Cytokine-receptor pairing: Accelerating discovery of cytokine function

Nature Reviews Drug Discovery

Volumn 3, Issue 2, 2004, Pages 160-170

  Foster, Don ^a   Parrish Novak, Julia ^a   Fox, Brian ^a   Xu, Wenfeng ^a  

^a ZYMOGENETICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1A INTERFERON; CILIARY NEUROTROPHIC FACTOR; CYTOKINE; CYTOKINE RECEPTOR; ETANERCEPT; GAMMA1B INTERFERON; HUMAN GROWTH HORMONE; IMMUNOGLOBULIN; INFLIXIMAB; INSULIN LISPRO; INTERFERON BETA SERINE; INTERLEUKIN 10; INTERLEUKIN 19; INTERLEUKIN 20; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 24; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; LIGAND; MONOCLONAL ANTIBODY; PEGINTERFERON ALPHA2B; RECOMBINANT ALPHA2B INTERFERON; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 11; RECOMBINANT INTERLEUKIN 2; RITUXIMAB; SOMATREM; THROMBOPOIETIN; UNINDEXED DRUG;

CANCER; CLINICAL TRIAL; CROHN DISEASE; DRUG ACTIVITY; DRUG MARKETING; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; EXPRESSED SEQUENCE TAG; GENE THERAPY; HEPATITIS C; HUMAN; NEUROPATHY; NIDATION; NONHUMAN; OBESITY; PARALOGY; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; RHEUMATOID ARTHRITIS; SEQUENCE ANALYSIS; SEQUENCE DATABASE; SEQUENCE HOMOLOGY; SYSTEMIC LUPUS ERYTHEMATOSUS; TISSUE DISTRIBUTION;

EID: 1242353136     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd1305     Document Type: Review

References (100)

