Hexachlorobenzene

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

Volumn 79, Issue , 2001, Pages 493-568

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EID: 1242350293     PISSN: 02509555     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (257)

1. Abraham, K., Hille, A., Ende, M. & Helge, H. (1994) Intake and fecal excretion of PCDDs, PCDFs, HCB and PCBs (138, 153, 180) in a breast-fed and a formula-fed infant. Chemosphere, 29, 2279-2286
2. Agency for Toxic Substances and Disease Registry (1998) Toxicological Profile for Hexachlorobenzene, Atlanta, GA
3. Alawi, M.A. & Ababneh, M. (1991) Residue analysis of chlorinated pesticides in Jordanian human adipose tissue. Anal. Lett., 25, 1897-1911
4. Alleman, M.A., Koster, J.F., Wilson, J.H.P., Edixhoven-Bosdijk, A., Slee, R.G., Kroos, M.J. & Eijk, H.GV. (1985) The involvement of iron and lipid peroxidation in the pathogenesis of HCB induced porphyria. Biochem. Pharmacol., 34, 161-166
5. Almeida, M.G., Fanini, S.C., Davino, S.C., Aznar, A.E., Koch, O.R. & Barros, S.B. (1997) Proand anti-oxidant parameters in rat liver after short term exposure to hexachlorobenzene. Hum. exp. Toxicol, 16, 257-261
6. Alvarez, L., Randi, A., Alvarez, P., Kolliker Frers, R. & Kleiman de Pisarev, D.L. (1999) Effect of hexachlorobenzene on NADPH-generating lipogenic enzymes and L-glycerol-3-phosphate dehydrogenase in brown adipose tissue. J. endocrinol. Invest., 22, 436-445
7. Alvarez, L., Randi, A., Alvarez, P., Piroli, G., Chamson-Reig, A., Lux-Lanso, V. & Kleiman de Pisarev, D. (2000) Reproductive effects of hexachlorobenzene in female rats. J. appl. Toxicol., 20, 81-87
8. American Conference of Governmental Industrial Hygienists (2000) TLVs and other Occupational Exposure Values 2000 [CD-ROM], Cincinnati, OH
9. American Public Health Association/American Water Works Association/Water Environment Federation (1999a) Method 6040B. Closed-loop stripping, gas chromatographic/mass spectrometric analysis. In: Standard Methods for the Examination of Water and Wastewater, 20th Ed., Washington DC
10. American Public Health Association/American Water Works Association/Water Environment Federation (1999b) Method 641 OB. Liquid-liquid extraction gas chromatographic/mass spectrometric method. In: Standard Methods for the Examination of Water and Wastewater, 20th Ed., Washington DC
11. Ando, M., Hirano, S. & Itoh, Y. (1985) Transfer of hexachlorobenzene (HCB) from mother to new-born baby through placenta and milk. Arch. Toxicol., 56, 195-200
12. Andrews, J.E. & Courtney, K.D. (1986) Hexachlorobenzene-induced renal maldevelopment in CD-1 mice and CD rats. In: Morris, C.R. & Cabrai, J.R.P., eds, Hexachlorobenzene: Proceedings of an International Symposium (IARC Scientific Publications No. 77), Lyon, IARCPress, pp. 381-391
13. Andrews, J.E., Courtney, K.D. & Donaldson, W.E. (1988) Impairment of calcium homeostasis by hexachlorobenzene (HCB) exposure in Fischer 344 rats. J. Toxicol. environ. Health, 23, 311-320
14. Andrews, J.E., Courtney, K.D., Stead, A.G & Donaldson, W.E. (1989) Hexachlorobenzeneinduced hyperparathyroidism and osteosclerosis in rats. Fundam. appl. Toxicol., 12, 242-251
15. Andrews, J.E., Jackson, L.D., Stead, A.G & Donaldson, W.E. (1990) Morphometric analysis of osteosclerotic bone resulting from hexachlorobenzene exposure. J. Toxicol. environ. Health, 31, 193-201
16. AOAC International (2000) Official Methods of Analysis of AOAC International, 17th Ed., Gaithersburg, MD [CD-ROM] [Methods 977.19, 980.22, 999.04]
17. Arnold, D.L. & Krewski, D. (1988) Long-term toxicity of hexachlorobenzene (Letter to the Editor). Foodchem. Toxicol., 26, 169-174
18. Arnold, D.L., Moodie, C.A., Charbonneau, S.M., Grice, H.C., McGuire, P.P., Bryce, F.R., Coliins, B.T., Zawidzka, Z.Z., Krewski, D.R., Nera, E.A. & Munro, C.I. (1985) Long-term toxicity of hexachlorobenzene in the rat and the effect of dietary vitamin A. Food chem. Toxicol., 23, 779-793
19. Aronson, K.J., Miller, A.B., Woolcott, C.G., Sterns, E.E., McCready, D.R., Lickley, L.A., Fish, E.B., Hiraki, G.Y., Holloway, C., Ross, T., Hanna, W.H., SenGupta, S.K. & Weber, J.P. (2000) Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk. Cancer Epidemiol. Biomarkers Prev., 9, 55-63
20. Bailey, J., Knauf, V., Mueller, W. & Hobson, W. (1980) Transfer of hexachlorobenzene and polychlorinated biphenyls to nursing infant rhesus monkeys: Enhanced toxicity. Environ. Res., 21, 190-196
21. Barnett, J.B., Barfield, L., Walls, R., Joyner, R., Owens, R. & Soderberg, L.S. (1987) The effect of in utero exposure to hexachlorobenzene on the developing immune response of BALB/c mice. Toxicol. Lett., 39, 263-274
22. den Besten, C., Bennik, M., Bruggeman, I., Schielen, P., Kuper, F., Brouwer A., Koeman, J.H., Vos, J.G & van Bladeren, P.J. (1993) The role of oxidative metabolism in hexachlorobenzene-induced porphyria and thyroid hormone homeostasis: A comparison with pentachlorobenzene in a 13-week feeding study. Toxicol. appl. Pharmacol., 119, 181-194
23. den Besten, C., Bennik, M., van lersel, M., Peters, M.A., Teunis, C. & van Bladeren, P.J. (1994) Comparison of the urinary metabolite profiles of hexachlorobenzene and pentachlorobenzene in the rat. Chem.-biol. Interactions, 90, 121-137
24. Billi de Catabbi, S., Koss, G & San Martin de Viale, L.C. (1986) Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylase. Res. Commun, chem. Pathol. Pharmacol., 51, 325-336
25. Billi de Catabbi, S., Sterin-Speziale, N., Fernandez, M.C., Minutolo, C., Aldonatti, C. & San Martin de Viale, L. (1997) Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria. Int. J. Biochem. Cell Biol., 29, 335-344
26. Billings, W.N. & Bidleman, T.F. (1980) Field comparison of polyurethane foam and Tenax-GC resin for high-volume air sampling of chlorinated hydrocarbons. Environ. Sci. Technol., 14, 679-683
27. Bleavins, M.R., Bursian, S.J., Brewster, J.S. & Aulerich, R.J. (1984) Effects of dietary hexachlorobenzene exposure on regional brain biogenic amine concentrations in mink and European ferrets. J. Toxicol. environ. Health, 14, 363-377
28. Booth, N.H. & McDowell, J.R. (1975) Toxicity of hexachlorobenzene and associated residues in edible animal tissues. J. Am. vet. med. Assoc., 166, 591-595
29. Bouthillier, L., Greselin, E., Brodeur, J., Viau, C. & Charbonneau, M. (1991) Male rat specific nephrotoxicity resulting from subchronic administration of hexachlorobenzene. Toxicol. appl. Pharmacol., 110, 315-326
30. Bristol, D.W., Grist, H.L., Lewis, R.G., MacLeod, K.E. & Sovocool, GW. (1982) Chemical analysis of human blood for assessment of environmental exposure to semivolatile organochlorine chemical contaminants. J. anal. Toxicol., 6, 269-275
31. Brusick, D.J. (1986) Genotoxicity of hexachlorobenzene and other chlorinated benzenes. In: Morris, C.R. & Cabrai, J.R.P., eds, Hexachlorobenzene: Proceedings of an International Symposium (IARC Scientific Publications No. 77), Lyon, IARCPress, pp. 393-397
