Plant proteome analysis

Proteomics

Volumn 4, Issue 2, 2004, Pages 285-298

  Cánovas, Francisco M ^a   Dumas Gaudot, Eliane ^b   Recorbet, Ghislaine ^b   Jorrin, Jesus ^c   Mock, Hans Peter ^d   Rossignol, Michel ^e  

^a UNIVERSITY OF MÁLAGA   (Spain)

^b UNIVERSITÉ DE BOURGOGNE   (France)

^c UNIVERSITY OF CÓRDOBA   (Spain)

^d LEIBNIZ INSTITUTE OF PLANT GENETICS AND CROP PLANT RESEARCH IPK   (Germany)

^e CEMAGREF   (France)

Author keywords

Plant proteome; Review; Symbiosis; Tree physiology; Two dimensional gel electrophoresis

Indexed keywords

PROTEOME;

CELL ORGANELLE; CELLULAR DISTRIBUTION; CHLOROPLAST; CONFERENCE PAPER; CROP PRODUCTION; ECOLOGY; ECONOMIC ASPECT; ECTOMYCORRHIZA; ENDOMYCORRHIZA; GERMINATION; MASS SPECTROMETRY; MITOCHONDRION; NITROGEN FIXATION; NUCLEOTIDE SEQUENCE; PLANT; PLANT MICROORGANISM INTERACTION; PLANT PATHOGEN INTERACTION; PLANT PROTEOMICS; PLASTID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; SYMBIOSIS; TREE; WOODY STEM;

ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GERMINATION; MASS SPECTROMETRY; PLANT PROTEINS; PLANTS; PROTEOME; SYMBIOSIS;

EID: 1242316956     PISSN: 16159853     EISSN: None     Source Type: Journal    
DOI: 10.1002/pmic.200300602     Document Type: Conference Paper

References (176)

