Simple spike and complex spike activity of floccular Purkinje cells during the optokinetic reflex in mice lacking cerebellar long-term depression

European Journal of Neuroscience

Volumn 19, Issue 3, 2004, Pages 687-697

  Goossens, H H L M ^a,b   Hoebeek, F E ^a   Van Alphen, A M ^a   Van Der Steen, J ^a   Stahl, J S ^c   De Zeeuw, C I ^a   Frens, M A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebellar and vestibular nuclei; Genetic manipulation; Heterosynaptic plasticity; Motor learning; Vestibulo ocular reflex

Indexed keywords

PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBELLUM FLOCCULUS; LONG TERM DEPRESSION; MOUSE; NONHUMAN; OPTOKINETIC STIMULATION; PRIORITY JOURNAL; PURKINJE CELL; SPIKE WAVE; STIMULUS RESPONSE; SYNAPSE; WILD TYPE;

ACTION POTENTIALS; ANIMALS; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, RADIATION; EYE MOVEMENTS; KINETICS; LONG-TERM DEPRESSION (PHYSIOLOGY); MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; PHOTIC STIMULATION; PURKINJE CELLS; REGRESSION ANALYSIS; VISUAL PERCEPTION;

EID: 1242317831     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0953-816X.2003.03173.x     Document Type: Article

References (26)

1. Aiba, A., Kano, M., Chen, C., Stanton, M.E., Fox, G.D., Herrup, K., Zwingman, T.A. & Tonegawa, S. (1994) Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell, 79, 377-388.
2. Conquet, F., Bashir, Z.I., Davies, C.H., Daniel, H., Ferraguti, F., Bordi, F., Franz-Bacon, K., Reggian, A., Matarerse, V., Conde, F. et al. (1994) Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature, 372, 237-242.
3. De Zeeuw, C.I., Wylie, D.R., DiGiorgi, P.L. & Simpson, J.I. (1994) Projections of individual Purkinje cells of identified zones in the flocculus to the vestibular and cerebellar nuclei in the rabbit. J. Comp. Neurol., 349, 428-447.
4. De Zeeuw, C.I., Wylie, D.R., Stahl, J.S. & Simpson, J.I. (1995) Phase relations of Purkinje cells in the rabbit flocculus during compensatory eye movements. J. Neurophys., 75, 2051-2064.
5. De Zeeuw, C.I., Hansel, C., Bian, F., Koekkoek, S.K.E., van Alphen, A.M., Linden, D.J. & Oberdick, J. (1998) Expression of a protein kinase C inhibitor in Purkinje cells blocks cerebellar LTD and adaptation of the vestibulo-ocular reflex. Neuron, 20, 495-508.
6. Eggermont, J.J. (1990) The Correlative Brain. Braitenberg, V. (ed.). Springer Verlag, New York.
7. Frens, M.A., Mathoera, A.L. & van der Steen, J. (2001) Floccular complex spike response to transparent retinal slip. Neuron, 30, 795-801.
8. Funabiki, K., Mishina, M. & Hirano, T. (1995) Retarded vestibular compensation in mutant mice deficient in δ2 glutamate receptor subunit. Neuroreport, 7, 189-192.
9. Gao, W., Dunbar, R.L., Chen, G., Reinert, K.C., Oberdick, J. & Ebner, T.J. (2003) Optical imaging of long-term depression in the mouse cerebellar cortex in vivo. J. Neurosci., 23, 1859-1866.
10. Goossens, J., Daniel, H., Rancillac, A., van der Steen, J., Oberdick, J., Crépel, F., De Zeeuw, C.I. & Frens, M.A. (2001) Expression of protein kinase C inhibitor blocks cerebellar long-term depression without affection Purkinje cell excitability in alert mice. J. Neurosci., 21, 5813-5823.
11. Graf, W., Simpson, J.I. & Leonard, C.S. (1988) Spatial organization of visual messages of the rabbit's cerebellar flocculus. II. Complex and simple spike responses of Purkinje cells. J. Neurophysiol., 60, 2091-2121.
12. Ito, M. (1982) Cerebellar control of the vestibulo-ocular reflex. Around the flocculus hypothesis. Annu. Rev. Neurosci., 5, 275-296.
13. Ito, M. (1998) Cerebellar learning in the vestibulo-ocular reflex. TINS, 2, 313-321.
14. Kashiwabuchi, N., Ikeda, K., Araki, K., Hirano, T., Shibuki, K., Tkayama, C., Inoue, Y.L., Kutsuwada, T., Yagi, T. & Kang, Y. (1995) Impairment of motor coordination, Purkinje cells synapse formation, and cerebellar long-term depression in GluRδ2 mutant mice. Cell, 81, 245-252.
15. Lev-Ram, V., Wong, S.T., Storm, D.R. & Tsien, R.Y. (2002) A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP. Proc. Natl Acad. Sci. U.S.A., 99, 8389-8393.
16. Linden, D.J. & Connor, J.A. (1995) Long-term synaptic depression. Annu. Rev. Neurosci., 18, 319-357.
17. Lisberger, S.G. (1998) Cerebellar LTD: a molecular mechanism of behavioural learning? Cell, 92, 701-704.
18. Miles, F.A. & Lisberger, S.G. (1981) Plasticity in the vestibulo-ocular reflex. A new hypothesis. Annu. Rev. Neurosci., 4, 273-299.
19. Press, W.H., Flannery, B.P., Teukolsky, S.A. & Vettering, W.T. (1992) Numerical Recipes in C, 2nd Edn. Cambridge University Press, Cambridge, MA.
20. Scheirer, C.J., Ray, W.S. & Hare, N. (1976) The analysis of ranked data derived from completely randomised factorial designs. Biometrics, 32, 429-434.
21. Shibuki, K., Gomi, H., Chen, L., Bao, S., Kim, J.J., Wakatsuki, H., Fujisaki, T., Fujimoto, K., Katoh, A., Ikeda, T. et al. (1996) Deficient cerebellar long-term depression, impaired eyeblink conditioning, and normal motor coordination in GFAP mutant mice. Neuron, 16, 586-599.
22. Simpson, J.I., Leonard, C.S. & Soodak, R.E. (1988) The accessory optic system of rabbit. II. Spatial organization of direction selectivity. J. Neurophysiol., 60, 2055-2072.
23. Simpson, J.I., Wylie, D.R. & De Zeeuw, C.I. (1996) On climbing fiber signals and their consequences. Beh. Brain Sci., 19, 380-394.
24. Stahl, J.S. & Simpson, J.I. (1995) Dynamics of abducens nucleus neurons in the awake rabbit. J. Neurophysiol., 73, 1383-1395.
25. Van Alphen, A.M., Stahl, J.S. & De Zeeuw, C.I. (2001) The dynamic characteristics of the mouse horizontal vestibulo-ocular and optokinetic response. Brain Res., 890, 296-305.
26. Van Alphen, A.M. & De Zeeuw, C.I. (2002) Cerebellar LTD facilitates but is not essential for long-term adaptation of the vestibulo-ocular reflex. Eur. J. Neurosci., 16, 486-490.