32. Budavari, S., ed. (2000) The Merck Index, 12th Ed., Version 12:3, Whitehouse Station, NJ, Merck & Co. & Boca Raton, FL, Chapman & HalI/CRC[CD-ROM]
33. Burns, J.E. & Miller, P.M. (1975) Hexachlorobenzene contamination: Its effects in a Louisiana population. Arch, environ. Health, 30, 44-48
34. Burse, W.W., Head, S.L., Korver, M.P., McClure, P.C., Donahue, J.F. & Needham, L.L. (1990) Determination of selected organochlorine pesticides and polychlorinated biphenyls in human serum. J. anal. Toxicol, 14, 137-142
35. Cabrai, J.R. & Shubik, P. (1986) Carcinogenic activity of hexachlorobenzene in mice and hamsters. In: Morris, C.R. & Cabrai, J.R.P., eds, Hexachlorobenzene: Proceedings of an International Symposium (IARC Scientific Publications No. 77), Lyon, IARCPress, pp. 411-16
36. Cabrai, J.R.P., Shubik, P., Mollner, T. & Raitano, F. (1977) Carcinogenic activity of hexachlorobenzene in hamsters. Nature, 269, 510-511
37. Cabrai, J.R.P., Mollner, T., Raitano, F. & Shubik, P. (1979) Carcinogenesis of hexachlorobenzene in mice. Int. J. Cancer, 23, 47-51
38. Cabrai, R., Hoshiya, T., Hakoi, K., Hasegawa, R. & Ito, N. (1996) Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene. Cancer Lett., 100, 223-226
39. Cam, C. (1960) [A new epidemic dermatosis of children.] Ann. Derm. Syph., 87, 393-397 (in French)
40. Cam, C. & Nigogosyan, G. (1963) Acquired toxic porphyria cutanea tarda due to hexachlorobenzene. Report of 348 cases caused by this fungicide. J. Am. med. Assoc., 183, 88-91
41. Canonero, R., Campart, G.B., Mattioli, F., Robbiano, L. & Martelli, A. (1997) Testing ofp-dichlorobenzene and hexachlorobenzene for their ability to induce DNA damage and micronucleus formation in primary cultures of rat and human hepatocytes. Mutagenesis, 12, 35-39
42. Cantoni, L., Rizzardini, M., Tacconi, M.T. & Graziani, A. (1987) Comparison of hexachlorobenzene-induced alterations of microsomal membrane composition and monooxygenase activity in male and female rats. Toxicology, 45, 291-305
43. Carthew, P. & Smith, A.G (1994) Pathological mechanisms of hepatic tumor formation in rats exposed chronically to dietary hexachlorobenzene. J. appl. Toxicol., 14, 447-152
44. Carvalho, P.P., Montenegro-Guillen, S., Villeneuve, J.-P., Barticci, J., Lacayo, M. & Cruz, A. (1999) Chlorinated hydrocarbons in coastal lagoons of the Pacific coast of Nicaragua. Arch, environ. Contain. Toxicol., 36, 132-139
45. CIS Information Services (2000) Directory of World Chemical Producers (Version 2000.1), Dallas, TX [CD-ROM]
46. Cochon, A.C., San Martin de Viale, L.C. & Billi de Catabbi, S.C. (1999) Effects of hexachlorobenzene on phospholipid and porphyrin metabolism in Harderian glands: A time-course study in two strains of rats. Toxicol. Lett., 106, 129-136
47. Courtney, K.D. & Andrews, J.E. (1985) Neonatal and maternal body burdens of hexachlorobenzene (HCB) in mice: Gestational exposure and lactational transfer. Fundam. appl. Toxicol., 5, 265-277
48. Courtney, K.D., Andrews, J.E. & Svendsgaard, D.J. (1979) Hexachlorobenzene (HCB) deposition in maternal and fetal tissues of rat and mouse. 1. Chemical quantification of HCB in tissues. Environ. Res., 19, 1-13
49. Courtney, K.D., Andrews, J.E., Grady, M.A. & Ebron, M.T. (1984) Postnatal effects of hexachlorobenzene (HCB) on cardiac lactic dehydrogenase (LDH) and creatine kinase (CK) isozymes in CD-1 mice. Toxicol. Lett., 22, 223-228
50. Courtney, K.D., Andrews, J.E. & Grady, M.A. (1985) Placental transfer and fetal deposition of hexachlorobenzene in the hamster and guinea pig. Environ. Res., 37, 239-249
51. Cripps, D.J., Gocmen, A. & Peters, H.A. (1980) Porphyria turcica. Twenty years aüer hexachlorobenzene intoxication. Arch. Dermatol., 116, 46-50
52. Cripps, D.J., Peters, H.A., Gocmen, A. & Dogramici, I. (1984) Porphyria turcica due to hexachlorobenzene: A 20 and 30 year follow-up study on 204 patients. Br. J. Dermatol., Ill, 413-422
53. D'Amour, M. & Charbonneau, M. (1992) Sex-related difference in hepatic glutathione conjugation of hexachlorobenzene in the rat. Toxicol. appl. Pharmacol., 112, 229-234
54. Debets, F.M.H., Hamers, W.J.H.M.B. & Strik, J.J.T.W.A. (1980) Metabolism as a prerequisite for the porphyrinogenic action of polyhalogenated aromatics, with special reference to hexachlorobenzene and polybrominated biphenyls (Firemaster BP-6). Int. J. Biochem., 12, 1019-1025
55. Debets, F.M.H., Reinders, J.-H., Debets, A.J.M., Lossbroek, T.G., Strik, J.J.T.W.A. & Koss, G (1981a) Biotransformation and porphyrinogenic action of hexachlorobenzene and its metabolites in a primary liver cell culture. Toxicology, 19, 185-196
56. Debets, F.M.H., Reinders, J.-H., Koss, G., Seidel, J. & Strik, A. (1981 b) Effects of dietary antioxidants on the biotransformation and porphyrinogenic action of hexachlorobenzene in two strains of rats. Chem.-biol. Interactions, 37, 77-94
57. DeLeon, I.R., Maberry, M.A., Overton, E.B., Raschke, C.K., Remele, P.C., Steele, C.F., Warren, V.L. & Laseter, J.L. (1980) Rapid gas Chromatographie method for the determination of volatile and semivolatile organochlorine compounds in soil and chemical waste disposal site samples. J. chromatogr. Sci., 18, 85-88
58. Deutsche Forschungsgemeinschaft (2000) List ofMAK and BAT Values 1999 (Report No. 36), Weinheim, Wiley-VCH Verlag GmbH, pp. 64, 179
59. Dewailly, E., Dodin, S., Verreault, R., Ayotte, P., Sauvé, L., Morin, J. & Brisson, J. (1994) High organochlorine body burden in women with oestrogen receptor-positive breast cancer. J. natl Cancer Inst., 86, 232-234
60. Dewailly, E., Ayotte, P., Bruneau, S., Gingras, S., Bellels-Isles, M. & Roy, R. (2000) Susceptibility to infections and immune status to Inuit infants exposed to organochlorines. Environ. Health Perspect., 108, 205-211
61. Dienhart, M.K., Sommer, R.J., Peterson, R.E., Hirshfield, A.N. & Silbergeld, E.K. (2000) Gestational exposure to 2,3,7,8-tetrachlorodibenzo-/?-dioxin induces developmental defects in the rat vagina. Toxicol. Sci., 56, 141-149
62. Dorgan, J.F., Brock, J.W., Rothman, N., Needham, L.L., Miller, R., Stephenson, H.E., Schussler, N. & Taylor, P.R. (1999) Serum organochlorine pesticides and PCBs and breast cancer risk: Results from a prospective analysis (USA). Cancer Causes Control, 10, 1-11
63. Doss, M., Schermuly, E. & Koss, G (1976) Hexachlorobenzene porphyria in rats as a model for human chronic hepatic porphyrias. Ann. din. Res., 8, 171-181
64. Driscoll, M.S., Hassett, J.P., Fish, C.L. & Litten, S. (1991) Extraction efficiencies of organochlorine compounds from Niagara River water. Environ. Sci. Technol., 25, 1432-1439
65. Engst, R., Macholz, R.M. & Kujawa, M. (1976) The metabolism of hexachlorobenzene (HCB) in rats. Bull, environ. Contain. Toxicol., 16, 248-252
66. Environmental Protection Agency (1994a) Method 8121. Chlorinated hydrocarbons by gas chromatography: Capillary column technique. In: Test Methods for Evaluating Solid Waste - Physical/chemical Methods, Update II (US EPA No. SW-846), Washington DC, Office of Solid Waste.
