The Human Pathogen Leishmania donovani Secretes a Histidine Acid Phosphatase Activity that is Resistant to Proteolytic Degradation

Journal of Eukaryotic Microbiology

Volumn 51, Issue 1, 2004, Pages 108-112

  Joshi, Manju B ^a   Mallinson, David J ^a,b   Dwyer, Dennis M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Glycoprotein; Hemoflagellate; Protease resistance; Protozoan parasite; Sandfly vector; Secretory enzyme

Indexed keywords

13 KDA PHOSPHOAMIDASE; HYDROLASE; PROTEINASE;

ENZYME ACTIVITY; LEISHMANIASIS; MICROBIOLOGY;

ANIMAL; ARTICLE; COMPARATIVE STUDY; ENZYME SPECIFICITY; ENZYMOLOGY; HUMAN; ISOLATION AND PURIFICATION; KINETICS; LEISHMANIA DONOVANI; METABOLISM; PATHOGENICITY;

ANIMALS; ENDOPEPTIDASES; HUMANS; HYDROLASES; KINETICS; LEISHMANIA DONOVANI; SUBSTRATE SPECIFICITY;

ANIMALIA; LEISHMANIA DONOVANI; PROTOZOA;

EID: 1242299537     PISSN: 10665234     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1550-7408.2004.tb00171.x     Document Type: Article

References (34)