1. Thiellement, H., Bahrman, N., Damerval, C., Plomion, C. et al., Electrophoresis 1999, 20, 2013-2026.
2. Zivy, M., de Vienne, D., Plant Mol. Biol. 2000, 44, 575-580.
3. van Wijk, K. J., Plant Physiol. 2001, 126, 501-508.
4. Rossignol, M., Curr. Opin. Biotechnol. 2001, 12, 131-134.
5. Porubleva, L., Vander Velden, K., Kothari, S., Oliver, D. J. et al., Electrophoresis 2001, 22, 1724-1738.
6. Gallardo, K., Job, C., Groot, S. P. C., Puype, M. et al., Plant Physiol. 2001, 126, 835-848.
7. Gallardo, K., Job, C., Groot, S. P. C., Puype, M. et al., Plant Physiol. 2002, 129, 823-837.
8. Finnie, C., Melchior, S., Roepstorff, P., Svensson, B., Plant Physiol. 2002, 129, 1308-1319.
9. Maltman, D. J., Simon, W. J., Wheeler, C. H., Dunn, M. J. et al., Electrophoresis 2002, 23, 626-639.
10. Goff, S. A., Ricke, D., Lan, T. H., Presting, G. et al., Science 2002, 296, 92-100.
11. Koller, A., Washburn, M. P., Lange, B. M., Andon, N. L. et al., Proc. Natl. Acad. Sci. USA 2002, 99, 11969-11974.
12. Woo, S. H., Fukuda, M., Islam, N., Takaoka, M. et al., Electrophoresis 2002, 23, 647-654.
13. Hajduch, M., Rakwal, R., Agrawal, G. K., Yonekura, M., et al., Electrophoresis 2001, 22, 2824-2831.
14. Santoni, V., Bellini, C., Caboche, M., Planta 1994, 192, 557-566.
15. Herbik, A., Giritch, A., Horstmann, C., Becker, R. et al., Plant Physiol. 1996, 111, 533-540.
16. Moseley, J. L., Allinger, T., Herzog, S., Hoerth, P. et al., EMBO J 2002, 21, 6709-6720.
17. Santoni, V., Delarue, M., Caboche, M., Bellini, C., Planta 1997, 202, 62-69.
18. Faure, J. D., Vittorioso, P., Santoni, V., Fraisier, V. et al., Development 1998, 125, 909-918.
19. Kasten, B., Buck, F., Nuske, J., Reski, R., Planta 1997, 201, 261-272.
20. Tacchini, P., Fink, A., Thiellement, H., Greppin, H., Physiol. Plant. 1995, 93, 312-316.
21. Damerval, C., De Vienne, D., Heredity 1993, 70, 38-51.
22. Damerval, C., Le Guilloux, M., Mol. Gen. Genet. 1998, 257, 354-361.
23. Thiellement, H. P., C. Zivy, M., Pennington, M. J. (Ed.), in: Proteomics, BIOS Scientific Publishers, Oxford 2001, pp. 289-309.
24. Burstin, J., Devienne, D., Dubreuil, P., Damerval, C., Theor. Appl. Genet. 1994, 89, 943-950.
25. Riccardi, F., Gazeau, P., de Vienne, D., Zivy, M., Plant Physiol. 1998, 117, 1253-1263.
26. Kristoffersen, H. E., Flengsrud, R., Electrophoresis 2000, 21, 3693-3700.
27. Ostergaard, O., Melchior, S., Roepstorff, P., Svensson, B., Proteomics 2002, 2, 733-739.
28. Skylas, D. J., Copeland, L., Rathmell, W. G., Wrigley, C. W., Proteomics 2001, 1, 1542-1546.
29. De Vienne, D. B. J., Gerber, S., Leonardi, A., Le Guilloux, M., et al., Heredity 1996, 76, 166-176.
30. Touzet, P., Morin, C., Damerval, C., Leguilloux, M. et al., Electrophoresis 1995, 16, 1289-1294.
31. Plomion, C. C., P. Bahrmann, N., Frigerio, J. M., Silvae Genetica 1997, 46, 161-165.
32. Damerval, C., Maurice, A., Josse, J. M., Devienne, D., Genetics 1994, 137, 289-301.
33. Jansen, R. C., Nap, J. P., Trends Genet. 2001, 17, 388-391.
34. Consoli, L., Lefevre, A., Zivy, M., de Vienne, D. et al., Plant Mol. Biol. 2002, 48, 575-581.
35. Girke, T., Todd, J., Ruuska, S., White, J. et al., Plant Physiol. 2000, 124, 1570-1581.
36. Seki, M., Narusaka, M., Ishida, J., Nanjo, T. et al., Plant J. 2002, 31, 279-292.
