Effects of Neopterin on the Proliferation and Differentiation of Hematopoietic Progenitors Derived from Human Umbilical Cord Blood

Pteridines

Volumn 14, Issue 4, 2003, Pages 129-132

  Kawakami, Yutaka ^a   Aizawa, Shin ^a   Hiramoto, Masaki ^a   Tsuboi, Isao ^a   Wakasugi, Kazunori ^b  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL UNIVERSITY HACHIOJI MEDICAL CENTER   (Japan)

Author keywords

CD34; Cord blood; Hematopoiesis; Neopterin; Stromal cell

Indexed keywords

BIOCHEMICAL MARKER; CD34 ANTIGEN; HEMOPOIETIC GROWTH FACTOR; NEOPTERIN; PTERIDINE;

ARTICLE; BONE MARROW; BONE MARROW CULTURE; BURST FORMING UNIT E; CELL ACTIVATION; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; COLONY FORMING UNIT GM; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LEUKOCYTE COUNT; PRIORITY JOURNAL; SPLEEN; STROMA CELL; UMBILICAL CORD BLOOD;

MURINAE;

EID: 1242317655     PISSN: 09334807     EISSN: 21954720     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Rembold H, Gyure WL. Biochemistry of pteridines. Angew Chem 1972; 84: 1088-1092
2. Huber C, Batchelor JR, Fuchs D, Hausen A, Lang A, Niederwieser A, Reibnegger G, Swetly P, Troppmair J, Wachter H. Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma. J Exp Med 1984; 160: 310-316
3. Niederweiser D, Huber C, Gratwohl A, Bannert P, Fuchs D, Hausen A, Reibnegger G, Speck B, Wachter H. Neopterin as a new biochemical marker in the clinical monitoring of bone marrow transplant recipients. Transplantation 1984; 38: 497-500
4. Reibnegger G, Aulitzky W, Huber C, Margreiter R, Riccabona G, Wachter H. Neopterin in urine and serum of renal allograft recipients. J Clin Chem Biochem 1986; 24: 770-775
5. Schobersberger W, Hoffmann G, Hobisch-Hagen P, Hobisch-Hagen P, Bock G, Volkl H, Baier-Bitterlich G, Wirleitner B, Wachter H, Fuchs D. Neopterin and 7,8-dihydroneopterin induce apoptosis in the rat alveolar epithelial cell line L2. FEBS Lett 1996; 397: 263-268
6. Schobersberger W, Jelkmann W, Fandrey J, Frede S, Wachter H, Fuchs D. Neopterin-induced suppression of erythropoietin production in vitro. Pteridines 1995; 6: 12-16
7. Uberall F, Werner-Felmayer G, Schubert C, Grunicke H, Wachter H, Fuchs D. Neopterin derivatives together with cyclic guanosine monophosphate induce c-fos gene expression. FEBS Lett 1994; 352: 11-14
8. Aizawa S, Hiramoto M, Araki S, Hoshi H, Kojima S, Wakasugi K. In vivo stimulatory effects of neopterin on hematopoiesis. Pteridines 1998; 9: 13-17
9. Aizawa S, Hiramoto M, Araki S, Negishi S, Kimura Y, Hoshi H, Kojima S, Wakasugi K. Stimulatoly effects of neopterin on hematopoiesis in vitro are mediated by activation of stromal cell function. Hematol Oncol 1998; 16: 57-67
10. Dexter TM, Allen TD, Laitha LG. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 1977, 91, 335-344
11. Mori KJ, Fujitake H, Okubo H, Dexter TM, Ito Y. Quantitative development of adherent cell colonies in bone marrow cell culture in vitro. Exp Hematol 1979, 7, 171-176
12. Hiramoto M, Aizawa S, Iwase O, Nakano M, Toyama K, Hoque M, Nabeshima R, Kaidow A, Imai T, Hoshi H, Handa H. Stimulatory effects of substance P on CD34 positive cell proliferation and differentiation in vitro are mediated by the modulation of stromal cell function. Int J Mol Med 1998, 1, 347-354
13. Heard J, Fishekson S, Varet B. Role of colony-stimulating activity in murine long-term bone marrow cultures: evidence for its production and consumption by the adherent cells. Blood 1982, 59, 761-767
14. Schofield R. The relationship between the spleen colony forming cell and hemopoietic stem cell. A hypothesis. Blood Cell 1978, 4, 7-25
15. Aizawa S, Tavassoli M. In vitro homing of hematopoietic stem cells is mediated by recognition system with galactosyl and mannosyl specificities. Pro Natl Acad Sci USA 1987, 84, 4485-4489
16. Wachter H, Fuchs D, Hausen A, Reibnegger G, Weiss G, Werner ER, Werner-Felmayer G. Neopterin: Biochemistry-Methods-Clinical Application. De Gruyter, Berlin-New York, 1992.
17. Hamerlinck FFV. Neopterin: a review. Exp Dermatol 1999, 8, 167-176