67. Environmental Protection Agency (1994b) Method 8410. Gas chromatography/Fourier transform infrared (GC/FT-IR) spectrometry for semivolatile organics: capillary column. In: Test Methods for Evaluating Solid Waste -Physical/Chemical Methods, Update II (US EPA No. SW-846), Washington DC, Office of Solid Waste
68. Environmental Protection Agency (1995a) Method 505. Analysis of organohalide pesticides and commercial polychlorinated biphenyl (PCB) products in water by microextraction and gas chromatography [Rev. 2.1]. In: Methods for the Determination of Organic Compounds in Drinking Water, Supplement III (EPA Report No. EPA-600/R-95-131; US NTIS PB216616), Cincinnati, OH, Environmental Monitoring Systems Laboratory
69. Environmental Protection Agency (1995b) Method 508.1. Determination of chlorinated pesticides, herbicides, and organohalides by liquid-solid extraction and electron capture gas chromatography [Rev. 2.0]. In: Methods for the Determination of Organic Compounds in Drinking Water, Supplement III (EPA Report No. EPA-600/R-95-131; US NTIS PB216616), Cincinnati, OH, Environmental Monitoring Systems Laboratory
70. Environmental Protection Agency (1995c) Method 525.2. Determination of organic compounds in drinking water by liquid-solid extraction and capillary column gas chromatography/mass spectrometry [Rev. 2.0]. In: Methods for the Determination of Organic Compounds in Drinking Water, Supplement III (EPA Report No. EPA-600/R-95-131; US NTIS PB216616), Cincinnati, OH, Environmental Monitoring Systems Laboratory
71. Environmental Protection Agency (1995d) Method 551.1. Determination of chlorination byproducts, chlorinated solvents, and halogenated pesticides/herbicides in drinking water by liquid-liquid extraction and gas chromatography with electron-capture detection [Rev. 1.0]. In: Methods for the Determination of Organic Compounds in Drinking Water, Supplement III (EPA Report No. EPA-600/R-95-131; US NTIS PB-216616), Cincinnati, OH, Environmental Monitoring Systems Laboratory
72. Environmental Protection Agency (1996a) Method 8081A. Organochlorine pesticides by gas chromatography [Rev. 1]. In: Test Methods for Evaluating Solid Waste -Physical/ Chemical Methods, Update III (US EPA No. SW-846), Washington DC, Office of Solid Waste
73. Environmental Protection Agency (1996b) Method 8270C. Semivolatile organic compounds by gas chromatography/mass spectrometry (GC/MS) [Rev. 3]. In: Test Methods for Evaluating Solid Waste -Physical/Chemical Methods, Update III (US EPA No. SW-846), Washington, DC, Office of Solid Waste
74. Environmental Protection Agency (1996c) Method 8275A. Semivolatile organic compounds (PAHs and PCBs) in soil/sludges and solid wastes using thermal extraction/gas chromatography/mass spectrometry (TE/GS/MS) [Rev. 1]. In: Test Methods for Evaluating Solid Waste -Physical/Chemical Methods, Update III (US EPA No. SW-846), Washington, DC, Office of Solid Waste
75. Environmental Protection Agency (1999a) Method TO-04A. Determination of pesticides and polychlorinated biphenyls in ambient air using high volume polyurethane foam (PUF) sampling followed by gas chromatographic/multidetector detection (GC/MD). In: Compendium of Methods for the Determination of Toxic Compounds in Ambient Air, 2nd Ed. (EPA Report No. EPA-625/R-96-010b), Cincinnati, OH, Center for Environmental Research Information
76. Environmental Protection Agency (1999b) Method TO-10A. Determination of pesticides and polychlorinated biphenyls in ambient air using low volume polyurethane foam (PUF) sampling followed by gas chromatographic/multidetector detection (GC/MD). In: Compendium of Methods for the Determination of Toxic Compounds in Ambient Air, 2nd Ed. (EPA Report No. EPA-625/R-96-010b), Cincinnati, OH, Center for Environmental Research Information
77. Environmental Protection Agency (1999c) Methods for organic chemical analysis of municipal and industrial wastewater. Method 612 -Chlorinated hydrocarbons. US Code Fed. Regul, Title 40, Part 136, App. A, pp. 167-178
78. Environmental Protection Agency (1999d) Methods for organic chemical analysis of municipal and industrial wastewater. Method 625 -Base/neutrals and acids. US Code Fed. Regul., Title 40, Part 136, App. A, pp. 202-228
79. Environmental Protection Agency (1999e) Methods for organic chemical analysis of municipal and industrial wastewater. Method 1625, Revision B -Semivolatile organic compounds by isotope dilution GC/MS. US Code Fed. Regul., Title 40, Part 136, App. A, pp. 286-306
80. Environmental Protection Agency (2000) 1997 Toxics Release Inventory (EPA 745-F99-002), Washington DC, Office of Pollution Prevention and Toxics
81. Ertiirk, E., Lambrecht, R.W., Peters, H.A., Cripps, D.J., Gocmen, A., Morris, C.R. & Bryan, GT. (1986) Oncogenicity of hexachlorobenzene. In: Morris, C.R. & Cabrai, J.R.P., eds, Hexachlorobemene: Proceedings of an International Symposium (IARC Scientific Publications No. 77), Lyon, IARCPress, pp. 417-423
82. Falck, J., Jr, Ricci, A., Wolff, M.S., Godbold, J. & Deckers, P. (1992) Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch, environ. Health, 47, 143-146
83. FAO/UNEP (1997) Prior Informed Consent Decision Guidance Document: Hexachlorobenzene, Geneva, Rotterdam Convention on the Prior Informed Consent Procedure for Certain Hazardous Chemicals and Pesticides in International Trade
84. Feldman, E.S. & Bacon, B.R. (1989) Hepatic mitochondrial oxidative metabolism and lipid peroxidation in experimental hexachlorobenzene-induced porphyria with dietary carbonyl iron overload. Hepatology, 9, 686-692
85. Food and Drug Administration (1999) Methods 302, 303 and 304. In: Makovi, C.M. & McMahon, B.M., eds, Pesticide Analytical Manual, Vol. I: Mitltiresidue Methods, 3rd Rev. Ed., Management Methods Branch, Washington DC
86. Foster, W.G., Pentick, J.A., McMahon, A. & LeCavalier, P.R. (1992a) Ovarian toxicity of hexachlorobenzene (HCB) in the superovulated female rat. J. biochem. Toxicol., 7, 1-4
87. Foster, W.G., McMahon, A., Villeneuve, D.C. & Jarrell, J.F. (1992b) Hexachlorobenzene (HCB) suppresses circulating progesterone concentrations during the luteal phase in the cynomolgus monkey. J. appl. Toxicol., 12, 13-17
88. Foster, W.G., Pentick, J.A., McMahon, A. & Lecavalier, P.R. (1993) Body distribution and endocrine toxicity of hexachlorobenzene (HCB) in the female rat. J. appl. Toxicol., 13, 79-83
89. Foster, W.G., Mertineit, C., Yagminas, A., McMahon, A. & Lecavalier, P. (1995a) The effects of hexachlorobenzene on circulating levels of adrenal steroids in the ovariectomized rat. J. biochem. Toxicol., 10, 129-135
90. Foster, W.G., McMahon, A., Younglai, E.V., Jarrell, J.F. & Lecavalier, P. (1995b) Alterations in circulating ovarian steroids in hexachlorobenzene-exposed monkeys. Reprod. Toxicol., 9, 541-548