37. Robertson, D., Mitchell, G. P., Gilroy, J. S., Gerrish, C. et al., J. Biol. Chem. 1997, 272, 15841-15848.
38. Santoni, V., Rouquie, D., Doumas, P., Mansion, M. et al., Plant J. 1998, 16, 633-641.
39. Prime, T. A., Sherrier, D. J., Mahon, P., Packman, L. C. et al., Electrophoresis 2000, 21, 3488-3499.
40. Santoni, V., Rabilloud, T., Doumas, P., Rouquie, D. et al., Electrophoresis 1999, 20, 705-711.
41. Peltier, J. B., Friso, G., Kalume, D. E., Roepstorff, P. et al., Plant Cell 2000, 12, 319-341.
42. Schubert, M., Petersson, U. A., Haas, B. J., Funk, C. et al., J. Biol. Chem. 2002, 277, 8354-8365.
43. Hippler, M., Klein, J., Fink, A., Allinger, T. et al., Plant J. 2001, 28, 595-606.
44. Gomez, S. M., Nishio, J. N., Faull, K. F., Whitelegge, J. P., Mol. Cell. Proteomics 2002, 1, 46-59.
45. Seigneurin-Berny, D., Rolland, N., Garin, J., Joyard, J., Plant J. 1999, 19, 217-228.
46. Ferro, M., Seigneurin-Berny, D., Rolland, N., Chapel, A. et al., Electrophoresis 2000, 21, 3517-3526.
47. Ferro, M., Salvi, D., Riviere-Rolland, H., Vermat, T. et al., Proc. Natl. Acad. Sci. USA 2002, 99, 11487-11492.
48. Yamaguchi, K., von Knoblauch, K., Subramanian, A. R., J. Biol. Chem. 2000, 275, 28455-28465.
49. Yamaguchi, K., Subramanian, A. R., J. Biol. Chem. 2000, 275, 28466-28482.
50. Peltier, J. B., Ytterberg, J., Liberles, D. A., Roepstorff, P. et al., J. Biol. Chem. 2001, 276, 16318-16327.
51. Kruft, V., Eubel, H., Jansch, L., Werhahn, W. et al., Plant Physiol. 2001, 127, 1694-1710.
52. Millar, A. H., Sweetlove, L. J., Giege, P., Leaver, C. J., Plant Physiol. 2001, 127, 1711-1727.
53. Werhahn, W., Braun, H. P., Electrophoresis 2002, 23, 640-646.
54. Millar, A. H., Heazlewood, J. L., Plant Physiol. 2003, 131, 443-453.
55. Miras, S., Salvi, D., Ferro, M., Grunwald, D. et al., J. Biol. Chem. 2002, 277, 47770-47778.
56. Whetten, R., Sun, Y. H., Zhang, Y., Sederoff, R., Plant Mol. Biol. 2001, 47, 275-291.
57. Groome, M. C. A. S., Giffort, D. J., Physiol. Plant. 1991, 83, 99-106.
58. Ekramoddoullah, A. K. M., Tan, Y., Can. J. Plant Pathol. Rev. Can. Phytopathol. 1998, 20, 308-318.
59. Costa, P., Bahrman, N., Frigerio, J. M., Kremer, A. et al., Plant Mol. Biol. 1998, 38, 587-596.
60. Avila, C., Garcia-Gutierrez, A., Crespillo, R., Canovas, F. M., Plant Physiol. Biochem. 1998, 36, 857-863.
61. Bahrman, N., Petit, R. J., J. Mol. Evol. 1995, 41, 231-237.
62. Plomion, C., Bahrman, N., Durel, C. E., Omalley, D. M., Heredity 1995, 74, 661-668.
63. Saez, C. A., Munoz-Chapuli, R., Plomion, C., Frigerio, J. M. et al., FEBS Lett. 2000, 477, 237-243.
64. Bradshaw, H. D., Ceulemans, R., Davis, J., Stettler, R., J. Plant Growth Regul. 2000, 19, 306-313.
65. Lev-Yadun, S., Sederoff, R., J. Plant Growth Regul. 2000, 19, 290-305.
66. Sterky, F., Regan, S., Karlsson, J., Hertzberg, M. et al., Proc. Natl. Acad. Sci. USA 1998, 95, 13330-13335.
67. Allona, I., Quinn, M., Shoop, E., Swope, K. et al., Proc. Natl. Acad. Sci. USA 1998, 95, 9693-9698.
68. Cantón, F. R., Garcia, V., Barré, A., Frigério, J.-M. et al., in: Ritter, E., Espinel, G., Barrade, Y. (Eds.), Sustainable Forestry, Woods products and Biotechnology, DFA, Vitoria (in press).
69. Hertzberg, M., Aspeborg, H., Schrader, J., Andersson, A. et al., Proc. Natl. Acad. Sci. USA 2001, 98, 14732-14737.
