making. London, Butterworth 67-146, 1989.
31. Ishii M, Gama H, Chida N, Ueno Y, Shinzawa H, Tagaki T et al. Simultaneous measurements of serum alpha-fetoprotein and protein induced by vitamin k absence for detecting hepatocellular carcinoma. Am J Gastroenterol 95: 1036-40, 2000.