Impairment of fetal endothelium-dependent relaxation in a rat model of preeclampsia by chronic nitric oxide synthase inhibition

Journal of the Society for Gynecologic Investigation

Volumn 11, Issue 2, 2004, Pages 82-88

  Martínez Orgado, José ^a   González, Rita ^b   Alonso, María J ^b   Salaices, Mercedes ^b  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^b NONE

Author keywords

Endothelium; Fetus; Hyperpolarization; Nitric oxide; Preeclampsia

Indexed keywords

ACETYLCHOLINE; CAPSAICIN; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; POTASSIUM CHLORIDE; PROSTAGLANDIN F2 ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM; ENZYME INHIBITION; FEMALE; FETUS; FETUS MEMBRANE; NONHUMAN; PREECLAMPSIA; PRIORITY JOURNAL; RAT;

ACETYLCHOLINE; ANIMALS; ARGININE; DINOPROST; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; FETUS; MUSCLE CONTRACTION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; NITROPRUSSIDE; OMEGA-N-METHYLARGININE; POTASSIUM CHLORIDE; PRE-ECLAMPSIA; PREGNANCY; RATS; RATS, WISTAR; VASODILATION;

EID: 1242317015     PISSN: 10715576     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsgi.2003.08.003     Document Type: Article

References (32)