70. Stasolla, C., van Zyl, L., Egertsdotter, U., Craig, D. et al., Plant Physiol. 2003, 131, 49-60.
71. van Zyl, L., von Arnold, S., Bozhkov, P., Chen, Y. Z. et al., Compar. Funct. Genom. 2002, 3, 306-318.
72. Heath, L. S., Ramakrishnan, N., Sederoff, R. R., Whetten, R. W. et al., Compar. Funct. Genom. 2002, 3, 226-243.
73. Costa, P., Pionneau, C., Bauw, G., Dubos, C. et al., Electrophoresis 1999, 20, 1098-1108.
74. Plomion, C., Pionneau, C., Brach, J., Costa, P. et al., Plant Physiol. 2000, 123, 959-969.
75. Vander Mijnsbrugge, K., Meyermans, H., Van Montagu, M., Bauw, G. et al., Planta 2000, 210, 589-598.
76. Chaffey, N., Cholewa, E., Regan, S., Sundberg, B., Physiol. Plant. 2002, 114, 594-600.
77. Hensel, M., Holden, D. W., Microbiol. 1996, 142, 1049-1058.
78. Konishi, H., Ishiguro, K., Komatsu, S., Proteomics 2001, 1, 1162-1171.
79. Rep, M., Dekker, H. L., Vossen, J. H., de Boer, A. D. et al., Plant Physiol. 2002, 130, 904-17.
80. Rakwal, R., Komatsu, S., Electrophoresis 2000, 21, 2492-2500.
81. Lecourieux-Ouaked, F., Pugin, A., Lebrun-Garcia, A., Mol. Plant Microbe Interact. 2000, 13, 821-829.
82. Peck, S. C., Nuhse, T. S., Hess, D., Iglesias, A. et al., Plant Cell 2001, 13, 1467-1475.
83. Mehta, A., Rosato, Y. B., Proteomics 2001, 1, 1111-1118.
84. Smolka, M. B., Martins, D., Winck, F. V., Santoro, C. E. et al., Proteomics 2003, 3, 224-237.
85. Cyranoski, D., Nature 2001, 409, 272.
86. Journet, E. P., Carreau, V., Gouzy, J., Thoquet, P. et al., OCL-Oleagineux Corps Gras Lipides 2001, 8, 478-484.
87. Frugoli, J., Harris, J., The Plant Cell 2001, 13, 458-462.
88. Oldroyd, G. E. D., Geurts, R., Trends Plant Sci. 2001, 6, 552-553.
89. Barker, D. G., Bianchi, S., Blondon, F., Dattée, Y. et al., Plant Molecular Biology Reporter 1990, 8, 40-49.
90. Handberg, K., Stougaard, J., Plant J. 1992, 2, 487-496.
91. Kawasaki, S., Murakami, Y., J. Plant Res. 2000, 113, 497-506.
92. Bell, C., Dixon, R. A., Farmer, A. D., Flores, R. et al., Nucieic Acids Res. 2001, 29, 114-117.
93. Quackenbush, J., Liang, F., Holt, I., Pertea, G. et al., Nucleic Acids Res. 2000, 8, 141-145.
94. Journet, E. P., van Tuinen, D., Gouzy, J., Crespeau, H. et al., Nucleic Acids Res. 2002, 30, 5579-5592.
95. Penmetsa, R. V., Cook, R. D., Plant Physiol. 2000, 123, 1387-1397.
96. Sagan, M., Morandi, D., Tarenghi, E., Duc, G., Plant Sci. 1995, 111, 63-71.
97. Borisov, A. Y., Jakobi, L., Lebsky, V., Morzhina, E. V. et al., Pisum Genet. 1999, 3, 40-44.
98. Catoira, R., Galera, C., de Billy, F., Penmetsa, R. V. et al., Plant Cell 2000, 12, 1647-1665.
99. Walker, S. A., Viprey, V., Downie, J. A., Proc. Natl. Acad. Sci. USA 2000, 97, 13413-13418.
100. Marsh, J. F., Schultze, M., New Phytol. 2001, 150, 525-532.
101. Van Rhijn, P., Vanderleyden, J., Microbiol. Rev. 1995, 59, 124-142.
102. Lhuissier, F. G. P., DeRuijter, N. C. A., Sieberer, B. J., Esseling, J. J. et al., Ann. Bot. 2001, 87, 289-302.
103. Cook, D. R., Curr. Opin. Plant Biol. 1999, 2, 301-304.
104. Colebatch, G., Trevaskis, B., Udvardi, M., New Phytol. 2002, 153, 37-42.
105. Stougaard, J., Curr. Opin. Plant Biol. 2001, 4, 328-35.
106. Govers, F., Gloudemans, T., Moerman, M., van Kammen, A. et al., EMBO J. 1985, 4, 861-867.
