New styryl sulfones as anticancer agents

European Journal of Medicinal Chemistry

Volumn 38, Issue 9, 2003, Pages 811-824

  Vedula, Manohar Sharma ^a   Pulipaka, Aravind Babu ^a   Venna, Chandrasekhar ^a   Chintakunta, Vamsee Krishna ^a   Jinnapally, Sreenu ^a   Kattuboina, Venkata Adiseshu ^a   Vallakati, Ravi Krishna ^a   Basetti, Vishnu ^a   Akella, Venkateswarlu ^a   Rajgopal, Sriram ^a   Reka, Ajaya Kumar ^a   Teepireddy, Sravan Kumar ^a   Mamnoor, Prem Kumar ^a   Rajagopalan, Ramanujam ^a   Bulusu, Gopalakrishnan ^a   Khandelwal, Akash ^a   Upreti, Vijay V ^a   Mamidi, Srinivas Rao ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

Anti cancer activity; MAP kinase inhibitors; Substituted benzimidazole styryl sulfones

Indexed keywords

6 CHLORO 1H BENZ[D]IMIDAZOL 2 YLMETHYL [2 (4 CHLORO 3 METHYLPHENYL) 1 ETHENYL]SULFONE; ANTINEOPLASTIC AGENT; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 12444337204     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(03)00144-2     Document Type: Article

References (15)

1. Pelech S.L., Sanghera J.S. Science. 257:1992;1355.
2. Davis R.J. J. Biol. Chem. 268:1993;14553.
3. Nishida E., Gotoh Y. Trends Biochem. Sci. 18:1993;128.
4. Blumer K.J., Johnson G.L. Trends Biochem. Sci. 19:1994;236.
5. Posada J., Cooper J.A. Science. 255:1992;212.
6. Biggs W.H. III, Zipursky S.L. Proc. Natl. Acad. Sci. USA. 89:1992;6295.
7. Gartner A., Nasmyth K., Ammerer G. Genes Dev. 7:1992;1280.
8. Derijard B., Hibi M., Wu I.H., Barrett T., Su B., Deng T., Karin M., Davis R.J. Cell. 76:1994;1025.
9. Adler V., Franklin C.C., Kraft A.S. Proc. Natl. Acad. Sci. USA. 89:1992;5341.
10. Klebe G., Abraham U., Mietzner T. J. Med. Chem. 37:1994;4130.
11. Bohm M., Stuzerbercher J., Kliebe G. J. Med. Chem. 42:1999;458.
12. Marks A., Scudiero D., Skehan P., Shoemaker R., Paull K., Vistica D., Hose C., Langley J., Cronise P., Vaigro-Wolff A., Gray-Goodrich M., Campbell H., Mayo J., Boyd M. J. NaH. Cancer Inst. 83:1991;757.
13. Rusnak D.W., Lackey K., Affleck K. Mol. Cancer Ther. 1:2001;85.
14. Gibaldi M., Perrier D., Swarbrick J. Pharmacokinetics. 4:1982;149 Marcel Dekker, New York.
15. SYBYL 6.8, Tripos Associates: St. Louis, MO, USA.