Evaluation of serum KL-6 as a predictive marker of radiation pneumonitis in patients with breast-conservation therapy

International Journal of Clinical Oncology

Volumn 9, Issue 6, 2004, Pages 498-502

  Tokiya, Ryoji ^a   Hiratsuka, Junichi ^a   Yoshida, Kenji ^a   Imai, Shigeki ^a   Kajihara, Yasumasa ^a   Imajo, Yoshinari ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

Breast cancer; Breast conservation therapy; Radiation pneumonitis; Serum KL 6

Indexed keywords

BIOLOGICAL MARKER; GLYCOPROTEIN; GLYCOPROTEIN KL 6; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BEAM THERAPY; BREAST CANCER; BREAST SURGERY; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; ORGAN PRESERVATION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION PNEUMONIA; TUMOR CELL; X RAY;

ADULT; AGED; ANTIGENS; ANTIGENS, NEOPLASM; BIOLOGICAL MARKERS; BREAST NEOPLASMS; FEMALE; GLYCOPROTEINS; HUMANS; MASTECTOMY, SEGMENTAL; MIDDLE AGED; MUCINS; PREDICTIVE VALUE OF TESTS; RADIATION PNEUMONITIS; SENSITIVITY AND SPECIFICITY;

EID: 12444292158     PISSN: 13419625     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10147-004-0438-9     Document Type: Article

References (17)

1. Lingons TI, Recht A, Vicini F, et al. (1991) Radiation pneumonitis in breast cancer treated with conservative surgery and radiation therapy. Int J Radiat Oncol Biol Phys 21:355-360
2. th Annual Meeting of the Society for Therapeutic Radiology and Oncology. Refresher course. No. 403, Philadelphia, USA
3. Movsas B, Raffin TA, Epstein AH, et al. (1997) Pulmonary radiation injury. Chest 111:1061-1076
4. Kohno N, Akiyama M, Kyoizumi S, et al. (1988) Detection of soluble tumor-associated antigens in sera and effusion using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma. Jpn J Clin Oncol 18:203-216
5. Stahel RA, Gilks WR, Lehmann HP, et al. (1994) Third international workshop on lung tumor and differentiation antigens: overview of the results of the central data analysis. Int J Cancer (Suppl 8):s6-s26
6. Yokoyama A, Kohno N, Kondo K, et al. (1998) Comparative evaluation of sialylated carbohydrate antigens, KL-6, CA19-9, and SLX as serum markers for interstitial pneumonia. Respirology 3:199-202
7. Kohno N, Kyoizumi S, Awaya Y, et al. (1989) New serum indicator of interstitial pneumonitis activity: sialylated carbohydrate antigen KL-6. Chest 96:68-73
8. Ohnishi H, Yokoyama A, Kondo K, et al. (2002) Comparative study of KL-6, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung Diseases. Am J Respir Crit Care Med 165:378-381
9. Kohno N, Yokoyama A, Hirasawa Y, et al. (1997) Comparative studies of circulating KL-6. type III procollagen N-terminal peptide and type IV collagen 7S in patients with interstitial pneumonitis and alveolar pneumonia. Respir Med 91:558-561
10. Goto K, Kodama T, Sekine I, et al. (2001) Serum levels of KL-6 are useful biomarkers for severe radiation pneumonitis. Lung Cancer 34:141-148
11. American Joint Committee on Cancer (1992) Manual for staging of cancer, 4th edn. Philadelphia PA, Lippincott, pp 149-154
12. Trotti A, Byhardt R, Stetz J, et al. (2000) Common toxicity criteria: version 2.0. An improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int J Radiat Oncol Biol Phys 47:13-47
13. Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495-497
14. Imaizumi TA, Albertine KH, Jicha DL, et al. (1997) Human endothelial cells differentially express and secrete ENA-78 and IL-8 when stimulated with inflammatory cytokines. Am J Respir Cell Mol Biol 17:181-192
15. Kohno N, Hamada H, Fujioka S, et al. (1992) Circulating antigen KL-6 and lactate dehydrogenase for monitoring irradiated patients with lung cancer. Chest 102:117-122
16. Ogawa Y, Ishikawa T, Ikeda K, et al. (2000) Evaluation of serum KL-6, a mucin-like glycoprotein, as a tumor marker for breast cancer. Clin Cancer Res 6:4069-4072
17. Taghian AG, Assaad SI, Niemierko A, et al. (2001) Risk of pneumonitis in breast cancer patients treated with radiation therapy and combination chemotherapy with paclitaxel. J Natl Cancer Inst 93:1806-1811