107. Natera, S. H. A., Guerreiro, N., Djordjevic, N. A., Mol. Plant Microbe Interact. 2000, 13, 995-1009.
108. Morris, A. C., Djordjevic, M. A., Electrophoresis 2001, 22, 586-98.
109. Mathesius, U., Keijzers, G., Natera, S. H. A., Weinman, J. J. et al., Proteomics 2001, 1, 1424-1440.
110. Winzer, T., Bairl, A., Linder, M., Linder, D. et al., Mol. Plant Microbe Interact. 1999, 12, 218-226.
111. Panter, S., Thomson, R., deBruxelles, G., Laver, D. et al., Mol. Plant Microbe Interact. 2000, 13, 325-333.
112. Saalbach, G., Erik, P., Wienkoop, S., Proteomics 2002, 2, 325-337.
113. Hammad, Y., Marechal, J., Cournoyer, B., Normand, P. et al., Can. J. Bot. 2001, 47, 541-547.
114. Hilbert, J. L., Costa, G., Martin, F., Plant Physiol. 1991, 97, 977-984.
115. Simoneau, P., Viemont, J. D., Moreau, J. C., Strulu, D. J., New Phytol. 1993, 124, 495-504.
116. Burgess, T., Laurent, P., Dell, B., Malajczuk, N. et al., Planta 1995, 195, 408-417.
117. Burgess, T., Dell, B., Can. J. Bot. 1996, 74, 553-560.
118. Laurent, P., Voiblet, C., Tagu, D., de Carvalho, D. et al., Mol. Plant Microbe Interact. 1999, 12, 862-871.
119. Niini, S. S., Tarkka, M. T., Raudaskoski, M., Physiol. Plant. 1996, 96, 186-192.
120. Timonen, S., Finlay, R., Söderström, B., Raudaskoski, M., The New Phytologist 1993, 124, 83-92.
121. Timonen, S., Söderström, B., Raudaskoski, M., Mycorrhiza 1996, 6, 423-429.
122. Tarkka, M. T., Nyman, T. A., Kalkinen, N., Raudaskoski, M., Eur. J. Biochem. 2000, 267, 1-8.
123. Tarkka, M. T., Nyman, T. A., Kalkinen, N., Raudaskoski, M., Eur. J. Biochem. 2001, 268, 86-92.
124. Vallorani, L., Bernardini, F., Sacconi, C., Pierleoni, R. et al., Electrophoresis 2000, 21, 3710-3716.
125. Smith, S. E., Read, D. J., in: Smith, S. E., Read, D. J. (Eds.), Mycorrhizal Symbiosis, Academic Press, New York 1997.
126. Garcia-Garrido, J. M., Toro, N., Ocampo, J. A., Mycorrhiza 1993, 2, 175-177.
127. Dumas-Gaudot, E., Guillaume, P., Tahiri-Alaoui, A., Gianinazzi-Pearson, V. et al., Mycorrhiza 1994, 4, 215-221.
128. Simoneau, P., Louisy-Lois, N., Plenchette, C., Strullu, D. G., AEM 1994, 60, 1810-1813.
129. Samra, A., Dumas-Gaudot, E., Gianinazzi, S., New Phytol. 1997, 135, 711-722.
130. Dassi, B., Samra, A., Dumas-Gaudot, E., Gianinazzi, S., Symbiosis 1999, 26, 65-77.
131. Benabdellah, K., Azcon-Aguilar, C., Ferrol, N., New Phytol. 1998, 140, 135-143.
132. Benabdellah, K., AzconAguilar, C., Ferrol, N., J. Exp. Bot. 2000, 51, 747-754.
133. Fester, T., Kiess, M., Strack, D., Mycorrhiza 2002.
134. Dumas-Gaudot, E., Bestel-Corre, G., Gianinazzi, S., in: Pandalai, S. G. (Ed.), Recent Research Developments in Plant Biology, Research Signpost: Trivandrum, India 2001, pp. 95-104.
135. Bestel-Corre, G., Dumas-Gaudot, E., Poinsot, V., Dieu, M. et al., Electrophoresis 2002, 23, 122-137.
136. Gianinazzi-Pearson, V., Dénarié, J., Trends Plant Sci. 1997, 2, 371-372.
137. Harrison, M. J., Annu. Rev. Plant Physiol. Plant Mol. Biol. 1999, 50, 361-389.
138. Frühling, M., Roussel, H., Gianinazzi-Pearson, V., Puhler, A. et al., Mol. Plant Microbe Interact. 1997, 10, 124-131.
139. Balestrini, R., Perotto, S., Gasverde, E., Dahiya, P. et al., Mol. Plant Microbe Interact. 1999, 12, 785-791.
