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Volumn 36, Issue 6, 2004, Pages 587-596

Kilogram-scale synthesis of bis(6-hydroxy-5, 5-dimethylhexyl)ether (esp24232), a novel lipid lowering agent

Author keywords

[No Author keywords available]

Indexed keywords

LIPID LOWERING;

EID: 12444292070     PISSN: 00304948     EISSN: 19455453     Source Type: Journal    
DOI: 10.1080/00304940409355976     Document Type: Article
Times cited : (3)

References (18)
  • 1
    • 85023471345 scopus 로고    scopus 로고
    • US Patent 6, 410, 802, March 31, 2000;
    • J.-L. H. Dasseux and D. C. Oniciu, US Patent 6, 410, 802, March 31, 2000; Chem. Abstr., 136, 30993 lu (2002).
    • (2002) Chem. Abstr. , vol.136
    • Dasseux, J.-L.H.1    Oniciu, D.C.2
  • 2
    • 85023459846 scopus 로고    scopus 로고
    • US Patent 6, 459, 003, March 31, 2000;
    • J.-L. H. Dasseux and D. C. Oniciu, US Patent 6, 459, 003, March 31, 2000; Chem. Abstr., 133, 291122g (2000).
    • (2000) Chem. Abstr. , vol.133 , pp. 291
    • Dasseux, J.-L.H.1    Oniciu, D.C.2
  • 5
    • 85023435551 scopus 로고    scopus 로고
    • WO 9900116 A2, 1999
    • J. Bar-Tana, WO 9900116 A2, 1999; Chem. Abstr., 130, 105306k (1999).
    • (1999) Chem. Abstr. , vol.130 , pp. 105-306
    • Bar-Tana, J.1
  • 13
    • 0030985372 scopus 로고    scopus 로고
    • reaction of ethyl isobutyrate with LDA and 1, 4-dibromobutane in THF, first at -78°C and then at room temperature, afforded ethyl 6-bromo-2, 2-dimethylhexanoate in 98% yield after distillation. It is assumed that a large excess of 1, 4-dibromobutane was used in this reaction
    • M. Kuwahara, Y. Kawano, M. Kajino, Y. Ashida and A. Miyake, [ chem. Pharm. Bull., 45, 1447 (1997)], reaction of ethyl isobutyrate with LDA and 1, 4-dibromobutane in THF, first at -78°C and then at room temperature, afforded ethyl 6-bromo-2, 2-dimethylhexanoate in 98% yield after distillation. It is assumed that a large excess of 1, 4-dibromobutane was used in this reaction.
    • (1997) [ Chem. Pharm. Bull. , vol.45 , pp. 1447
    • Kuwahara, M.1    Kawano, Y.2    Kajino, M.3    Ashida, Y.4    Miyake, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.