Synthesis and in vitro cytotoxicity of 5-substituted 2-cyanoimino-4- imidazodinone and 2-cyanoimino-4-pyrimidinone derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 5, 2004, Pages 1169-1172

  Chern, Jyh Haur ^a   Shia, Kak Shan ^a   Chang, Chung Ming ^a   Lee, Chung Chi ^a   Lee, Yen Chun ^a   Tai, Chia Liang ^a   Lin, Ying Ting ^a   Chang, Chih Shiang ^a   Tseng, Huan Yi ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Anticancer

Indexed keywords

4 PYRIMIDINONE DERIVATIVE; ANTINEOPLASTIC AGENT; HETEROCYCLIC COMPOUND; UNCLASSIFIED DRUG; [1 [6 (4 CHLOROPHENOXY)HEXYL] 5 OXO 4 PHENYL 3 (4 PYRIDYL)TETRAHYDRO 1H 2 IMIDAZOLYLIDEN]AMINOMETHANENITRILE;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY;

EID: 1242294354     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.12.073     Document Type: Article

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26. 3) δ 8.71 (d, 2H, J=6.3 Hz), 7.34 (d, 2H, J=6.3 Hz), 7.19 (d, 2H, J=9.0 Hz), 6.80 (d, 2H, J=9.0 Hz), 4.60 (q, 1H, J=6.9 Hz), 3.93-3.88 (m, 4H), 1.80 (m, 4H), 1.55 (m, 4H), 1.46 (d, 3H, J=7.2 Hz); ESMS 426.1 (M+1), 448.1 (M+23).