140. Bonfante, P., Genre, A., Faccio, A., Martini, I. et al., Mol. Plant Microbe Interact. 2000, 13, 1109-1120.
141. Journet, E. P., ElGachtouli, N., Vernoud, V., deBilly, F. et al., Mol. Plant Microbe Interact. 2001, 14, 737-748.
142. Werner, D., Barea, J. M., Brewin, N. J., Cooper, J. E. et al., Symbiosis 2002, 32, 83-104.
143. Bestel-Corre, G., Dumas-Gaudot, E., Gianinazzi, S., Proteomics 2003, 3, in press.
144. Samra, A., Dumas-Gaudot, E., Gianinazzi-Pearson, V., Gianinazzi, S., Agronomie 1996, 16, 709-719.
145. Bestel-Corre, G., Dumas-Gaudot, E., St-Arnaud, M., Fontaine, B. et al., Mol Plant Microbe Interact. 2003, in press.
146. Boisson-Dernier, A., Chabaud, M., Garcia, F., Becard, G. et al., Mol. Plant Microbe Interact. 2001, 14, 695-700.
147. Bestel-Corre, G., Dumas-Gaudot, E., Hartmann, A., Gianinazzi, S., AEM 2003, in press.
148. Bestel-Corre, G., Dumas-Gaudot, E., Gianinazzi, S., Agronomie 2003, in press.
149. Repetto, O., Bestel-Corre, G., Dumas-Gaudot, E., Berta, G. et al., New Phytol. 2002, 555-567.
150. Molloy, M. P., Anal. Biochem. 2000, 280, 1-10.
151. Rabilloud, T., Electrophoresis 1998, 19, 758-760.
152. Santoni, V., Kieffer, S., Desclaux, D., Masson, F. et al., Electrophoresis 2000, 21, 3329-3344.
153. Santoni, V., Molloy, M., Rabilloud, T., Electrophoresis 2000, 21, 1054-1070.
154. Wienkoop, S., Saalbach, G., Plant Physiol. 2003, 131, 1080-90.
155. Holtorf, H., Guitton, M.-C., Reski, R., Naturwissenschaften 2002, 89, 235-249.
156. Watson, B. S., Asirvatham, V. S., Wang, L., Sumner, L. W., Plant Physiol. 2003, 131, 1104-1123.
157. Tyers, M., Mann, M., Nature 2003, 422, 193-197.
158. Aebersold, R., Mann, M., Nature 2003, 422, 198-207.
159. Phizicky, E., Bastiaens, P. I. H., Zhu, H., Snyder, M. et al., Nature 2003, 422, 208-215.
160. Giavalisco, P., Nordhoff, E., Lehrach, H., Gobom, J. et al., Electrophoresis 2003, 24, 207-216.
161. Herbert, B., Righetti, P. G., Electrophoresis 2000, 21, 3039-3648.
162. Wildgruber, R., Harder, A., Obermaier, C., Boguth, G. et al., Electrophoresis 2000, 21, 2610-2616.
163. Gorg, A., Boguth, G., Kopf, A., Reil, G. et al., Proteomics 2002, 2, 1652-1657.
164. Hoving, S., Gerrits, B., Voshol, H., Müller, D. et al., Proteomics 2002, 2, 127-134.
165. Patton, W. F., J. Chromatogr. B 2002, 771, 3-31.
166. Tonge, R., Shaw, J., Middleton, B., Rowlinson, R. et al., Proteomics 2001, 1, 377-396.
167. Alban, A., David, S. O., Bjorkesten, L., Andersson, C. et al., Proteomics 2003, 3, 36-44.
168. Oda, Y., Huang, K., Cross, F. R., Cowburn, D. et al., Proc. Natl. Acad. Sci. USA 1999, 96, 6591-6596.
169. Butt, A., Davison, M. D., Smith, G. J., Young, J. A. et al., Proteomics 2001, 1, 42-53.
170. Gygi, S. P., Rist, B., Aebersold, R., Curr. Opin. Biotechnol. 2000, 11, 396-401.
171. Ficarro, S. B., McCleland, M. L., Stukenberg, P. T., Burke, D. J. et al., Nat. Biotechnol. 2002, 20, 301-305.
172. Link, A. J., Eng, J., Schieltz, D. M., Carmack, E. et al., Nat. Biotechnol. 1999, 17, 676-682.
173. Islam, N., Tsujimoto, H., Hirano, H., Proteomics 2003, 3, 307-316.
174. Fields, S., Song, O., Nature 1989, 340, 235-246.
175. Gavin, A. C., Bosche, M., Krause, R., Grandi, P. et al., Nature 2002, 415, 141-147.
176. Forler, D., Kocher, T., Rode, M., Gentzel, M. et al., Nat. Biotechnol. 2003, 21, 89-92.