91. Foster, W.G., Jarrell, J.F., Younglai, E.V., Wade, M.G., Arnold, D.L. & Jordon, S. (1996) An overview of some reproductive toxicology studies conducted at Health Canada. Toxicol. ind. Health, 12, 447-459
92. Franklin, R.B., Breger, R.K. & Lech, J.J. (1983) Comparative effects of hexachloro- and hexabromobenzene on hepatic monooxygenase activity of male and female rats. J. Toxicol. environ. Health, 12, 223-234
93. Franklin, M.R., Phillips, J.D. & Kushner, J.P. (1997) Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of porphyria cutanea tarda. Toxicol. appl. Pharmacol, 147, 289-299
94. Fries, G.F. & Marrow, GS. (1976) Hexachlorobenzene retention and excretion by dairy cows. J. dairy Sci., 59, 475-480
95. Garrison, A.W. & Pellizzari, E.D. (1987) Application of the master analytical scheme to polar organic compounds in drinking water. In: Suffer, I.H. & Malaiyandi, M., eds, Organic Pollutants in Water: Sampling, Analysis, and Toxicity Testing (Advances in Chemistry Series No. 214), Washington DC, American Chemical Society, pp. 83-95
96. Gerhard, I., Daniel, V., Link, S., Monga, B. & Runnebaum, B. (1998) Chlorinated hydrocarbons in women with repeated miscarriages. Environ. Health Perspectives, 106, 675-681
97. Gocmen, A., Peters, H.A., Cripps, D.J., Bryan, GT. & Morris, C.R. (1989) Hexachlorobenzene episode in Turkey. Biomed. environ. Sci., 2, 36-43
98. Goerz, G., Vrzethum, W., Bolsen, K., Krieg, T. & Lissner, R. (1978) [Hexachlorobenzene (HCB)-induced porphyria in rats. Influence of HCB metabolites on the biosynthesis of haem.] Arch. dermatol. Res., 263, 189-196 (in German)
99. Goldey, E.S. & Taylor, D.H. (1992) Developmental neurotoxicity following premating maternal exposure to hexachlorobenzene in rats. Neurotoxicol. Teratol., 14, 15-21
100. Goldstein, J.A., Linko, P., Hahn, M.E., Gasiewicz, T.A. & Yeowell, H.N. (1986) Structure-activity relationships of chlorinated benzenes as inducers of hepatic cytochrome P-450 isoenzymes in the rat. In: Morris, C.R. & Cabrai, J.R.P., eds, Hexachlorobenzene: Proceedings of an International Symposium (I ARC Scientific Publications, No. 77), Lyon, IARCPress, pp. 519-526
101. Görski, T., Görska, E., Görecka, D. & Sikora, M. (1986) Hexachlorobenzene is non-genotoxic in short-term tests. In: Morris, C.R. & Cabrai, J.R.P., eds, Hexachlorobenzene: Proceedings of an International Symposium (IARC Scientific Publications No. 77), Lyon, IARCPress, pp. 399-401
102. Government of Canada (1993) Canadian Environmental Protection Act -Priority Substances List Assessment Report: Hexachlorobenzene, Ottawa, Canada Communication Group Publishing
103. Graef, V., Golf, S.W. & Tyrell, C. (1982) Further evidence for the participation of 5-steroids in the development of a porphyria induced by hexachlorobenzene. Arch. Toxicol., 50, 233-239
104. Grant, D.L., Iverson, F., Hatina, G.V. & Villeneuve, D.C. (1974) Effects of hexachlorobenzene on liver porphyrin levels and microsomal enzymes in the rat. Environ. Physiol. Biochem., 4, 159-165
105. Grimait, J.O., Sunyer, J., Moreno, V., Amaral, O.G., Sala, M., Resell, A., Anto, J.M. & Albaiges, J. (1994) Risk excess of soft-tissue sarcoma and thyroid cancer in a community exposed to airborne organochlorinated compound mixtures with high hexachlorobenzene content. Int. J. Cancer, 56, 200-203
106. Guerzoni, M.E., Del Cupolo, L. & Ponti, I. (1976) [Mutagenic activity of pesticides.] Riv. Sci. tecnol. aliment. Nutr. um., 6, 161-165 (in Italian)
107. Gustafson, D.L., Long, M.E., Thomas, R.S., Benjamin, S.A. & Yang, R.S.H. (2000) Comparative hepatocarcinogenicity of hexachlorobenzene, pentachlorobenzene, 1,2,4,5-tetrachlorobenzene, and 1,4-dichlorobenzene: Application of a medium-term liver focus bioassay and molecular and cellular indices. Toxicol. Sci., 53, 245-252
108. Gurtes, S., Failing, K., Neumann, K., Kleinstein, J., Georgii, S. & Brunn, H. (1998) Chloroorganic pesticides and polychlorinated biphenyls in breast tissue of women with benign and malignant breast disease. Arch, environ. Contain. Toxicol., 35, 140-147
109. Hahn, M.E., Gasiewicz, T.A., Linko, P. & Goldstein, J.A. (1988) The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice. Biochem. J., 254, 245-254
110. Hahn, M.E., Goldstein, J.A., Linko, P. & Gasiewicz, T.A. (1989) Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo. Evidence that hexachlorobenzene is a weak Ah receptor agonist. Arch. Biochem. Biophys., 270, 344-355
111. Haworth, S., Lawlor, T., Mortelmans, K., Speck, W. & Zeiger, E. (1983) Salmonella mutagenicity test results for 250 chemicals. Environ. Mutag., 5, 3-142
112. Hippelein, M., Kaupp, H., Dörr, G & McLachlan, M.S. (1993) Testing of a sampling system and analytical method for determination of semivolatile organic compounds in ambient air. Chemosphere, 26, 2255-2263
113. Hogue, C. (2000) Dioxins to be major issue at treaty negotiations. Chem. Eng. Neïvs, 20 March, 35
114. Hoppin, J.A., Tolbert, P.E., Holly, E.A., Brook, J.W., Korrick, S.A., Altshul, L.M., Zhang, R.H., Bracci, P.M., Burse, V.W. & Needham, L.L. (2000) Pancreatic cancer and serum organochlorine levels. Cancer Epidemiol. Biomarkers Prev., 9, 199-205
115. Hsu, J.P., Wheeler, H.G & Schattenberg, H.J. (1988) Analytical Sampling Methods of the Non-occupational Pesticide Exposure Study (NOPES) (EPA 600/9/88-0105), Washington DC, Environmental Protection Agency
116. IARC (1979) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 20, Some Halogenated Hydrocarbons, Lyon, IARCPress, pp. 155-178
117. IARC (1987) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Suppl. 7, Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, Lyon, IARCPress, pp. 219-220
118. Iatropoulos, M.J., Milling, A., Müller, W.F., Nohynek, G., Rozman, K., Coulston, F. & Korte, F. (1975) Absorption, transport and organotropism of dichlorobiphenyl (DCB), dieldrin, and hexachlorobenzene (HCB) in rats. Environ. Res., 10, 384-318
119. Ishidate, M., Jr (1988) Data Book of Chromosomal Aberration Test In Vitro, Amsterdam, Elsevier, p. 221
120. Jarrell, J.F., McMahon, A., Villeneuve, D., Franklin, C., Singh, A., Valli, V.E. & Bartlet, S. (1993) Hexachlorobenzene toxicity in the monkey primordial germ cell without induced porphyria. Reprod. Toxicol., 7, 41-47
121. Jarrell, J., Gocmen, A., Foster, W., Brant, R., Chan, S. & Sevcik, M. (1998) Evaluation of reproductive outcomes in women inadvertently exposed to hexachlorobenzene in southeastern Turkey in the 1950s. Reprod. Toxicol., 12, 469-476
122. Jones, R.E. & Chelsky, M. (1986) Further discussion concerning porphyria cutanea tarda and TCDD exposure. Arch, environ. Health, 41, 100-103
123. Khera, K.S. (1974) Teratogenicity and dominant lethal studies on hexachlorobenzene in rats. FoodCosmet. Toxicol, 12, 471-477
124. Kimbrough, R.D. & Linder, R.E. (1974) The toxicity of technical hexachlorobenzene in the Sherman strain rat. A preliminary study. Res. Commun, ehem. Pathol. Pharmacol., 8, 653-664
