Comparative immune responses to candidate arthritogenic bacteria do not confirm a dominant role for Klebsiella pneumonia in the pathogenesis of familial ankylosing spondylitis

Rheumatology

Volumn 43, Issue 2, 2004, Pages 148-155

  Stone, M A ^a,b   Payne, U ^a   Schentag, C ^a   Rahman, P ^c   Pacheco Tena, C ^a   Inman, Robert D ^a,b,d  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^d TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Ankylosing spondylitis; HLA B27; Immune responses; Klebsiella pneumoniae

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G;

ADULT; ANKYLOSING SPONDYLITIS; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGENICITY; ARTICLE; CASE CONTROL STUDY; CELLULAR IMMUNITY; CHLAMYDIA TRACHOMATIS; CLINICAL FEATURE; CONTROLLED STUDY; DEMOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; ETHNOLOGY; FAMILIAL DISEASE; FAMILY; FEMALE; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE ACTIVATION; YERSINIA ENTEROCOLITICA;

ADULT; AGED; ANTIBODIES, BACTERIAL; CASE-CONTROL STUDIES; FEMALE; HUMANS; IMMUNITY, CELLULAR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; SPONDYLITIS, ANKYLOSING; STATISTICS; T-LYMPHOCYTES;

EID: 1242319535     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/keg482     Document Type: Article

References (32)