1. Boulay, J.-L., O'Shea, J. J. & Paul, W. E. Molecular phylogeny within type I cytokines and their cognate receptors. Immunity 19, 150-163 (2003).
2. Renauld, J.-C. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators. Nature Rev. Immunol. 3, 667-676 (2003).
3. Xu, W. et al. A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc. Natl Acad. Sci. USA 98, 9511-9516 (2001).
4. Dumoutier, L., Lejeune, D., Colau, D. & Renauld, J.-C. Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J. Immunol. 166, 7090-7095 (2001).
5. Kotenko, S. V. et al. Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. J. Immunol. 166, 7096-7103 (2001).
6. Borish, L. C. et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J. Allergy Clin. Immunol. 107, 963-970 (2001).
7. Grünig, G. et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282, 2261-2263 (1998).
8. Fernandez-Botran, R. Soluble cytokine receptors: novel immunotherapeutic agents. Exp. Opin. Invest. Drugs 9, 497-514 (2000).
9. Simonet, W. S. et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89, 309-319 (1997).
10. Gross, J. A. et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 404, 995-999 (2000).
11. Thompson, J. S. et al. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293, 2108-2111 (2001).
12. Kary, S. & Burmester, G. R. Anakinra: the first interleukin-1 inhibitor in the treatment of rheumatoid arthritis. Int. J. Clin. Pract. 57, 231-234 (2003).
13. Dinarello, C.A. Interleukin-18, a proinflammatory cytokine. Eur. Cytokine Netw. 11, 483-486 (2000).
14. Rozwarski, D. A. et al. Structural comparisons among the short-chain helical cytokines. Structure 2, 159-173 (1994).
15. Wiley, S. R. et al. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity 15, 837-846 (2001).
16. Cosman, D. A family of ligands for the TNF receptor superfamily. Stem Cells 12, 440-455 (1994).
17. Bazan, J. F. Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl Acad. Sci. USA 87, 6934-6938 (1990).
18. Pennica, D. et al. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc. Natl Acad. Sci. USA 92, 1142-1146 (1995).
19. Chen, Q. et al. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407, 916-920 (2000).
20. + T cells. Immunity 16, 779-790 (2002).
21. Knappe, A., Hör, S., Wittmann, S. & Fickenscher, H. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with Herpesvirus saimiri. J. Virol. 74, 3881-3887 (2000).
22. Parrish-Novak, J. et al. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. J. Biol. Chem. 277, 47517-47523 (2002).
23. Kotenko, S. V. The family of IL-10-related cytokines and their receptors: related, but to what extent? Cytokine Growth Factor Rev 13, 233-240 (2002).
24. Cosman, D. et al. Cloning, sequence and expression of human interleukin-2 receptor. Nature 312, 768-771 (1984).
25. Leonard, W. J. et al. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 311, 626-631 (1984).
26. Leung, D. W. et al. Growth hormone receptor and serum binding protein: purification, cloning, and expression. Nature 330, 537-543 (1987).
27. D'Andrea, A. D., Lodish, H. F. & Wong, G. G. Expression cloning of the murine erythropoietin receptor. Cell 57, 277-285 (1989).
28. Gearing, D. P., King, J. A., Gough, N. M. & Nicola, N. A. Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J. 8, 3667-3676 (1989).
29. Harada, N. et al. Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding. Proc. Natl Acad. Sci. USA 87, 857-861 (1990).
30. Takaki, S. et al. Molecular cloning and expression of the murine interleukin-5 receptor EMBO J. 9, 4367-4374 (1990).
31. Yamasaki, K. et al. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor Science 241, 825-828 (1988).
32. Goodwin, R. G. et al. Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 60, 941-951 (1990).
33. Yang, Y. C. et al. Human IL-3 (multi-CSF)- identification by expression cloning of a novel hematopoietic growth-factor related to murine IL-3. Cell 47, 3-10 (1986).
34. Wong, G. G. et al. Human GM-CSF: molecular cloning of the complementary-DNA and purification of the natural and recombinant proteins. Science 228, 810-815 (1985).
35. Davis, S. et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secreton-trap expression cloning. Cell 87, 1161-1169 (1996).
36. Wendling, F., Varlet, P., Charon, M. & Tambourin, P. MPLV: a retrovirus complex inducing an acute myeloproliferative leukemic disorder in adult mice. Virology 149, 242-246 (1986).
37. Souyri, M. et al. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63, 1137-1147 (1990).
38. Vigon, I. et al. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc. Natl Acad. Sci. USA 89, 5640-5644 (1992).
39. Methia, N., Louache, F., Vainchenker, W. & Wendling, F. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 82, 1395-1401 (1993).
40. Skoda, R. C. et al. Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J. 12, 2645-2653 (1993).
41. Bartley, T. D. et al. identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77, 1117-1124 (1994).
42. de Sauvage, F. J. et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369, 533-538 (1994).
43. Lok, S. et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369, 565-568 (1994).
44. Kaushansky, K. et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369, 568-571 (1994).
45. Kelemen, E., Scerhati, I. & Tanos, B. Demonstration and some properties of human thrombopoietin in thrombocythaemic sera. Acta Haematol. 20, 350-355 (1958).
46. Ozaki, K., Kikly, K., Michalovich, D., Young, P. R. & Leonard, W. J. Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain. Proc. Natl Acad. Sci. USA 97, 11439-11444 (2000).
47. Parrish-Novak, J. et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408, 57-63 (2000).
48. Asao, H. et al. Cutting edge: the common γ-chain is an indispensible subunit of the IL-21 receptor complex. J. Immunol. 167, 1-5 (2001).
49. Habib, T., Weinberg, K. & Kaushansky, K. The common γ chain (γc) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3. Biochemistry 41, 8725-8731 (2002).
50. Nelson, A. et al. Anti-tumor effects of interleukin 21. Blood 100, A158 (2002).
51. Moore, P. A. et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 285, 206-263 (1999).
52. Schneider, P. et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med. 189, 1747-1756 (1999).
