Oral risperidone with lorazepam versus oral zuclopenthixol with lorazepam in the treatment of acute psychosis in emergency psychiatry: A prospective, comparative, open-label study

Journal of Psychopharmacology

Volumn 19, Issue 1, 2005, Pages 51-57

  Hovens, J E ^a   Dries, P J T ^a   Melman, C T M ^b   Wapenaar, R J C ^b   Loonen, A J M ^a  

^a Delta Psychiatrisch Ziekenhuis   (Netherlands)

^b Janssen Cilag BV Netherlands   (Netherlands)

Author keywords

Acute; Emergency psychiatry; Oral; Risperidone; Zuclopenthixol

Indexed keywords

ANTIPARKINSON AGENT; LORAZEPAM; RISPERIDONE; ZUCLOPENTHIXOL;

ACUTE PSYCHOSIS; ADULT; AGGRESSION; AGITATION; ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; EMERGENCY WARD; EXTRAPYRAMIDAL SYMPTOM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OPEN STUDY; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; SOCIAL DISABILITY;

ADOLESCENT; ADULT; AGED; AGGRESSION; ANTI-ANXIETY AGENTS; ANTIPSYCHOTIC AGENTS; CLOPENTHIXOL; DRUG THERAPY, COMBINATION; EMERGENCY MEDICAL SERVICES; ENDPOINT DETERMINATION; FEMALE; HUMANS; LORAZEPAM; MALE; MIDDLE AGED; PERSONNEL, HOSPITAL; PROSPECTIVE STUDIES; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMOTOR PERFORMANCE; PSYCHOTIC DISORDERS; RISPERIDONE; SOCIAL BEHAVIOR;

EID: 12444329714     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/0269881105048897     Document Type: Article

References (40)