125. Kitchin, K.T., Linder, R.E., Scotti, T.M., Walsh, D., Curley, A.O. & Svendsgaard, D. (1982) Offspring mortality and maternal lung pathology in female rats fed hexachlorobenzene. Toxicology, 23, 33-39
126. Kleiman de Pisarev, D.L., Sancovich, H.A. & Ferramola de Sancovich, A.M. (1989) Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats. J. endocrinol. Invest., 12, 767-772
127. Kleiman de Pisarev, D.L., Rios de Molina, M.C. & San Martin de Viale, L.C. (1990) Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria. Biochem. Pharmacol., 39, 817-825
128. Kleiman de Pisarev, D.L., Ferramola de Sancovich, A.M. & Sancovich, H.A. (1995) Hepatic indices of thyroid status in rats treated with hexachlorobenzene. J. endocrinol. Invest., 18, 271-276
129. Knauf, V. & Hobson, W. (1979) Hexachlorobenzene ingestion by female rhesus monkeys: Tissue distribution and clinical symptomatology. Bull, environ. Contain. Toxicol., 21, 243-248
130. Koizumi, A. (1991) Experimental evidence for the possible exposure of workers to hexachlorobenzene by skin contamination. Br. J. ind. Med., 48, 622-628
131. Kondo, M. & Shimizu, Y. (1986) The effects of ethanol, estrogen and hexachlorobenzene on the activities of hepatic 5-aminolevulinate synthetase, 5-aminolevulinate dehydratase, and uroporphyrinogen decarboxylase in male rats. Arch. Toxicol., 59, 141-145
132. Koss, G., Koransky, W. & Steinbach, K. (1976) Studies on the toxicology of hexachlorobenzene. II. Identification and determination of metabolites. Arch. Toxicol., 35, 107-114
133. Koss, G., Seubert, S., Seubert, A., Koransky, W. & Ippen, H. (1978) Studies on the toxicology of hexachlorobenzene. III. Observations in a long-term experiment. Arch. Toxicol., 40, 285-294
134. Koss, G., Koransky, W. & Steinbach, K. (1979) Studies of the toxicology of hexachlorobenzene. IV. Sulphur-containing metabolites. Arch. Toxicol., 42, 19-31
135. Koss, G., Seubert, S., Seubert, A., Seidel, J., Koransky, W. & Ippen, H. (1983) Studies on the toxicology of hexachlorobenzene. V. Different phases of porphyria during and after treatment. Arch. Toxicol., 52, 13-22
136. Krishnan, K., Brodeur, J. & Charbonneau, M. (1991) Development of an experimental model for the study of hexachlorobenzene-induced hepatic porphyria in the rat. Fimdam. appl. Toxicol., 17, 433-41
137. Kuiper-Goodman, T., Grant, D.L., Moodie, C.A., Korsrud, GO. & Munro, I.C. (1977) Subacute toxicity of hexachlorobenzene in the rat. Toxicol. appl. Pharmacol., 40, 529-549
138. Lamparski, L.L., Langhorst, M.L., Nestrick, T.J. & Cutié, S. (1980) Gas-liquid Chromatographie determination of chlorinated benzenes and phenols in selected biological matrices. J. Assoc. off. anal. Cliem., 63, 27-32
139. Langhorst, ML. & Nestrick, T.J. (1979) Determination of chlorobenzenes in air and biological samples by gas chromatography with photoionization detection. Anal. Chem., 51, 2018-2025
140. Lewis, R.G & MacLeod, K.E. (1982) Portable sampler for pesticides and semivolatile industrial organic chemicals in air. Anal. Chem., 54, 310-315
141. Li, S.M.A., Dénomme, M.A., Leece, B., Safe, S., Dutton, D., Parkinson, A., Thomas, P.E., Ryan, D., Bandiera, S., Leik, L.M. & Levin, W. (1986) Hexachlorobenzene and substituted pentachlorobenzenes (X-C6C15) as inducers of hepatic cytochrome P-450-dependent mono-oxygenases. In: Morris, C.R. & Cabrai, J.R.P., eds, Hexachlorobenzene: Proceedings of an International Symposium (IARC Scientific Publications, No. 77), Lyon, IARCPress, pp. 527-534
142. Lide, D.R. & Milne, GW.A. (1996) Properties of Organic Compounds, Version 5.0, Boca Raton, FL, CRC Press [CD-ROM]
143. Lilienthal, H., Benthe, C., Heinzow, B. & Winneke, G (1996) Impairment of schedule-controlled behavior by pre- and postnatal exposure to hexachlorobenzene in rats. Arch. Toxicol., 70, 174-181
144. Liljegren, G., Hardell, L., Lindström, G., Dahl, P. & Magnuson, A. (1998) Case-control study on breast cancer and adipose tissue concentrations of congener specific polychlorinated biphenyls, DDE and hexachlorobenzene. Enr. J. Cancer Prev., 1, 135-140
145. Linko, P., Yeowell, H.N., Gasiewicz, T.A. & Goldstein, J.A. (1986) Induction of cytochrome P-450 isoenzymes by hexachlorobenzene in rats and aromatic hydrocarbon (Ah)responsive mice. J. biochem. Toxicol., 1, 95-107
146. Loaiza-Perez, A.I., Seisdedos, M.-T., Kleiman de Pisarev, D.L., Sancovich, H.A., Randi, A.S., Ferramola de Sancovich, A.M. & Santisteban, P. (1999) Hexachlorobenzene, a dioxin-type compound, increases malic enzyme gene transcription through a mechanism involving the thyroid hormone response element. Endocrinology, 140, 4142-4151
147. Loose, L.D., Pittman, K.A., Benitz, K.-F. & Silkworm, J.B. (1977)
148. Loose, L.D., Silkworm, J.B., Mudzinski, S.P., Pittman, K.A., Benitz, K.-F. & Mueller, W. (1979) Modification of the immune response by organochlorine xenobiotics. Drug chem. Toxicol., 21, 111-132
149. Lopez-Avila, V., Northcutt, R., Onstot, J., Wickham, M. & Billets, S. (1983) Determination of 51 priority organic compounds after extraction from standard reference materials. Anal. Chem., 55, 881-889
150. Lunde, G & Bjorseth, A. (1977) Human blood samples as indicators of occupational exposure to persistent chlorinated hydrocarbons. Sci. total Environ., 8, 241-246
151. Lunde, G & Ofstad, E.B. (1976) Determination of fat-soluble chlorinated compounds in fish. Fresenius'Z. anal. Chem., 282, 395-399
152. Manson, M.M. & Smith, A.G (1984) Effect of hexachlorobenzene on male and female rat hepatic gamma-glutamyl transpeptidase levels. Cancer Lett., 22, 227-234
153. Mazzei, E.S. & Mazzei, C.M. (1973) [Intoxication by a fungicide, hexachlorobenzene, contaminating wheat grains.] Sem. Hop. Paris, 49, 63-67 (in French)
154. Mehendale, H.M., Fields, M. & Matthews, H.B. (1975) Metabolism and effects of hexachloro-benzene on hepatic microsomal enzymes in the rat. J. agric. Food Chem., 23, 261-265
155. Melnikova, L.V., Belyakov, A.A., Smirnova, V.G & Kurenko, L.T. (1975) [Sanitary-chemical methods for determination of noxious substances encountered in the production of sodium pentachlorophenolate.] Gig. Tr. prof. Zabol., 7, 37-39 (in Russian)
156. Mendonça, GA.S., Eluf-Neto, J., Andrada-Serpa, M.J., Carmo, P.A.O., Barreto, H.H.C., Inomata, O.N.K. & Kussumi, T. A. (1999) Organochlorines and breast cancer: A case-control study in Brazil. Int. J. Cancer, 83, 596-600
157. Mendoza, C.E., Grant, D.L. & Shields, J.B. (1975) Body burden of hexachlorobenzene in suckling rats and its effects on various organs and on liver porphyrin accumulation. Environ, physiol. Biochem., 5, 460-464
158. Mes, J. (1992) Organochlorine residues in human blood and biopsy fat and their relationship. Bull, environ. Contain. Toxicol, 48, 815-820
159. Mes, J., Davies, D.J., Doucet, J., Weber, D. & McMullen, E. (1993) Levels of chlorinated hydrocarbon residues in Canadian human breast milk and their relationship to some characteristics of the donors. FoodAddit. Contain., 10, 429-441
