2,3,4,5-Tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: New templates for 5-HT2C agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 14, 2003, Pages 2369-2372

  Ennis, Michael D ^a   Hoffman, Robert L ^a   Ghazal, Nabil B ^a   Olson, Rebecca M ^a   Knauer, Christopher S ^a   Chio, Chris L ^a   Hyslop, Deborah K ^a   Campbell, Jeffery E ^a   Fitzgerald, Lawrence W ^a   Nichols, Nanette F ^a   Svensson, Kjell A ^a   McCall, Robert B ^a   Haber, Christopher L ^a   Kagey, Michelle L ^a   Dinh, Dac M ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,5 TETRAHYDRO 1H [1,4]DIAZEPIN[1,7 A]INDOLE; 2,3,4,5,11,11A HEXAHYDRO 1H [1,4]DIAZEPIN[1,7 A]INDOLE; INDOLE DERIVATIVE; SEROTONIN 2C ANTAGONIST; UNCLASSIFIED DRUG;

AGGRESSION; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DRUG SELECTIVITY; DRUG SYNTHESIS; MOUSE; NONHUMAN; SHOCK;

EID: 12444299610     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00403-7     Document Type: Article

References (14)

1. (a) Isaac M. Drugs Future. 26:2001;383
2. (b) Roth B.L., Shapiro D.A. Exp. Opin. Ther. Targets. 5:2001;685.
3. Fitzgerald L.W., Ennis M.D. Annu. Rep. Med. Chem. 37:2002;21.
4. Hester J.B., Tang A.H., Keasling H.H., Veldkamp W. J. Med. Chem. 11:1968;101.
5. (a) Gallant D.M., Bishop M.P., Bishop G., O'Meallie L. Curr. Therapeutic Res. 9:1967;579
6. Nichols, N. F.; Sobie, J. L.; Cimini, M. G.; Kagey, M. L.; Haber, C. L.; Svensson, K. A. Abstracts of Papers, 32 Annual Meeting of the Society for Neuroscience, Orlando, Fl, 2002; 290.13.
7. (a) Bos M., Jenck F., Martin J.R., Moreau J.-L., Sleight A.J., Wichmann J., Widmer U. J. Med. Chem. 40:1997;2762
8. (b) Chang-Fong J., Addo J., Dukat M., Smith C., Mitchell N.A., Herrick-Davis K., Teitler M., Glennon R.A. Bioorg. Med. Chem. Lett. 12:2002;155.
9. Moody C.J., Rahimtoola K.F. J. Chem. Soc., Perkin Trans. I. 1990;673.
10. 2+) with fluorescence readings taken 10 s before and 4 min after the agonist addition.
11. Robichaud; A. J.; Chen; W.; McClung; C.; Stranz; M.; Clark; D.; Deng; W.; Calvello; E. B.; Mitchell; I. S.; Lee; T.; Rajagopalan; P.; Robertson; D. W.; Molino; B. F.; Haydar; S. N.; Conlon; M. P.; Duffy; B. C.; Liao; J.; Pawlush; N. G.; Fitzgerald; L. W.; Conklin; D. S.; Krause; C. M.; McElroy; J. F.; Rohrbach; K. W.; Miller K. J.; Largent; B. L. Abstracts of Papers; 221 National Meeting of the American Chemical Society; San Diego; CA; 2001; MEDI-105.
12. Ennis M.D., Hoffman R.L., Ghazal N.B., Olson R.M. WO0172752, 2001; Chem. Abstr. 135:2001;288799.
13. Littke A.F., Fu G.C. Angew. Chem. Int. Ed. Eng. 37:1998;3387.
14. Abe M., Nakai H., Tabata R., Saito K.-I., Egawa M. Jpn. J. Pharm. 76:1998;297.