The COSTIM bioassay: A novel potency test for dendritic cells

Journal of Immunological Methods

Volumn 285, Issue 2, 2004, Pages 293-299

  Shankar, Gopi ^a,b   Bader, Robert ^a   Lodge, Patricia A ^a  

^a Northwest Biotherapeutics Inc   (United States)

^b CENTOCOR INC   (United States)

Author keywords

Bioassay; Co stimulation; Dendritic cells; Potency; Quality control

Indexed keywords

ANTIGEN PRESENTING CELL; ARTICLE; BIOASSAY; CELL CULTURE; CELL FUNCTION; CELL STIMULATION; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; IMMUNOTHERAPY; IN VITRO STUDY; MEASUREMENT; PRIORITY JOURNAL; QUALITY CONTROL;

EID: 1242351226     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2003.12.008     Document Type: Article

References (4)

1. U.S. Code of Federal Regulations. 21 CFR 600.3(s). U.S. Government Printing Office, Washington, DC, USA.
2. Monji T., Smits-Sana B., Qian L., Stark L., Therond J., Shiomoto C., Peshwa M.V. Development of assay for assessment of dendritic cell product potency. International Society for Hematotherapy and Graft Engineering (ISHAGE) 2000, San Diego, CA. 2000;. Abstract 139.
3. Steinman R.M., Witmer M.D. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc. Natl. Acad. Sci. U. S. A. 75:1978;5132-5136.
4. Van Voorhis W.C., Valinsky J., Hoffman E., Luban J., Hair L.S., Steinman R.M. Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication. J. Exp. Med. 158:1983;174-191.