The SLC31 (Ctr) copper transporter family

Pflugers Archiv European Journal of Physiology

Volumn 447, Issue 5, 2004, Pages 752-755

  Petris, Michael J ^a  

^a University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CARRIER PROTEIN; COPPER TRANSPORTER; COPPER TRANSPORTER 1; COPPER TRANSPORTER 2; NEUROTRANSMITTER; PROTEIN SLC31A1; PROTEIN SLC31A2; UNCLASSIFIED DRUG;

COPPER TRANSPORT; GENETIC DISORDER; HOMEOSTASIS; HUMAN; IMMUNOCYTOCHEMISTRY; IRON METABOLISM; MENKES SYNDROME; METABOLIC DISORDER; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; TRANSLATION REGULATION; TRANSPORT KINETICS; WILSON DISEASE;

ANIMALS; BIOLOGICAL TRANSPORT; CATION TRANSPORT PROTEINS; COPPER; HUMANS; MULTIGENE FAMILY;

EID: 1242317649     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-003-1092-1     Document Type: Review

References (27)

1. Harris ED (2000) Cellular copper transport and metabolism. Annu Rev Nutr 20:291-310
2. Dancis A, Haile D, Yuan DS, Klausner RD (1994) The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake. J Biol Chem 269:25660-25667
3. Knight SA, Labbe S, Kwon LF, Kosman DJ, Thiele DJ (1996) A widespread transposable element masks expression of a yeast copper transport gene. Genes Dev 10:1917-1929
4. Klomp AE, Juijn JA, Van Der Gun LT, Van Den Berg IE, Berger R, Klomp LW (2003) The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself. Biochem J 370:881-889
5. Zhou B, Gitschier J (1997) hCTR1: a human gene for copper uptake identified by complementation in yeast. Proc Natl Acad Sci USA 94:7481-7486
6. Kampfenkel K, Kushnir S, Babiychuk E, Inze D, Van Montagu M (1995) Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue. J Biol Chem 270:28479-28486
7. Lee J, Prohaska JR, Dagenais SL, Glover TW, Thiele DJ (2000) Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant. Gene 254:87-96
8. Riggio M, Lee J, Scudiero R, Parisi E, Thiele DJ, Filosa S (2002) High affinity copper transport protein in the lizard Podarcis sicula: molecular cloning, functional characterization and expression in somatic tissues, follicular oocytes and eggs. Biochim Biophys Acta 1576:127-135
9. Eisses JF, Kaplan JH (2002) Molecular characterization of hCTR1, the human copper uptake protein. J Biol Chem 277:29162-29171
10. Puig S, Lee J, Lau M, Thiele DJ (2002) Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake. J Biol Chem 277:26021-26030
11. Pena MMO, Lee J, Thiele DJ (1999) A delicate balance: homeostatic control of copper uptake and distribution. J Nutr 129:1251-1260
12. Puig S, Thiele DJ (2002) Molecular mechanisms of copper uptake and distribution. Curr Opin Chem Biol 6:171-180
13. Lee J, Pena MM, Nose Y, Thiele DJ (2002) Biochemical characterization of the human copper transporter Ctrl. J Biol Chem 277:4380-4387
14. Klomp AE, Tops BB, Van Denberg IE, Berger R, Klomp LW (2002) Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1). Biochem J 364:497-505
15. Pena MM, Puig S, Thiele DJ (2000) Characterization of the Saccharomyces cerevisiae high-affinity copper transporter Ctr3. J Biol Chem 275:33244-33251
16. Portnoy ME, Schmidt PJ, Rogers RS, Culotta VC (2001) Metal transporters that contribute copper to metallochaperones in Saccharomyces cerevisiae. Mol Genet Genome 265:873-882
17. Bellemare DR, Shaner L, Morano KA, Beaudoin J, Langlois R, Labbe S (2002) Ctr6, a vacuolar membrane copper transporter in Schizosaccharomyces pombe. J Biol Chem 277:46676-46686
18. Kuo YM, Zhou B, Cosco D, Gitschier J (2001) The copper transporter CTR1 provides an essential function in mammalian embryonic development. Proc Natl Acad Sci USA 98:6836-6841
19. Lee J, Prohaska JR, Thiele DJ (2001) Essential role for mammalian copper transporter Ctrl in copper homeostasis and embryonic development. Proc Natl Acad Sci USA 98:6842-6847
20. Lee J, Petris MJ, Thiele DJ (2002) Characterization of mouse embryonic cells deficient in the Ctr1 high-affinity copper transporter. Identification of a Ctr1-independent copper transport system. J Biol Chem 277:40253-40259
21. Huffman DL, O'Halloran TV (2001) Function, structure, and mechanism of intracellular copper trafficking proteins. Annu Rev Biochem 70:677-701
22. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, Andrews NC (1998) Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci USA 95:1148-1153
23. Fleming MD, Trenor CC III, Su MA, Foernzler D, Beier DR, Dietrich WF, Andrews NC (1997) Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16:383-386
24. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388:482-488
25. Petris MJ, Smith K, Lee J, Thiele DJ (2003) Copper-stimulated endocytosis and degradation of the human copper transporter, hCtr1. J Biol Chem 278:9639-9646
26. Ooi CE, Rabinowich E, Dancis A, Bonifacino JS, Klausner RD (1996) Copper-dependent degradation of the Saccharomyces cerevisiae plasma membrane copper transporter Ctrlp in the apparent absence of endocytosis. EMBO J 15:3515-3523
27. Sullivan AL, Grasso JA, Weintraub LR (1976) Micropinocytosis of transferrin by developing red cells: an electron-microscopic study utilizing ferritin-conjugated transferrin and ferritin-conjugated antibodies to transferrin. Blood 47:133-143