160. Michielsen, C.P.P.C., Bloksma, N., Ultee, A., van Mil, F. & Vos, J.G (1997) Hexachlorobenzene-induced immunomodulation and skin and lung lesions: A comparison between brown Norway, Lewis, and Wistar rats. Toxicol. appl. Pharmacol., 144, 12-26
161. Michielsen, C.P.P.C., Bloksma, N., Klatter, F.A., Rozing, J., Vos, J.G & van Dijk, J.E. (1999) The role of thymus-dependent T cells in hexachlorobenzene-induced inflammatory skin and lung lesions. Toxicol. appl. Pharmacol., 161, 180-191
162. Miskiewicz, A.G & Gibbs, P.J. (1994) Organochlorine pesticides and hexachlorobenzene in tissues offish and invertebrates caught near a sewage outfall. Environ. Pollut., 84, 269-277
163. Moysich, K.B., Ambrosone, C.B., Vena, J.E., Shields, P.G., Mendola, P., Kostyniak, P., Greizerstein, H ., Graham, S., Marshall, J.R., Schisterman, E.F. & Freudenheim, J.L. (1998) Environmental organochlorine exposure and postmenopausal breast cancer risk. Cancer Epidemiol. Biomarkers Prev., 7, 181-188
164. Munch, D.J., Graves, R.L., Maxey, R.A. & Engel, T.M. (1990) Methods development and implementation for the National Pesticide Survey. Environ. Sci. Technol., 24, 1446-1451
165. Murray, H.E., Neff, G.S., Hrung, Y. & Giam, C.S. (1980) Determination of benzo(a)pyrene, hexachlorobenzene and pentachlorophenol in oysters from Galveston Bay, Texas. Bull, environ. Contain. Toxicol., 25, 663-667
166. Mussalo-Rauhamaa, H., Häsänen, E., Pyysalo, H., Antervo, K., Kauppila, R. & Pantzar, P. (1990) Occurrence of beta-hexachlorocyclohexane in breast cancer patients. Cancer, 66, 2124-2128
167. Nakashima, Y., Ohsawa, S., Umegaki, K. & Ikegami, S. (1997) Hexachlorobenzene accumulated by dams during pregnancy is transferred to suckling rats during early lactation. J. Nutr., 127, 648-654
168. Nam, K.-S. & King, J.W. (1994) Coupled SFE/SFC/GC for the trace analysis of pesticide residues in fatty food samples. J. high Resol. Chromatogr., 17, 577-582
169. National Institute for Occupational Safety and Health (2000) National Occupational Exposure Survey 1981-83, Cincinnati, OH, US Department of Health and Human Services, Public Health Service
170. Newsome, W.H. & Ryan, J.J. (1999) Toxaphene and other chlorinated compounds in human milk from northern and southern Canada: A comparison. Chemosphere, 39, 519-526
171. Newsome, W.H., Davies, D. & Doucet, J. (1995) PCB and organochlorine pesticides in Canadian human milk- 1992. Chemosphere, 30, 2143-2153
172. Nordström, M., Hardell, L., Lindstrom, G., Wingfors, H., Hardell, K. & Linde, A. (2000) Concentrations of organochlorines related to titers of Epstein-Barr virus early antigen IgG as risk factors for hairy cell leukemia. Environ. Health Perspectives, 108, 441-445
173. Oehme, M. & Stray, H. (1982) Quantitative determination of ultra-traces of chlorinated compounds in high-volume air samples from the Arctic using polyurethane foam as collection medium. Fresenhis'Z. anal. Chem., 311, 665-673
174. Oliver, B.G & Nicol, K.D. (1982) Chlorobenzenes in sediments, water, and selected fish from Lakes Superior, Huron, Erie, and Ontario. Environ. Sci. Technol., 16, 532-536
175. van Ommen, B., Adang, A.E., Brader, L., Posthumus, M.A., Muller, F. & van Bladeren, P.J. (1986) The microsomal metabolism of hexachlorobenzene. Origin of the covalent binding to protein. Biochem. Pharmacol., 35, 3233-3238
176. van Ommen, B., Hendriks, W., Bessems, J.GM., Geesink, G., Muller, F. & van Bladeren, P.J. (1989) The relation between the oxidative biotransformation of hexachlorobenzene and its porphyrinogenic activity. Toxicol. appl. Pharmacol., 100, 517-528
177. Onuska, F.I. & Terry, K.A. (1993) Extraction of pesticides from sediments using a microwave technique. Chromatographia, 36, 101-104
178. van Oostdam, J., Gilman, A., Dewailly, E., Usher, P., Wheatley, B., Kuhnlein, H., Neve, S., Walker, J., Tracy, B., Feely, M., Jerome, V. & Kwavnick, B. (1999) Human health implications of environmental contaminants in Arctic Canada: A review. Sci. total Environ., 230, 1-82
179. Pereira, M.A., Herren, S.L., Britt, A.L. & Khoury, M.M. (1982) Sex difference in enhancement of GGTase-positive foci by hexachlorobenzene and lindane in rat liver. Cancer Lett., 15, 95-101
180. Peters, H.A. (1976) Hexachlorobenzene poisoning in Turkey. Fed. Proc., 35, 2400-2403
181. Peters, H.A., Johnson, S.A.M., Cam, S., Oral, S., Müftü, Y. & Ergene, T. (1966) Hexachlorobenzene-induced porphyria: Effect of chelation on the disease, porphyrin and metal metabolism. Am. J. med. Sci., 251, 314-322
182. Peters, H.A., Cripps, D.J. & Gocmen, A. (1978) Porphyria 20 years after hexachlorobenzene exposure (Abstract No. PP 10). Neurology, 28, 333
183. Peters, H.A., Gocmen, A., Cripps, D.J., Bryan, GT. & Dogramaci, I. (1982) Epidemiology of hexachlorobenzene-induced porphyria in Turkey. Arch. Neurol., 39, 744-749
184. Peters, H.A., Gocmen, A., Cripps, D.J., Morris, C.R. & Bryan, GT. (1986) Porphyria turcica: Hexachlorobenzene-induced porphyria. Neurological manifestations and therapeutic trials of ethylenediaminetetraacetic acid in the acute syndrome. In: Morris, C.R. & Cabrai, J.R.P., eds, Hexachlorobenzene: Proceedings of an International Symposium, (I ARC Scientific Publications, No. 77), Lyon, IARCPress, pp. 575-579
185. Peters, H.A., Cripps, D.J., Gocmen, A., Bryan, G.T., Erturk, E. & Morris, CR. (1987) Turkish epidemic of hexachlorobenzene porphyria. A 30-year study. Ann. N.Y. Acad. Sci., 514, 183-190
186. Pylypiw, H.M., Jr (1993) Rapid gas Chromatographie method for the multiresidue screening of fruits and vegetables for organochlorine and organophosphate pesticides. J. AOACint., 76, 1369-1373
187. Queiroz, M.L.S., Bincoletto, C., Perlingeiro, R.C., Quadras, M.R. & Souza, C.A. (1998a) Immunoglobulin levels in workers exposed to hexachlorobenzene. Hum. exp. Toxicol., 17, 172-175
188. Queiroz, M.L.S., Quadros, M.R., Valadares, M.C. & Silveira, J.P. (1998b) Polymorphonuclear phagocytosis and killing in workers occupationally exposed to hexachlorobenzene. Immunopharm. Immunotoxicol., 20, 447-54
189. van Raaij, J.A., van den Berg, K.J., Engel, R., Bragt, P.C. & Notten, W.R. (1991a) Effects of hexachlorobenzene and its metabolites pentachlorophenol and tetrachlorohydroquinone on serum thyroid hormone levels in rats. Toxicology, 67, 107-116
190. van Raaij, J.A., van den Berg, K.J. & Notten, W.R. (1991b) Hexachlorobenzene and its metabolites pentachlorophenol and tetrachlorohydroquinone: Interaction with thyroxine binding sites of rat thyroid hormone carriers in vivo and in vitro. Toxicol. Lett., 59, 101-107
191. van Raaij, J.A., Frijters, C.M. & van den Berg, K.J. (1993a) Hexachlorobenzene-induced hypothyroidism. Involvement of different mechanisms by parent compound and metabolite. Biochem. Pharmacol., 46, 1385-1391