1. Allen M H (2000) Managing the agitated psychotic patient: a reappraisal of the evidence. J Clin Psychiatry 61 (Suppl 14): 11-20
2. American Psychiatric Association (1994) Diagnostic and Statistical Manual for Mental Disorders, 4th edn. American Psychiatric Association, Washington, DC
3. Binder R L, McNiel D E (1999) Emergency psychiatry: contemporary practices in managing acutely violent patients in 20 psychiatric emergency rooms. Psychiatr Serv 50: 1553-1554
4. Buckley P, Bartell J, Donenwirth K, Lee S, Torigoe F, Schulz SC (1995) Violence and schizophrenia: clozapine as a specific antiaggressive agent. Bull Am Acad Psychiatry Law 23: 607-611
5. Buckley P F (1999) The role of typical and atypical antipsychotic medications in the management of agitation and aggression. J Clin Psychiatry 60 (Suppl 10): 52-60
6. Csernansky J G, Schuchart E K (2002) Relapse and rehospitalisation rates in patients with schizophrenia. Effects of second generation antipsychotics. CNS Drugs 16: 473-484
7. Csernansky J G, Mahmoud R, Brenner R, the Risperidone-USA-79 Study Group (2002) A comparison of risperidone and haloperidol for the prevention of relapse in patients with schizophrenia. N Engl J Med 346: 16-22
8. Currier G W (2000) Atypical antipsychotics in the psychiatric emergency services. J Clin Psychiatry 61 (Suppl 14): 21-26
9. Currier G W, Simpson G M (2001) Risperidone liquid concentrate and oral lorazepam versus intramuscular haloperidol and intramuscular lorazepam for treatment of psychotic agitation. J Clin Psychiatry 62: 153-157
10. Czobor P, Volavka J, Meibach R C (1995) Effect of risperidone on hostility in schizophrenia. J Clin Psychopharmacol 15: 243-249
11. De Hert M, Wampers M, Thys E, Wieselgrem IM, Lindstrom E, Peuskens (2002) Validation study of PECC (Psychosis Evaluation tool for Common use by Caregivers): interscale validity and inter-rater reliability. Int J Psych Clin Prac 6: 135-140
12. European Rating Aggression Group (1992) Social dysfunction and aggression scale (SDAS-21) in generalized aggression and in aggressive attacks: a validity and reliability study. Int J Meth Psychiatr Res 2: 15-29
13. Expert Consensus Guidelines Series (1999) Treatment of schizophrenia. J Clin Psychiatry 60 (Suppl 11): 3-80
14. Fava M (1997) Psychopharmacologic treatment of pathologic aggression. Psychiatr Clin North Am 20: 427-451
15. Feifel D (2000) Rationale and guidelines for the inpatient treatment of acute psychosis. J Clin Psychiatry 61 (Suppl 14): 27-32
16. Foster S, Kessel J, Berman M E, Simpson G M (1997) Efficacy of lorazepam and haloperidol for rapid tranquilization in a psychiatric emergency room setting. Int Clin Psychopharmacol 12: 175-179
17. Gutierrez-Esteinou R, Grebb J A (1997) Risperidone: an analysis of the first three years in general use. Int Clin Psychopharmacol 12 (Suppl 4): S3-S10
18. Hellewell J S E, Cameron-Hands D, Cantillon M (1998) Seroquel: evidence for efficacy in the treatment of hostlity and aggression. Schizophr Res 29: 154-155
19. Hillard J R (1998) Emergency treatment of acute psychosis. J Clin Psychiatry 59 (Suppl 1): 57-60
20. Huttunen M O, Piepponen T, Rantanen H, Larmo I, Nyholm R, Raitasuo V (1995) Risperidone versus zuclopenthixol in the treatment of acute schizophrenic episodes: a double-blind parallel-group trial. Acta Psychiatr Scand 91: 271-277
21. Kay S R, Fiszbein A, Opler L A (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13: 261-276
22. Kent S, Yellowlees P (1994) Psychiatric and social reasons for frequent rehospitalization. Hosp Commun Psychiatry 45: 347-350
23. Knapp M (2000) Schizophrenia costs and treatment cost-effectiveness. Acta Psychiatr Scand Suppl 102: 15-18
24. Leucht S, Pitschel-Walz G, Abraham D, Kissling W (1999) Efficacy and extrapyramidal side-effects of the new antipsychotics olazapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials. Schizophr Res 35: 51-68
25. Levy R H (1996) Sedation in acute and chronic agitation. Pharmacotherapy 16: 152S-159S
26. Marder S R, Meibach R C (1994) Risperidone in the treatment of schizophrenia. Am J Psychiatry 151: 825-835
27. Marder S R, Davis J M, Chouinard G (1997) The effects of risperidone on the five dimensions of schizophrenia derived by factor analysis: combined results of the North American trials. J Clin Psychiatry 58: 538-546
28. Menuck M, Voineskos G (1981) Rapid parenteral treatment of acute psychosis. Compr Psychiatry 22: 351-361
29. National Institute of Mental Health (1976) CGI: clinical global impressions. In Guy W (ed.), ECDEU Assessment Manual of Psychopharmacology, rev. edn. US Department of Health, Education and Welfare Publicaation (ADM) 76-38. National Institute of Mental Health, Rockville, MD, pp. 217-22
30. Olfson M, Mechanic D, Hanseil S, Boyer C A, Walkup J, Weiden P J (2000) Predicting medication non-compliance after hospital discharge among patients with schizophrenia. Psychiatr Serv 51: 216-222
31. Peuskens J, for the Risperidone Study Group (1995) Risperidone in the treatment of patients with chronic schizophrenia: a multi-national, multi-centre, double-blind, parallel-group study versus haloperidol. Br J Psychiatry 166: 712-726
32. Pickar D (1995) Prospects for pharmacotherapy of schizophrenia. Lancet 345: 557-562
33. Sharif Z A (1998) Common treatment goals of antipsychotics: acute treatment. J Clin Psychiatry 59 (Suppl 19): 5-8
34. Song F (1997) Risperidone in the treatment of schizophrenia: a meta-analysis of randomized controlled trials. J Psychopharmacol 11: 65-71
35. Tollefson G D, Beasley C M Jr, Tran P V, Street J S, Krueger J A, Tamura R N, Gratteo K A, Thieme M E (1997) Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorders: results of an international collaborative trial. Am J Psychiatry 154: 457-465
36. Van Schaick E A, Lechat P, Remmerie B M M, Ko G, Lasseter K C, Mannaert E (2003) Pharmacokinetic comparison of fast-disintegrating and conventional tablet formulations of risperidone in healthy volunteers. Clin Ther 5: 1687-1699
37. Volavka J, Zito J, Vitrai J, Czobar P (1993) Clozapine effects on hostility and aggression in schizophrenia. J Clin Psychopharmacol 13: 287-9
38. Weiden P J, Olfson M (1995) Cost of relapse in schizophrenia. Schizophr Bull 21: 419-429
39. Wolkowitz O M, Pickar D (1991) Benzodiazepines in the treatment of schizophrenia: a review and reappraisal. Am J Psychiatry 148: 714-726
40. Zhang X Y, Zhou D F, Cao L Y, Zhang P Y, Wu G Y, Shen Y C (2001) Risperidone versus haloperidol in the treatment of acute exacerbations of chronic inpatients with schizophrenia: a randomized double-blind study. Int Clin Psychopharmacol 16: 325-330