Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose

Drug Development and Industrial Pharmacy

Volumn 30, Issue 1, 2004, Pages 103-109

  Steele, D Fraser ^a   Tobyn, Michael ^a   Edge, Stephen ^a   Chen, Ansong ^a   Staniforth, John N ^a  

^a University of Bath   (United Kingdom)

Author keywords

High density MCC; MCC; Mechanical properties; Prosolv; Silicified MCC

Indexed keywords

MICROCRYSTALLINE CELLULOSE; PROSOLV; SILICIFIED MICROCRYSTALLINE CELLULOSE; UNCLASSIFIED DRUG;

ARTICLE; CAPSULE FILLING; DENSITY; FLOW; MECHANICS; PARTICLE SIZE; PHYSICAL CHEMISTRY; TABLET COMPRESSION;

CELLULOSE; CHEMISTRY, PHYSICAL; EXCIPIENTS; HARDNESS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POWDERS; SURFACE PROPERTIES; TENSILE STRENGTH;

EID: 1242343610     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120027517     Document Type: Article

References (15)

1. Bolhuis, G.K.; Chowhan, Z.K. Materials for direct compression. In Pharmaceutical Powder Compaction Technology; Alderborn, G., Nyström, C., Eds.; Marcel Dekker: New York, 1996; 419-500.
2. Nagamoto, S.; Hiroto, M.; Yoshihito, Y. Excipient Having High Compressibility and Process for Preparing the Same. European Patent 0609976, August 10, 1994.
3. Obae, K.; Iijima, H.; Imada, K. Morphological effect of microcrystalline cellulose particles on tablet tensile strength. Int. J. Pharm. 1999, 182, 155-164.
4. Cobb, J.; Zeleznik, J.; Montalto, T.; West, L.; Becker, J.; Sherwood, B.E. Compaction characterization of new high density PROSOLV HD. Proc 3rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Berlin, April 2000.
5. Cobb, J.; Becker, J.; Lynch, D.; Zeleznik, J. Flow characterisation of a new high density grade of silicified microcrystalline cellulose. Proc 3rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Berlin, April 2000.
6. Felton, L.A.; Garcia, D.I.; Farmer, R. Weight and weight uniformity of hard gelatin capsules filled with microcrystalline cellulose and silicified microcrystalline cellulose. Drug Dev. Ind. Pharm. 2002, 28, 467-472.
7. Guo, M.T.; Muller, F.X.; Augsburger, L.L. Evaluation of the plug formation process of silicified microcrystalline cellulose. Int. J. Pharm. 2002, 233, 99-109.
8. Tobyn, M.J.; McCarthy; Staniforth, J.N.; Edge, S. Physicochemical comparison between microcrystalline cellulose and silicified microcrystalline cellulose. Int. J. Pharm. 1998, 169, 183-194.
9. Edge, S.; Steele, D.F.; Chen, A.; Tobyn, M.J.; Staniforth, J.N. The mechanical properties of compacts of microcrystalline cellulose and silicified microcrystalline cellulose. Int. J. Pharm. 2000, 200, 67-72.
10. Sherwood, B.E.; Becker, J.W. A new class of high functionality excipients: silicified microcrystalline cellulose. Pharm. Technol. 1998, 22, 78-88.
11. Moreton, R.C. Cellulose, silicified microcrystal-line. In Handbook of Pharmaceutical Excipients, 3rd Ed.; Weller, P., Rowe, R.C., Eds.; Pharmaceutical Press, 2000; 110-111.
12. Carr, R.L., Jr. Evaluating the flow properties of solids. Chem. Eng. January, 1965, 72 (2), 163-168.
13. Fell, J.T.; Newton, J.M. Determination of tablet strength by diametrical compression test. J. Pharm. Sci. 1972, 59, 688-691.
14. Steele, D.F. Amine/microcrystalline cellulose interactions, PhD. thesis; University of Bath, 2002.
15. Edge, S.; Potter, U.J.; Steele, D.F.; Chen, A.; Tobyn, M.J.; Staniforth, J.N. The location of silicon dioxide in silicified microcrystalline cellulose. Pharm. Pharmacol. Commun. 1999, 5, 371-376.