53. Hahne, M. et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates cell growth. J. Exp. Med. 188, 1185-1190 (1998).
54. Ware, C. F. APRIL and BAFF connect autoimmunity and cancer. J. Exp. Med. 192, F35-F37 (2000).
55. von Bülow, G.-U. & Bram, R. J. NF-AT activation by a CAML-interacting member of the tumor necrosis factor receptor superfamily. Science 278, 138-141 (1997).
56. Laâbi, Y. et al. A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma. EMBO J. 11, 3897-3904 (1992).
57. Gross, J. A. et al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease: impaired B cell maturation in mice lacking BLyS. Immunity 15, 289-302 (2001).
58. Marsters, S. A. et al. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr. Biol. 10, 785-788 (2000).
59. von Bülow, G.-U., van Deursen, J. M. & Bram, R. J. Regulation of the T-independent humoral response by TACI. Immunity 14, 573-582 (2001).
60. Yan, M. et al. Activation and accumulation of B cells in TACI-deficient mice. Nature Immunol. 2, 638-643 (2001).
61. Xu, S. & Lam, K.-P. B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Mol. Cell. Biol. 21, 4067-4074 (2001).
62. Yan, M. et al. Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr. Biol. 11, 1547-1552 (2001).
63. Moore, K. W., de Waal Malefyt, R., Coffman, R. L. & O'Garra, A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19, 683-765 (2001).
64. Gallagher, G. et al. Cloning, expression, and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10). Genes Immun. 1, 442-450 (2000).
65. Blumberg, H. et al. Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell 104, 9-19 (2001).
66. Dumoutier, L., Louahed, J. & Renauld, J.-C. Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-19. J. Immunol. 164, 1814-1819 (2000).
67. Jiang, H., Lin, J. J., Su, Z. Z., Goldstein, N. I. & Fisher, P. B. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 11, 2477-2486 (1995).
68. Kotenko, S. V. et al. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. EMBO J. 16, 5894-5903 (1997).
69. Dumoutier, L. et al. Cutting Edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J. Immunol. 167, 3545-3549 (2001).
70. Xie, M.-H. et al. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor related proteins CRF2-4 and IL-22R. J. Biol. Chem. 275, 31335-31339 (2000).
71. Aggarwal, S., Xie, M. H., Maruoka, M., Foster, J. & Gurney, A. L. Acinar cells of the pancreas are a target of interleukin-22. J. Interferon Cytokine Res. 21, 1047-1053 (2001).
72. Wolk, K., Kunz, S., Asadullah, K. & Sabat, R. Cutting Edge: immune cells as sources and targets of the IL-10 family members? J. Immunol. 168, 5397-5402 (2002).
73. Ghilardi, N. et al. A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. J. Biol. Chem. 277, 16831-16836 (2002).
74. Sprecher, C. A. et al. Cloning and characterization of a novel class I cytokine receptor. Biochem. Biophys. Res. Comm. 246, 82-90 (1998).
75. Rennert, P. et al. A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth. J. Exp. Med. 192, 1677-1683 (2000).
76. Pan, G. et al. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 431, 351-356 (1998).
77. + T cell proliferation and Th2 cytokine production in DR6-deficient mice. Immunity 15, 23-34 (2001).
78. Schmidt, C. S. et al. Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6. J. Exp. Med. 197, 51-62 (2003).
79. Zhao, H. et al. Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice. J. Exp. Med. 194, 1441-1448 (2001).
80. Kojima, T. et al. TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. J. Biol. Chem. 275, 20742-20747 (2000).
81. Hu, S., Tamada, K., Ni, J., Vincenz, C. & Chen, L. Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily. Genomics 62, 103-107 (1999).
82. Sica, G. L. et al. RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-κB. Blood 97, 2702-2707 (2001).
83. Li, H. et al. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 family. Proc. Natl Acad. Sci. USA 97, 773-778 (2000).
84. Aggarwal, S. & Gurney, A. L. IL-17: prototype member of an emerging cytokine family. J. Leukoc. Biol. 71, 1-8 (2002).
85. H2 responses in the lung: in vivo function of the novel cytokine IL-25. J. Immunol. 169, 443-453 (2002).
86. Kawaguchi, M. et al. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. J. Immunol. 167, 4430-4435 (2001).
87. H2-biased response, and multiorgan inflammation in mice. J. Immunol. 167, 6559-6567 (2001).
88. Lee, J. et al. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J. Biol. Chem. 276, 1660-1664 (2001).
89. Shi, Y. et al. A novel cytokine receptor ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. J. Biol. Chem. 275, 19167-19176 (2000).
90. Yang, R.-B. et al. A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor induced signaling. J. Biol. Chem. 278, 33232-33238 (2003).
91. Zhu, Y. et al. Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics 80, 144-150 (2002).
92. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. Basic local alignment search tool. J. Mol. Biol. 215, 403-410 (1990).
93. Altschul, S. F. et al. Gapped BLAST and PSI-BLAST. a new generation of protein database search programs. Nucl. Acids Res. 25, 3389-3402 (1997).
94. Sonnhammer, E. L., Eddy, S. R., Birney, E., Bateman, A. & Durbin, R. Pfam: multiple sequence alignments and HMM-profiles of protein domains. Nucl. Acids Res. 26, 320-322 (1998).
95. Jaroszewski, L., Rychlewski, L., Zhang, B. & Godzik, A. Fold prediction by a hierarchy of sequence, threading, and modeling methods. Protein Sci. 7, 1431-1440 (1998).
96. Aloy, P., Stark, A., Hadley, C. & Russell, R. B. Predictions without templates: new folds, secondary structure, and contacts in CASP5. Proteins 53 (Suppl. 6), 436-456 (2003).
97. Burge, C. & Karlin, S. Prediction of complete gene structures in human genomic DNA. J. Mol. Biol. 268, 78-94 (1997).
98. Hubbard, T. et al. The Ensembi genome database project. Nucl. Acids Res. 30, 38-41 (2002).
99. Bono, H., Kasukawa, T., Furuno, M., Hayashizaki, Y. & Okazaki, Y. FANTOM DB: database of functional annotation of RIKEN mouse cDNA clones. Nucl. Acids Res. 30, 116-118 (2002).
100. Bibby, K., Davis, J. & Jones, C. Biopharmaceuticals - moving to centre stage. BioPeople North American Biotechnology Industry and Suppliers' Guide, IMS Global Consulting (2003).