192. van Raaij, J.A., Kaptein, E., Visser, T.J. & van den Berg, K.J. (1993b) Increased glucuronidation of thyroid hormone in hexachlorobenzene-treated rats. Biochem. Pharmacol., 45, 627-631
193. Rahman, M.S., Bowadt, S. & Larsen, B. (1993) Dual-column GC analysis of Mediterranean fish for ten organochlorine pesticides and sixty two chlorobiphenyls. J. high Resol. Chromatogr., 16, 731-735
194. Randi, A.S., Sancovich, H.A., Feramola de Sancovich, A.M., Loaiza, A., Krawiec, L. & Kleiman de Pisarev, D.L. (1998) Hexachlorobenzene-induced alterations of rat hepatic microsomal membrane function. Toxicology, 125, 83-94
195. Ray, S., Bailey, M., Paterson, G., Metcalfe, T. & Metcalfe, C. (1998) Comparative levels of organochlorine compounds in flounders from the northeast coast of Newfoundland and an offshore site. Chemosphcre, 36, 2201-2210
196. Renner, G & Schuster, K.P. (1977) 2,4,5-TrichlorophenoI, a new urinary metabolite of hexachlorobenzene. Toxicol. appl. Pharmacol., 39, 355-356
197. Rietjens, I.M.C.M., Steensma, A., den Besten, C., van Tintelen, G., Haas, J., van Ommen, B. & van Bladeren, P.J. (1995) Comparative biotransformation of hexachlorobenzene and hexafluorobenzene in relation to the induction of porphyria. Eur. J. Pharmacol., 293, 293-299
198. Rios de Molina, M.C., Wainstok de Calmanovici, R. & San Martin de Viale, L.C. (1980) Investigations on the presence of porphyrinogen carboxylyase inhibitor in the liver of rats intoxicated with hexachlorobenzene. Int. J. Biochem., 12, 1027-1032
199. Rizzardini, M. & Smith, A.G (1982) Sex differences in the metabolism of hexachlorobenzene by rats and the development of porphyria in females. Biochem. Pharmacol., 31, 3543-3548
200. Rizzardini, M., Cantoni, L., Villa, P. & Ubezio, P. (1990) Biochemical, morphological and flow-cytometric evaluation of the effects of hexachlorobenzene on rat liver. Cell Biol. Toxicol., 6, 185-203
201. Rozman, K., Mueller, W., Coulston, F. & Körte, F. (1977) Long-term feeding study of hexachlorobenzene in rhesus monkeys. Chemosphere, 6, 81-84
202. Rozman, K., Gorski, J.R., Rozman, P. & Parkinson, A. (1986) Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria. Toxicol. Lett., 30, 71-78
203. Rumsby, P.C., Evans, J.G., Phillimore, H.E., Carthew, P. & Smith, A.G (1992) Search for Haras codon 61 mutations in liver tumours caused by hexachlorobenzene and Aroclor 1254 in C57BL/10ScSn mice with iron overload. Carcinogenesis, 13, 1917-1920
204. Sadtler Research Laboratories (1980) Sadtler Standard Spectra, 1980 Cumulative Molecular Formula Index, Philadelphia, PA, p. 82
205. Sala, M., Sunyer, J., Otero, R., Santiago-Suva, M., Camps, C. & Grimait, J. (1999a) Organochlorine in the serum of inhabitants living near an electrochemical factory. Occup. environ. Med., 56, 152-158
206. Sala, M., Sunyer, J., Otero, R., Santiago-Suva, M., Ozalla, D., Herrero, C., To-Figueras J., Kogevinas, M., Anto, J.M., Camps, C. & Grimait, J. (1999b) Health effects of chronic high exposure to hexachlorobenzene in a general population sample. Arch, environ. Health, 54, 102-109
207. Savela, A., Vuorela, R. & Kauppinen, T. (1999) ASA 1997 (Katsauksia 140), Helsinki, Finnish Institute of Occupational Health, p. 30 (in Finnish)
208. Schielen, P., Schoo, W., Tekstra, J., Oostermeijer, H.H.A., Seinen, W. & Bloksma, N. (1993) Autoimmune effects of hexachlorobenzene in the rat. Toxicol. appl. Pharmacol., 122, 233-243
209. Schielen, P., den Besten, C., Vos, J.G., van Bladeren, P.J., Seinen, W. & Bloksma, N. (1995) Immune effects of hexachlorobenzene in the rat: Role of metabolism in a 13-week feeding study. Toxicol. appl. Pharmacol., 131, 37-43
210. Seidel, V. & Linder, W. (1993) Universal sample enrichment technique for organochlorine pesticides in environmental and biological samples using a redesigned simultaneous steam distillation-solvent extraction apparatus. Anal. Chem., 65, 3677-3683
211. Seiden, A.I., Nygren, Y., Westberg, H.B. & Bodin, L.S. (1997) Hexachlorobenzene and octachlorostyrene in plasma of aluminium foundry workers using hexachloroethane for degassing. Occup. environ. Med., 54, 613-618
212. Seiden, A.I., Floderus, Y., Bodin, L.S., Westberg, H.B. & Thunell, S. (1999) Porphyrin status in aluminum foundry workers exposed to hexachlorobenzene and octachlorostyrene. Arch. environ. Health, 54, 248-253
213. Shan, T.H., Hopple, J.A. & Foster, GD. (1994) Alternative tissue analysis method developed for organochlorine contaminants in aquatic organisms. Bull, environ. Contain. Toxicol., 53, 382-389
214. Sherwood, R.L., Thomas, P.T., O'Shea, W.J., Bradof, J.N., Ratajczak, H.V., Graham, J.A. & Aranyi, C. (1989) Effects of inhaled hexachlorobenzene aerosols on rat pulmonary host defenses. Toxicol. ind. Health, 5, 451-461
215. Shirai, T., Miyata, Y., Nakanishi, K., Murasaki, G & Ito, N. (1978) Hepatocarcinogenicity of polychlorinated terphenyl (PCT) in ICR mice and its enhancement by hexachlorobenzene (HCB). Cancer Lett., 4, 271-275
216. Siekel, P., Chalupa, I., Beno, J., Blasko, M., Novotny, J. & Burian, J. (1991) A genotoxicological study of hexachlorobenzene and pentachloroanisole. Teratog. Carcinog. Mutag., 11, 55-60
217. da Suva Augusto, L.G., Lieber, S.R., Ruiz, M.A. & de Souza, C.A. (1997) Micronucleus monitoring to assess human occupational exposure to organochlorides. Environ. mol. Mutag., 29, 46-52
218. Simon, G.S., Tardiff, R.G. & Borzelleca, J.F. (1979) Failure of hexachlorobenzene to induce dominant lethal mutations in the rat. Toxicol. appl. Pharmacol., 47, 415-419
219. Sims, D.E., Singh, A., Donald, A., Jarrell, J. & Villeneuve, C. (1991) Alteration of primate ovary surface epithelium by exposure to hexachlorobenzene: A quantitative study. Histol. Histopathol., 6, 525-529
220. Sinclair, P.R., Gorman, N., Walton, H.S., Bernent, W.J., Dalton, T.P., Sinclair, J.F., Smith, A.G & Nebert, D.W. (2000) CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron. Toxicol. appl. Pharmacol., 162, 60-67
221. Smith, A.G & Cabrai, J.R. (1980) Liver-cell tumours in rats fed hexachlorobenzene. Cancer Lett., 11, 169-172
222. Smith, A.G & Francis, J.E. (1983) Synergism of iron and hexachlorobenzene inhibits hepatic uroporphyrinogen decarboxylase in inbred mice. Biochem. J., 214, 909-913
223. Smith, A.G., Francis, J.E., Dinsdale, D., Manson, MM. & Cabrai J.R.P. (1985) Hepatocarcinogenicity of hexachlorobenzene in rats and the sex difference in hepatic iron status and development of porphyria. Carcinogenesis, 6, 631-636
224. Smith, A.G., Wright, A.L. & Cabrai, J.R.P. (1986) Influence of hexachlorobenzene on thyroids of male hamsters. In: Morris, C.R. & Cabrai, J.R.P., eds, Hexachlorobenzene: Proceedings of an International Symposium (IARC Scientific Publications No. 77), Lyon, IAR.CPress, pp.357-359
225. Smith, A.G., Dinsdale, D., Cabrai, J.R.P. & Wright, A.L. (1987) Goitre and wasting induced in hamsters by hexachlorobenzene. Arch. Toxicol., 60, 343-349
