Haptoglobin-α subunit as potential serum biomarker in ovarian cancer: Identification and characterization using proteomic profiling and mass spectrometry

Clinical Cancer Research

Volumn 9, Issue 8, 2003, Pages 2904-2911

  Ye, Bin ^a   Cramer, Daniel W ^a,b   Skates, Steven J ^c   Gygi, Steven P ^b   Pratomo, Vanessa ^a   Fu, Lanfei ^a   Horick, Nora K ^c   Licklider, Larry J ^b   Schorge, John O ^d   Berkowitz, Ross S ^a,b   Mok, Samuel C ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HAPTOGLOBIN; PROTEIN SUBUNIT; TUMOR MARKER;

ALPHA CHAIN; ARTICLE; DIAGNOSTIC ACCURACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IONIZATION; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; OVARY CANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; SENSITIVITY AND SPECIFICITY;

AMINO ACID SEQUENCE; BIOTIN; BLOTTING, WESTERN; CA-125 ANTIGEN; DIMERIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENITAL NEOPLASMS, FEMALE; HAPTOGLOBINS; HUMANS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVARIAN NEOPLASMS; PEPTIDES; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 12444310169     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Daly, M. B., and Ozols, R. F. The search for predictive patterns in ovarian cancer: proteomics meets bioinformatics. Cancer Cell, 1: 111-112, 2002.
2. Mills, G. B., Bast, R. C., Jr., and Srivastava, S. Future for ovarian cancer screening: novel markers from emerging technologies of transcriptional profiling and proteomics. J. Natl. Cancer Inst. (Bethesda), 93: 1437-1439, 2001.
3. Bast, R. C., Jr., Klug, T. L., St. John, E., Jenison, E., Niloff, J. M., Lazarus, H., Berkowitz, R. S., Leavitt, T., Griffiths, C. T., Parker L., Zurawski, V. R., Jr., and Knapp, R. C. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N. Engl. J. Med., 309: 883-887, 1983.
4. Mok, S. C., Chao, J., Skates, S., Wong, K., Yiu, G. K., Muto, M. G., Berkowitz, R. S., and Cramer, D. W. Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology. J. Natl. Cancer Inst. (Bethesda), 93: 1458-1464, 2001.
5. Kim, J. H., Skates, S. J., Uede, T., Wong, K. K., Schorge, J. O., Feltmate, C. M., Berkowitz, R. S., Cramer, D. W., and Mok, S. C. Osteopontin as a potential diagnostic biomarker for ovarian cancer. JAMA, 287: 1671-1679, 2002.
6. Petricoin, E. F., Ardekani, A. M., Hitt, B. A., Levine, P. J., Fusaro, V. A., Steinberg, S. M., Mills, G. B., Simone, C., Fishman, D. A., Kohn, E. C., and Liotta, L. A. Use of proteomic patterns in serum to identify ovarian cancer. Lancet, 359: 572-577, 2002.
7. Vlahou, A., Schellhammer P. F., Mendrinos, S., Patel, K., Kondylis, F. I., Gong, L., Nasim, S., and Wright G. L., Jr. Development of a novel proteomic approach for the detection of transitional cell carcinoma of the bladder in urine. Am. J. Pathol., 158: 1491-1502, 2001.
8. Cramer, D. W., Kuper, H., Harlow, B. L., and Titus-Ernstoff, L. Carotenoids, antioxidants and ovarian cancer risk in pre- and postmenopausal women. Int. J. Cancer, 94: 128-134, 2001.
9. Shevchenko, A., Wilm, M., Vorm O., and Mann, M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem., 68: 850-858, 1996.
10. Mann, M., Hendrickson, R. C., and Pandey, A. Analysis of proteins and proteomes by mass spectrometry. Annu. Rev. Biochem., 70: 437-473, 2001.
11. Peng, J., and Gygi, S. P. Proteomics: the move to mixtures. J. Mass. Spectrom., 36: 1083-1091, 2001.
12. Shindo, S. Haptoglobin subtyping with anti-haptoglobin alpha chain antibodies. Electrophoresis, 11: 483-488, 1990.
13. Altin J. G., and Pagler, E. B. A one-step procedure for biotinylation and chemical cross-linking of lymphocyte surface and intracellular membrane-associated molecules. Anal. Biochem., 224: 382-389, 1995.
14. Stone, M. Cross-validatory Choice and Assessment of Statistical Predictions. J. R. Stat. Soc. (B), 36: 111-147, 1974.