1. Bates, P. A. & Dwyer, D. M. 1987. Biosynthesis and secretion of acid phosphatase by Leishmania donovani promastigotes. Mol. Biochem. Parasitol., 26:289-296.
2. Bates, P. A., Gottlieb, M. & Dwyer, D. M. 1988. Leishmania donovani: identification of glycoproteins released by promastigotes during growth in vitro. Exp. Parasitol., 67:199-209.
3. Bates, P. A., Hermes, I. & Dwyer, D. M. 1989. Leishmania donovani: immunochemical localization and secretory mechanism of soluble acid phosphatase. Exp. Parasitol., 68:335-346.
4. Bates, P. A., Hermes, I. & Dwyer, D. M. 1990. Golgi-mediated post-translational processing of secretory acid phosphatase by Leishmania donovani promastigotes. Mol. Biochem. Parasitol., 39:247-255.
5. Bates, P. A., Kurtz, M. K., Gottlieb, M. & Dwyer, D. M. 1987. Leishmania donovani: generation of monospecific antibody reagents to soluble acid phosphatase. Exp. Parasitol., 64:157-164.
6. Borovsky, D. & Schlein, Y. 1987. Trypsin and chymotrypsin-like enzymes of the sandfly Phlebotomus papatasi infected with Leishmania and their possible role in vector competence. Med. Vet. Entomol., 1: 235-242.
7. Das, S., Saha, A. K., Remaley, A. T., Glew, R. H., Dowling, J. N., Kajiyoshi, M. & Gottlieb, M. 1986. Hydrolysis of phosphoproteins and inositol phosphates by cell surface phosphatase of Leishmania donovani. Mol. Biochem. Parasitol., 20:143-153.
8. Dillon, R. J. & Lane, R. P. 1993. Influence of Leishmania infection on blood-meal digestion in the sandflies Phlebotomus papatasi and P. langeroni. Parasitol. Res., 79:492-496.
9. Doyle, P. S. & Dwyer, D. M. 1993. Leishmania: immunochemical comparison of the secretory (extracellular) acid phosphatases from various species. Exp. Parasitol., 77:435-444.
10. Ellis, S. L., Shakarian, A. M. & Dwyer, D. M. 1998, Leishmania: amastigotes synthesize conserved secretory acid phosphatases during human infection. Exp. Parasitol., 89:161-168.
11. Garner, B., Merry, A. H., Royle, L., Harvey, D. J., Rudd, P. M. & Thillet, J. 2001. Structural elucidation of the N-and O-glycans of human apolipoprotein (a): role of O-glycans in conferring protease resistance. J. Biol. Chem., 276:22200-22208.
12. Gottlieb, M. & Dwyer, D. M. 1981. Leishmania donovani: surface membrane acid phosphatase activity of promastigotes. Exp. Parasitol., 52:117-128.
13. Gottlieb, M. & Dwyer, D. M. 1982. Identification and partial characterization of an extracellular acid phosphatase activity of Leishmania donovani promastigotes. Mol. Cell. Biol., 2:76-81.
14. Ilg, T., Stierhof, Y. D., Wiese, M., McConville, M. J. & Overath, P. 1994. Characterization of phosphoglycan-containing secretory products of Leishmania. Parasitology, 108(Suppl.):S63-71.
15. Lippert, D. N., Dwyer, D. M., Li, F. & Olafson, R. W. 1999. Phosphoglycosylation of a secreted acid phosphatase from Leishmania donovani. Glycobiology, 9:627-636.
16. Lovelace, J. K., Dwyer, D. M. & Gottlieb, M. 1986. Purification and characterization of the extracellular acid phosphatase of Leishmania donovani. Mol. Biochem. Parasitol., 20:243-251.
17. Mahmood, F. & Borovsky, D. 1992. Biosynthesis of trypsin-like and chymotrypsin-like enzymes in immature Lutzomyia anthophora (Diptera: Psychodidae). J. Med. Entomol., 29:489-495.
18. Mahmood, F. & Borovsky, D. 1993. Biosynthesis of serine proteases in Lutzomyia anthophora (Diptera: Psychodidae). J. Med. Entomol., 30:683-688.
19. Mallinson, D. J. & Coombs, G. H. 1986. Molecular characterization of the metacyclic forms of Leishmania major. IRCS Med. Sci., 14:557-558.
20. McCarthy-Burke, C., Bates, P. A. & Dwyer, D. M. 1991. Leishmania donovani: use of two different, commercially available, chemically defined media for the continuous in vitro cultivation of promastigotes. Exp. Parasitol., 73:385-387.
21. Mengeling, B. J. & Turco, S. J. 1998. Microbial glycoconjugates. Curr. Opin. Struct. Biol., 8:572-577.
22. North, M. J. 1989. Prevention of unwanted proteolysis. In: Beynon, R. J. & Bond, J. S. (ed.), Proteolytic enzymes: a practical approach. IRL Press, Oxford. p. 105-124.
23. Pratap, J., Rajamohan, G. & Dikshit, K. L. 2000. Characteristics of glycosylaled streptokinase secreted from Pichia pastoris: enhanced resistance of SK to proteolysis by glycosylation. Appl. Microbiol. Biotechnol., 53:469-475.
24. Pupkis, M. F. & Coombs, G. H. 1984. Purification and characterization of proteolytic enzymes of Leishmania mexicana mexicana amastigotes and promastigoies. J. Gen. Microbiol., 130:2375-2383.
25. Ramalho-Ortigão, J. M., Kamhawi, S., Rowton, E. D., Ribeiro, J. M. & Valenzuela, J. G. 2003. Cloning and characterization of trypsin-and chymotrypsin-like proteases from the midgut of the sand fly vector Phlebotomus papatasi. Insect Biochem. Mol. Biol., 33:163-171.
26. Remaley, A. T., Das, S., Campbell, P. I., LaRocca, G. M., Pope, M. T. & Glew, R. H. 1985. Characterization of Leishmania donovani acid phosphalases. J. Biol. Chem., 260:880-886.
27. Rudd, P. M., Joao, H. C., Coghill, E., Fiten, P., Saunders, M. R., Opdenakker, G. & Dwek, R. A. 1994. Glycoforms modify the dynamic stability and functional activity of an enzyme. Biochemistry, 33:17-22.
28. Sacks, D. L. 2001. Leishmania-sand fly interactions controlling species-specific vector competence. Cell. Microbiol., 3:189-196.
29. Sareneva, T., Pirhonen, J., Cantell, K. & Julkunen, I. 1995. N-glycosylation of human interferon-gamma: glycans at Asn-25 are critical for protease resistance. Biochem. J., 308:9-14.
30. Schlein, Y. & Jacobson, R. L. 1998, Resistance of Phlebotomus papatasi to infection with Leishmania donovani is modulated by components of the infective bloodmeal. Parasitology, 117:467-473.
31. Shakarian, A. M. & Dwyer, D. M. 2000. Structurally conserved soluble acid phosphatases are synthesized and released by Leishmania major promastigotes. Exp. Parasitol., 95:79-84.
32. Shakarian, A. M., Ellis, S. L., Mallinson, D. J., Olafson, R. W. & Dwyer, D. M. 1997. Two tandemly arrayed genes encode the (histidine) secretory acid phosphatases of Leishmania donovani. Gene, 196:127-137.
33. Shakarian, A. M., Joshi, M. B., Ghedin, E. & Dwyer, D. M. 2002. Molecular dissection of the functional domains of a unique, tartrate-resistant, surface membrane acid phosphatase in the primitive human pathogen Leishmania donovani. J. Biol. Chem., 277:17994-18001.
34. Shakarian, A. M., Joshi, M. B., Yamage, M., Ellis, S. L., Debrabant, A. & Dwyer, D. M. 2003. Members of a unique histidine acid phosphatase family are conserved amongst a group of primitive eukaryotic human pathogens. Mol. Cell. Biochem., 245:31-41.