226. Smith, A.G., Cabrai, J.R.P., Carthew, P., Francis, J.E. & Manson, M.M. (1989) Carcinogenicity of iron in conjunction with a chlorinated environmental chemical, hexachlorobenzene, in C57BL/10ScSn mice. Int. J. Cancer, 43, 92-96
227. Smith, A.G., Francis, J.E., Green, J.A., Greig, J.B., Wolf, C.R. & Manson, M.M. (1990) Sexlinked hepatic uroporphyria and the induction of cytochromes P450IA in rats caused by hexachlorobenzene and polyhalogenated biphenyls. Biochem. Pharmacol., 40, 2059-2068
228. Sopena de Kracoff, Y.E., Ferramola de Sancovich, A.M., Sancovich, H.A. & Kleiman de Pisarev, D.L. (1994) Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria. J. endocrinol. Invest., 17, 301-305
229. Stachel, B., Dougherty, R.C., Lahl, U., Schlosser, M. & Zeschmar, B. (1989) Toxic environmental chemicals in human semen: Analytical method and case studies. Andrologia, 21, 282-291
230. Stanley, J.S. (1986) Broad Scan Analysis of the FY82 National Human Adipose Tissue Survey Specimens -Volume I: Executive summary (EPA 560/5-86/035). Kansas City, MO, Midwest Research Institute (Prepared for the US Environmental Protection Agency, Office of Toxic Substances, Field Studies Branch)
231. Stewart, F.P. & Smith, A.G. (1987) Metabolism and covalent binding of hexachlorobenzene by isolated male and female rat hepatocytes. Biochem. Pharmacol., 36, 2232-2234
232. Stewart, F.P., Manson, M.M., Cabral, J.R.P. & Smith, A.G. (1989) Hexachlorobenzene as a promoter of diethylnitrosamine-initiated hepatocarcinogenesis in rats and comparison with induction of porphyria. Carcinogenesis, 10, 1225-1230
233. Stonard, M.D. (1975) Mixed type hepatic microsomal enzyme induction by hexachlorobenzene. Biochem. Pharmacol., 24, 1959-1963
234. Sundlof, S.F., Hansen, L.G., Koritz, G.D. & Sundlof, S.M. (1982) The pharmacokinetics of hexachlorobenzene in male beagles. Distribution, excretion, and pharmacokinetic model. Drug Metab. Disposition, 10, 371-381
235. Thomas, R.S., Gustafson, D.L., Ramsdell, H.S., el-Masri, H.A., Benjamin, S.A. & Yang, R.S. (1998) Enhanced regional expression of glutathione S-transferase Pl-1 with colocalized AP-1 and CYP 1A2 induction in chlorobenzene-induced porphyria. Toxicol. appl. Pharmacol., 150, 22-31
236. To-Figueras, J., Gómez-Catalán, J., Rodamilans, M. & Corbella, J. (1991) Studies on sex differences in excretion of sulphur derivatives of hexachlorobenzene and pentachloronitrobenzene by rats. Toxicol. Lett., 56, 87-94
237. To-Figueras, J., Gómez-Catalán, J., Rodamilans, M. & Corbella, J. (1992) Sulphur derivative of hexachlorobenzene in human urine. Hum. exp. Toxicol., 11, 271-273
238. To-Figueras, J., Barrot, C., Rodamilans, M., Gómez-Catalán, J., Torra, M., Brunei, M., Sabater, P. & Corbella, J. (1995) Accumulation of hexachlorobenzene in humans: A long standing risk. Hum. exp. Toxicol., 14, 20-23
239. To-Figueras, J., Sala, M., Otero, R., Barrot, C., Santiago-Suva, M., Rodamilans, M., Herrero, C., Grimait, J. & Sunyer, J. (1997) Metabolism of hexachlorobenzene in humans: Association between serum levels and urinary metabolites in a highly exposed population. Environ. Health Perspectives, 105, 78-83
240. den Tonkelaar, E.M., Verschuuren, H.G., Bankovska, J., de Vries, T., Kroes, R. & van Esch, GJ. (1978) Hexachlorobenzene toxicity in pigs. Toxicol. appl. Pharmacol., 43, 137-145
241. Trotter, W.J. & Dickerson, R. (1993) Pesticide residues in composited milk collected through the US Pasteurized Milk Network. J. Assoc. off. anal. Chem. int., 76, 1220-1225
242. Vandebriel, R.J., Meredith, C., Scott, M.P., Roholl, P.J.M. & van Loveren, H. (1998) Effects of in vivo exposure to bis(tri-n-butyltin)oxide, hexachlorobenzene, and benzo(o)pyrene on cytokine (receptor) mRNA levels in cultured rat splenocytes and on IL-2 receptor protein levels. Toxicol. appl. Pharmacol., 148, 126-136
243. Villeneuve, D.C., van Legten, M.J., den Tonkelaar, E.M., Grève, P.A., Vos, J.G., Speijers, GJ.A. & van Esch, GJ. (1977) Effect of food deprivation on low level hexachlorobenzene exposure in rats. Sci. total Environ., 8, 179-186
244. Vos, J.G., van Logten, M.J., Kreeftenberg, J.G & Kruizinga, W. (1979a) Hexachlorobenzeneinduced stimulation of the humoral immune response in rats. Ann. N.Y. Acad. Sci., 320, 535-550
245. Vos, J.G., van Logten, M.J., Kreeftenberg, J.G., Steerenberg, P.A. & Kruizinga, W. (1979b) Effect of hexachlorobenzene on the immune system of rats following combined pre- and post-natal exposure. Drug chem. Toxicol., 2, 61-76
246. Wainstok de Calmanovici, R., Billi de Catabbi, S., Aldonatti, C.A. & San Martin de Viale, L.C. (1986) Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyria. Biochem Pharmacol., 35, 2399-2405
247. Wainstok de Calmanovici, R., Billi de Catabbi, S., Aldonatti, C.A. & San Martin de Viale, L.C. (1989) Influence of the strain of rats on the induction of hexachlorobenzene induced porphyria. Int. J. Biochem., 21, 377-381
248. Wainstok de Calmanovici, R., Cochon, A.C., Zenklusen, J.C., Aldonatti, C., Cabrai, J.R.P. & San Martin de Viale, L.C. (1991) Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats. Cancer Lett., 58, 225-232
249. Waliszewski, S.M. & Szymczynski, GA. (1985) Inexpensive, precise method for the determination of chlorinated pesticide residues in soil. J. Chromatogr., 321, 480-483
250. Watts, R.R., Hodgson, D.W., Christ, H.L. & Moseman, R.F. (1980) Improved method for hexachlorobenzene and mirex determination with hexachlorobenzene confirmation in adipose tissue: Collaborative study. J. Assoc. off. anal. Chem., 63, 1128-1134
251. Weiderpass, E., Adami, H.-O., Baron, J.A., Wicklund-Glynn, A., Aune, M., Atuma, S. & Persson, I. (2000) Organochlorines and endometrial cancer risk. Cancer Epidemiol. Biomarkers Prev., 9, 487-493
252. WHO (1987) Pentachlorophenol (Environmental Health Criteria 71), Geneva, International Programme on Chemical Safety
253. WHO (1993) Guidelines for Drinking-water Quality, 2nd Ed., Vol. 1, Recommendations, Geneva, p. 84
254. WHO (1997) Hexachlorobenzene (Environmental Health Criteria 195), Geneva, International Programme on Chemical Safety
255. WHO (1999) Inventory of IPCS and Other WHO Pesticide Evaluations and Summary of Toxicological Evaluations Performed by the Joint Meeting on Pesticide Residues [JMPR} through 1999, 3rd Ed., Geneva, International Programme on Chemical Safety
256. Yess, N.J., Gundersson, E.L. & Roy, R.R. (1993) US Food and Drug Administration monitoring of pesticide residues in infant foods and adult foods eaten by infants/children. J. AOAC int., 76, 492-507
257. Zheng, T., Holford, T.R., Mayne, S.T., Tessari, J., Owens, P.H., Zham, S.H, Zhang, B., Dubrow, R., Ward, B., Carter, D. & Boyle, P. (1999) Environmental exposure to hexachlorobenzene (HCB) and risk of female breast cancer in Connecticut. Cancer Epidemiol. Biomarkers Prev., 8, 407-411