15. Maeda, N., Yang, F. Barnett, D. R., Bowman B. H. and Smithies, O. Duplication within the haptoglobin Hp2 gene. Nature (Lond.), 309: 131-135, 1984.
16. Petricoin E. F. III, Ornstein, D. K., Paweletz C. P., Ardekani, A., Hackett P. S., Hitt B. A., Velassco A., Trucco C., Wiegand L., Wood, K., Simone, C. B., Levine, P. J., Linehan, W. M., Emmert-Buck, M. R., Steinberg, S. M., Kohn, E. C., and Liotta, L. A. Serum proteomic patterns for detection of prostate cancer. J. Natl. Cancer Inst. (Bethesda), 94: 1576-1578, 2002.
17. Schrader, M., and Schulz-Knappe, P. Peptidomics technologies for human body fluids. Trends Biotechnol., 19: S55-S60, 2001.
18. Knopman, D. Cerebrospinal fluid beta-amyloid and tau proteins for the diagnosis of Alzheimer disease. Arch. Neurol., 58: 349-350, 2001.
19. Zhang, L., Yu, W., He, T., Yu, J., Caffrey, R. E., Dalmasso, E. A., Fu, S., Pham, T., Mei, J., Ho, J. J., Zhang, W., Lopez, P., and Ho, D. D. Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor. Science (Wash. DC), 298: 995-1000, 2002.
20. Dobryszycka, W. Biological functions of haptoglobin-new pieces to an old puzzle. Eur. J. Clin. Chem. Clin. Biochem., 35: 647-654, 1997.
21. Dobryszycka, W. Unending history of haptoglobin-the last five years. Postepy. Hig. Med. Dosw., 51: 243-268, 1997.
22. Bowman, B. H., and Kurosky, A. Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation. Adv. Hum. Genet., 12: 189-261, 453-184, 1982.
23. Langlois, M. R., and Delanghe, J. R. Biological and clinical significance of haptoglobin polymorphism in humans. Clin. Chem., 42: 1589-1600, 1996.
24. Harvey, S. R., Nayak, S. K., Markus, G., Ouhammouch, M., Hemperly, J. J., Dillman, R. O., and Doyle, D. J. Cancer cells release a covalent complex containing disulfide-linked domains from urinary plasminogen activator, neural cell adhesion molecule, and haptoglobin alpha and beta chains. Arch. Biochem. Biophys., 345: 289-298, 1997.
25. Piva, M., Horowitz, G. M., and Sharpe-Timms, K. L. Interleukin-6 differentially stimulates haptoglobin production by peritoneal and endometriotic cells in vitro: a model for endometrial-peritoneal interaction in endometriosis. J. Clin. Endocrinol. Metab., 86: 2553-2561, 2001.
26. Xie, Y., Li, Y., Zhang, Q., Stiller, M. J., Wang, C. L., and Streilein, J. W. Haptoglobin is a natural regulator of Langerhans cell function in the skin. J. Dermatol. Sci., 24: 25-37, 2000.
27. Oh, S. K., Very, D. L., Walker, J., Raam, S., and Ju, S. T. An analogy between fetal haptoglobin and a potent immunosuppressant in cancer. Cancer Res., 47: 5120-5126, 1987.
28. Oh, S. K., Kim, S. H., and Walker, J. E. Interference with immune response at the level of generating effector cells by tumor-associated haptoglobin. J. Natl. Cancer Inst. (Bethesda), 82: 934-940, 1990.
29. Cid, M. C., Grant, D. S., Hoffman, G. S., Auerbach, R., Fauci, A. S., and Kleinman, H. K. Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis. J. Clin. Investig., 91: 977-985, 1993.
30. Fish, R. G., Gill, T. S., Adams, M., and Kerby, I. Serum haptoglobin and alpha 1-acid glycoprotein as indicators of the effectiveness of cis-diamminedichloroplatinum (CDDP) in ovarian cancer patients - a preliminary report. Eur. J. Cancer Clin. Oncol., 20: 625-630, 1984.
31. Thompson, S., Dargan, E., and Turner, G. A. Increased fucosylation and other carbohydrate changes in haptoglobin in ovarian cancer. Cancer Lett., 66: 43-48, 1992.
32. Black, J. A., and Dixon, G. H. Amino-acid sequence of alpha chains of human haptoglobins. Nature (Lond.), 218: 736-741, 1968.
33. Kristiansen, M., Graversen, J. H., Jacobsen, C., Sonne, O., Hoffman, H. J., Law, S. K., and Moestrup, S. K. Identification of the haemoglobin scavenger receptor. Nature (Lond.), 409: 198-201, 2001.