Methyldibromoglutaronitrile in rinse-off products causes allergic contact dermatitis: An experimental study

British Journal of Dermatology

Volumn 150, Issue 1, 2004, Pages 90-95

  Jensen, C D ^a,b   Johansen, J D ^b   Menne T ^b,c   Andersen, K E ^a,b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b National Allergy Research Centre   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Allergic contact dermatitis; Methyldibromoglutaronitrile; Rinse off products; Use test

Indexed keywords

2 BROMO 2 BROMOMETHYLGLUTARONITRILE; NITRILE; PRESERVATIVE; SOAP; UNCLASSIFIED DRUG;

ADULT; AGED; ALLERGIC REACTION; ARM; ARTICLE; CLINICAL ARTICLE; CONTACT SENSITIZATION; CONTROLLED STUDY; EXPOSURE; FEMALE; FISHER EXACT TEST; HAND WASHING; HUMAN; MALE; PATCH TEST; PRIORITY JOURNAL; SKIN ALLERGY;

ADULT; AGED; ALLERGENS; COSMETICS; DERMATITIS, ALLERGIC CONTACT; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRILES; PATCH TESTS; PRESERVATIVES, PHARMACEUTICAL; SOAPS;

EID: 1242320227     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2004.05727.x     Document Type: Article

References (19)

1. Bruze M, Gruvberger B, Agrup G. Sensitization studies in the guinea pig with the active ingredients of Euxyl K 400. Contact Dermatitis 1988; 18: 37-9.
2. Hausen BM. The sensitizing potency of Euxyl K 400 and its components 1,2-dibromo-2,4-dicyanobutane and 2-phenoxyethanol. Contact Dermatitis 1993; 28: 149-53.
3. de Groot AC, de Cock PA, Coenraads PJ et al. Methyldibromoglutaronitrile is an important contact allergen in the Netherlands. Contact Dermatitis 1996; 34: 118-20.
4. van Ginkel CJ, Rundervoort GJ. Increasing incidence of contact allergy to the new preservative 1,2-dibromo-2,4-dicyanobutane (methyldibromoglutaronitrile). Br J Dermatol 1995; 132: 918-20.
5. Tosti A, Vincenzi C, Trevisi P et al. Euxyl K 400: incidence of sensitization, patch test concentration and vehicle. Contact Dermatitis 1995; 33: 193-5.
6. Vigan M, Brechat P. Sensitization to Euxyl K400: a prospective study in 1217 patients. Eur J Dermatol 1996; 6: 175-7.
7. Wilkinson JD, Shaw S, Andersen KE et al. Monitoring levels of preservative sensitivity In Europe. A 10-year overview (1991-2000). Contact Dermatitis 2002; 46: 207-10.
8. Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products intended for Consumers. Methyldibromo Glutaronitrile. Colipa no P77. Adopted by the SCCNFP during the 20th plenary meeting of 4 June 2002.
9. Wahlberg JE. Patch testing. In: Textbook of Contact Dermatitis (Rycroft RJG, Menné T, Frosch PJ, eds), 2nd edn. Berlin: Springer-Verlag, 1995; 438-68.
10. Andersen KE, Johansen JD, Bruze M et al. The time-dose response relationship for elicitation of contact dermatitis in isoeugenol allergic individuals. Toxicol Appl Pharmacol 2001; 170: 166-71.
11. Agner T, Johansen JD, Overgaard L et al. Combined effects of irritants and allergens. Contact Dermatitis 2002; 47: 21-6.
12. McLelland J, Shuster S, Matthews JNS. Irritants increase the response to an allergen in allergic contact-dermatitis. Arch Dermatol 1991; 127: 1016-9.
13. Zachariae C, Rastogi SC, Devantier C et al. Methyldibromo glutaronitrile: clinical experience and exposure-based risk assessment. Contact Dermatitis 2003; 48: 150-4.
14. Diba VC, Chowdhury MMU, Adisesh A et al. Occupational allergic contact dermatitis in hospital workers caused by methyldibromo glutaronitrile in a work soap. Contact Dermatitis 2003; 48: 118-9.
15. Tosti A, Guerra L, Bardazzi F et al. Euxyl K 400: a new sensitizer in cosmetics. Contact Dermatitis 1991; 25: 89-93.
16. Cosmetic Ingredient Review Expert Panel of the Cosmetic Toiletry Fragrance Association. Final report on the safety assessment of methylisothiazolinone and methylisochloroisothiazolinone. J Am Coll Toxicol 1992; 11: 75-128.
17. Frosch PJ, Lahti A, Hannuksela M et al. Chloromethylisothiazolone methylisothiazolone (CMI/MI) use test with a shampoo on patch-test-positive subjects - results of a multicenter double-blind crossover trial. Contact Dermatitis 1995; 32: 210-7.
18. Weaver JE, Cardin CW, Maibach HI. Dose-response assessments of Kathon biocide. 1. Diagnostic use and diagnostic threshold patch testing with sensitized humans. Contact Dermatitis 1985; 12: 141-5.
19. Tosti A, Vincenzi C, Smith KA. Provocative use testing of methyldibromo glutaronitrile in a cosmetic shampoo. Contact Dermatitis 2000; 42: 64-7.