1. Ebringer RW, Cawdell DR, Cowling P, Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis 1978;37:146-51.
2. Ebringer A. The relationship between Klebsiella infection and ankylosing spondylitis. Baillière's Clin Rheumatol 1989;3:321-38.
3. Stebbings S, Munro K, Simon MA et al. Comparison of the faecal microflora of patients with ankylosing spondylitis and controls using molecular methods of analysis. Rheumatology 2002;41:1395-401.
4. van Kregten E, Huber-Bruning O, Vandenbroucke JP, Willers JM. No conclusive evidence of an epidemiological relation between Klebsiella and ankylosing spondylitis. J Rheumatol 1991; 18:384-8.
5. Schwimmbeck PL, Yu DT, Oldstone MB. Autoantibodies to HLA B27 in the sera of HLA B27 patients with ankylosing spondylitis and Reiter's syndrome. Molecular mimicry with Klebsiella pneumoniae as potential mechanism of autoimmune disease. J Exp Med 1987;166:173-81.
6. Inman RD, Chiu B, Johnston ME, Falk J. Molecular mimicry in Reiter's syndrome: cytotoxicity and ELISA studies of HLA-microbial relationships. Immunology 1986;58:501-6.
7. Albert LJ, Inman RD. Molecular mimicry and autoimmunity. N Engl J Med 1999;341:2068-74.
8. Seager K, Bashir HV, Geczy AF, Edmonds J, Vere-Tyndall A. Evidence for a specific B27-associated cell surface marker on lymphocytes of patients with ankylosing spondylitis. Nature 1979;277:68-70.
9. Edmonds J, Macauley D, Tyndall A et al. Lymphocytotoxicity of anti-Klebsiella antisera in ankylosing spondylitis and related arthropathies: patient and family studies. Arthritis Rheum 1981;24:1-7.
10. Geczy AF, Yap J. A survey of isolates of Klebsiella pneumoniae which cross-react with HLA-B27-associated cell-surface structure on the lymphocytes of patients with ankylosing spondylitis. J Rheumatol 1982;9:97-100.
11. Ahmadi K, Wilson C, Tiwana H, Binder A, Ebringer A. Antibodies to Klebsiella pneumoniae lipopolysaccharide in patients with ankylosing spondylitis. Br J Rheumatol 1998;37:1330-3.
12. Cancino-Diaz ME, Perez-Salazar JE, Dominguez-Lopez L et al. Antibody response to Klebsiella pneumoniae 60 kDa protein in familial and sporadic ankylosing spondylitis: role of HLA-B27 and characterization as a GroEL-like protein. J Rheumatol 1998;25: 1756-64.
13. Cooper R, Fraser SM, Sturrock RD, Gemmell CG. Raised titres of anti-klebsiella IgA in ankylosing spondylitis, rheumatoid arthritis, and inflammatory bowel disease. Br Med J Clin Res Ed 1988;296:1432-4.
14. Khalafpour S, Ebringer A, Abuljadayel I, Corbett M. Antibodies to Klebsiella and Proteus microorganisms in ankylosing spondylitis and rheumatoid arthritis patients measured by ELISA. Br J Rheumatol 1988;27(Suppl. 2):86-9.
15. Maki-Ikola O, Penttinen M, Von Essen R, Gripenberg-Lerche C, Isomaki H, Granfors K. IgM, IgG and IgA class enterobacterial antibodies in serum and synovial fluid in patients with ankylosing spondylitis and rheumatoid arthritis. Br J Rheumatol 1997;36: 1051-3.
16. Sahly H, Podschun R, Ullmann U. Increased antibody responses to Klebsiella serotypes K26, K36, and K50 in patients with ankylosing spondylitis. Rheumatology 1999;38:481-2.
17. Sahly H, Podschun R, Kekow J, Nolle B, Gross WL, Ullmann U. Humoral immune response to Klebsiella capsular polysaccharides in HLA-B27-positive patients with acute anterior uveitis and ankylosing spondylitis. Autoimmunity 1998;28:209-15.
18. Maki-Ikola O, Nissila M, Lehtinen K, Leirisalo-Repo M, Granfors K. IgA1 and IgA2 subclass antibodies against Klebsiella pneumoniae in the sera of patients with peripheral and axial types of ankylosing spondylitis. Ann Rheum Dis 1995;54:631-5.
19. Tiwana H, Walmsley RS, Wilson C el al. Characterization of the humoral immune response to Klebsiella species in inflammatory bowel disease and ankylosing spondylitis. Br J Rheumatol 1998;37:525-31.
20. Braun J, Tuszewski M, Ehlers S et al. Nested polymerase chain reaction strategy simultaneously targeting DNA sequences of multiple bacterial species in inflammatory joint diseases. II. Examination of sacroiliac and knee joint biopsies of patients with spondyloarthropathies and other arthritides. J Rheumatol 1997;24:1101-5.
21. Smieja M, MacPherson DW, Kean W et al. Randomised, blinded, placebo controlled trial of doxycycline for chronic seronegative arthritis. Ann Rheum Dis 2001;60:1088-94.
22. van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum 1984;27:361-8.
23. Garrett S, Jenkinson T, Kennedy G, Whitelock H, Gaisfor P, Calin A. A new approach to defining disease status in ankylosing spondylitis: The Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 1994;21:2286-91.
24. Calin A, Garrett S, Whitelock H et al. A new approach to defining functional ability in ankylosing spondylitis: The development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol 1994;21:2281-5.
25. Ward MM. Health related quality of life in ankylosing spondylitis: A survey of 175 patients. Arthritis Care Res 1999;12: 247-55.
26. Inman RD, Johnston ME, Chiu B, Falk J, Petric M. Immunochemical analysis of immune response to Chlamydia trachomatis in Reiter's syndrome and nonspecific urethritis. Clin Exp Immunol 1987;69:246-54.
27. Dominguez-Lopez ML, Cancino-Diaz ME, Jimenez-Zamudio L, Granados-Arreola J, Burgos-Vargas R, Garcia-Latorre E. Cellular immune response to Klebsiella pneumoniae antigens in patients with HLA-B27+ ankylosing spondylitis. J Rheumatol 2000;27:1453-60.
28. Geczy AF, Seager K, Bashir HV, Vere-Tyndall A, Edmonds J. The role of Klebsiella in the pathogenesis of ankylosing spondylitis. II. Evidence for a specific B27-associated marker on the lymphocytes of patients with ankylosing spondylitis. J Clin Lab Immunol 1980;3:23-8.
29. Ebringer R. Acute anterior uveitis and faecal carriage of Gram-negative bacteria. Br J Rheumatol 1988;27(Suppl. 2):42-5.
30. Tani Y, Sato H, Tanaka N, Hukuda S. Antibodies against bacterial lipopolysaccharides in Japanese patients with ankylosing spondylitis. Br J Rheumatol 1997;36:491-3.
31. Hohler T, Hug R, Schneider PM et al. Ankylosing spondylitis in monozygotic twins: studies on immunological parameters. Ann Rheum Dis 1999;58:435-40.
32. Hermann E, Sucke B, Droste U, Meyer zum Buschenfelde KH. Klebsiella pneumoniae-reactive T cells in blood and synovial fluid of patients with ankylosing spondylitis. Comparison with HLA-B27+ healthy control subjects in a limiting dilution study and determination of the specificity of synovial fluid T cell clones. Arthritis Rheum 1995;38:1277-82.