1. Naeye R.L., Friedman E.A. Causes of perinatal death associated with gestational hypertension and proteinuria. Am J Obstet Gynecol. 133:1979;8-10.
2. Brazy J.E., Grimm J.K., Little V.A. Neonatal manifestations of severe maternal hypertension ocurring before the thirty-sixth week of pregnancy. J Pediatr. 100:1982;265-271.
3. Hartikainen A.L., Aliharmi R.H., Rantakallio P.T. A cohort study of epidemiological associations and outcomes of pregnancies with hypertensive disorders. Hypertens Pregn. 17:1998;31-41.
4. Martínez-Orgado J., Guardia-Nieto L., Cueto-Calvo E., Lozano-Maneiro L., Martínez M.C., Torres-Martí J. Influencia del tipo de estado hipertensivo del embarazo en la aparición de complicaciones neonatales. Rev Esp Pediatr. 54:1998;379-385.
5. Jacobson S.L., Imhof R., Manning R., Mannion V., Little D., Rey E. The value of Doppler assessment of the uteroplacental circulation in predicting preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol. 162:1990;110-114.
6. Jouppila P., Kirkinen P. Blood velocity waveforms of the fetal aorta in normal and hypertensive pregnancies. Obstet Gynecol. 67:1986;856-860.
7. Bush K.D., O'Brien J.M., Barton J.R. The utility of umbilical artery Doppler investigation in women with the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. Am J Obstet Gynecol. 184:2001;1087-1089.
8. Martikainen A.M., Heinonen K.M., Saarikoski S.V. The effect of the hypertension in pregnancy on fetal and neonatal condition. Int J Gynaecol Obstet. 30:1989;213-220.
9. Zeeman G.G., Dekker G.A. Pathogenesis of preeclampsia A hypothesis . Clin Obstet Gynecol. 35:1992;317-337.
10. Roberts J.M., Redman C.W.G. Preeclampsia More than pregnancy-induced hypertension . Lancet. 341:1993;1447-1451.
11. Friedman S.A., Schiff E., Emeis J.J., Dekker G.A., Sibai B.M. Biochemical corroboration of endothelial involvement in severe preeclampsia. Am J Obstet Gynecol. 172:1995;202-203.
12. Davidge S.T., Signorella A.P., Hubel C.A., Lykins D.L., Roberts J.M. Distinct factors in plasma of preeclamptic women increase endothelial nitric oxide and prostacyclin. Hypertension. 28:1996;758-764.
13. Davidge S.T., Signorella A.P., Lykins D.L., Gilmour C.H., Roberts J.M. Evidence of endothelial activation and endothelial activators in cord blood of infants of preeclamptic women. Am J Obstet Gynecol. 175:1996;1301-1306.
14. McCarthy A.L., Woolfson R.G., Raju S.K., Poston L. Abnormal endothelial cell function of resistance arteries from women with preeclampsia. Am J Obstet Gynecol. 168:1993;1323-1330.
15. Rutherford R.A.D., McCarthy A., Sullivan M.H.F., Elder M.G., Polak J.M., Wharton J. Nitric oxide synthase in human placenta and umbilical cord from normal, intrauterine growth-retarded and pre-eclamptic pregnancies. Br J Obstet Gynaecol. 116:1995;3099-3109.
16. 2+ regulation and NO production in human fetal venous endothelial cells. FASEB J. 16:2002;721-723.
17. Knock G.A., Poston L. Bradykinin-mediated relaxation in isolated maternal resistance arteries in normal pregnancy and preeclampsia. Am J Obstet Gynecol. 175:1996;1668-1674.
18. Pinto A., Sorrentino R., Sorrentino P., Guerritore T., Miranda L., Biondi A. Endothelial-derived relaxing factor released by endothelial cells of human umbilical vessel and its impairment in pregnancy-induced hypertension. Am J Obstet Gynecol. 164:1991;507-513.
19. Arias F. Accuracy of the middle-cerebral-to-umbilical-artery resistance index ratio in the prediction of neonatal outcome in patients at high risk for fetal and neonatal complications. Am J Obstet Gynecol. 171:1994;1541-1545.
20. Molnár M., Sütö T., Tóth T., Hertelendy F. Prolonged blockade of nitric oxide synthase in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation. Am J Obstet Gynecol. 170:1994;1458-1466.
21. ω-L-arginine methylester (L-NAME) impairs endothelium-dependent relaxation in gravid but not in non-gravid rats. J Soc Gynecol Investig. 2:2003;74-81.
22. Martínez-Orgado J., González R., Alonso M.J., Marín J. Nitric oxide-dependent and -independent mechanisms in the relaxation elicited by acetylcholine in fetal rat aorta. Life Sci. 64:1999;269-277.
23. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide Physiology, pathophysiology, and pharmacology . Pharmacol Rev. 43:1991;109-142.
24. Hishikawa K., Kakaki T., Suzuki H., Kato R., Saruta T. Role of L-arginine Nitric oxide pathway in hypertension . J Hypertens. 11:1993;639-645.
25. Marín J., Rodríguez-Martínez M.A. Role of vascular nitric oxide in physiological and pathological conditions. Pharmacol Ther. 75:1997;111-134.
26. ω-nitro-L-arginine methyl ester are not solely mediated by inhibition of endothelial nitric oxide synthesis in the rat mesenteric artery. J Cardiovasc Pharmacol. 33:1999;554-566.
27. Corriu C., Feletou M., Puybasset L., Bea M.L., Berdeaux A., Vanhoutte P.M. Endothelium-dependent hyperpolarization in isolated arteries taken from animals treated with NO-synthase inhibitors. J Cardiovasc Pharmacol. 32:1998;944-950.
28. Bauersachs J., Popp R., Hecker M., Sauer E., Fleming I., Busse R. Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation. 94:1996;3341-3347.
29. Maeso R., Navarro-Cid J., Rodrigo E., Ruilope L.M., Cachofeiro V., Lahera V. Effects of antihypertensive therapy on factors mediating endothelium-dependent relaxation in rats treated chronically with L-NAME. J Hypertens. 17:1999;221-227.
30. G-nitro-L-arginine methyl ester-induced hypertension during pregnancy. Hypertension. 29:1997;248-253.
31. Voelker C.A., Miller M.J., Zhang X.J., Eloby-Childress S., Clark D.A., Pierce M.J. Perinatal nitric oxide synthase inhibition retards neonatal growth by inducing hypertrophic pyloric stenosis in rats. Pediatr Res. 35:1995;768-774.
32. Pearce W.J., Longo L.D. Developmental aspects of endothelial function. Semin Perinatol. 15:1991;40-48.